add GA and Caffeine info

This commit is contained in:
jorts 2025-08-10 17:30:43 +01:00
parent f0667b3338
commit 1b5460026d
8 changed files with 3102 additions and 2 deletions

View File

@ -96,14 +96,64 @@ However, there is not that much discussion of this online. Here is all I could f
Regulatory note: Aminophylline is an FDA-listed prescription drug, so supplies intended for human or animal treatment normally require a prescribers order or a pharmacy/DEA license; research-grade material from chemical suppliers is labeled *not for human or veterinary use* and should be handled in accordance with local hazardous-chemical regulations. [link](https://www.boundtree.com/pharmaceuticals/rx-pharmaceuticals/aminophylline-25mg-ml-20ml-vial/p/5922-01) Regulatory note: Aminophylline is an FDA-listed prescription drug, so supplies intended for human or animal treatment normally require a prescribers order or a pharmacy/DEA license; research-grade material from chemical suppliers is labeled *not for human or veterinary use* and should be handled in accordance with local hazardous-chemical regulations. [link](https://www.boundtree.com/pharmaceuticals/rx-pharmaceuticals/aminophylline-25mg-ml-20ml-vial/p/5922-01)
#### Glycyrrhetinic acid
#### Transdermal Caffeine Much less discussed than aminophylline.
There is like one study from 2005 which seems to suggest a small reduction in a month without negligible weight loss, and it seems like nobody has tried to replicate it:
- [Paper on 9 treatment + 9 control patients](https://pubmed.ncbi.nlm.nih.gov/15894038/){.source-link}
> Weight (kg), before -> after
>
> * treated: 60.5 ± 0.6 -> 60.2 ± 0.6 kg
> * placebo: 59.2 ± 0.4 -> 59.0 ± 0.4 kg
>
> Circumference at middle of thigh (cm), before --> after:
>
> * treated thigh: 52.7 ± 1.0 --> 52.4 ± 1.0
> * untreated thigh: 52.9 ± 1.4 --> 52.8 ± 1.4
> * placebo thigh: 51.9 ± 1.0 --> 51.8 ± 1.0
> * untreated thigh: 51.1 ± 0.9 --> 51.2 ± 0.9
>
> TLDR: 0.3cm difference after 1 month of applying 80mg 2.5% GA daily. minimal change in weight (~0.3kg)
Other studies seem mostly to be in vitro, eg:
- [in vitro lipolysis study](https://www.sciencedirect.com/science/article/abs/pii/S0006291X12005384){.source-link}
There is even less discussion of GA online/on reddit:
- [Reddit post from u/Lopsided_Bar2863 on r/4tran4 on aminophylline and glycyrrhetinic acid](https://old.reddit.com/r/4tran4/comments/1eq12mv/poons_theres_a_lifesaver_to_reduce_your_ass/){.source-link}
#### Topical Caffeine
Caffeine appears to affect the same PDE pathway as aminophylline, but there are not many studies using just caffeine.
Some examples:
* [study on 7% caffeine for cellulite](https://pubmed.ncbi.nlm.nih.gov/17524126/){.source-link}
> "They were told to apply it in just one leg (thigh and hip) in order to keep the other one as control. The solution was applied twice daily (morning and night), and the dose was 15 mL per leg (thigh)."
>
> "99 completed the protocol"
>
> "A 30-day treatment with this caffeine solution showed statistical significance concerning the reduction of circumference in treated thighs. This reduction was observed in more than 80% of the patients and was of about 2.1 cm in the thicker portion of the thigh and 1.7 cm in the lower portion. The use of 7% caffeine solution was also statistically significant in the reduction of hip circumference in 67.7% of the treated patients."
* [study on 3.5% caffeine for cellulite](https://pubmed.ncbi.nlm.nih.gov/26082579/){.source-link}
> Thigh and upper-arm circumferences decreased by 0.7 cm (1.7%) and 0.8 cm (2.3%), respectively, at week 6. (No control was provided).
* [Study on caffeine + retinol + carnitine + others](https://pmc.ncbi.nlm.nih.gov/articles/PMC3933246/){.source-link}
> Maintain usual diet + twice daily (caffeine + retinol + carnitine + others).
> 12 weeks treatment:
>
> Abdomen: 1.1cm (vs 0.4cm)
> Thighs: -0.8cm (vs 0.3cm)
> Hips: 0.8cm (vs 0.4cm)
Transdermal caffein Transdermal caffein
#### Waist-training #### Waist-training
As another option, if looking particularly to improve WHR or get a more hour-glass figure, could be waist training. This can often reduce appetite while worn. If done correctly this is usually quite safe, thought this does often cause the floating ribs 8-12 to shift inwards, and may cause some organs to move around. As another option, if looking particularly to improve WHR or get a more hour-glass figure, could be waist training. This can often reduce appetite while worn. This usually is done by causing the floating ribs 8-12 to shift inwards, and may cause some organs to move around. People who do it consider it safe but DYOR.
#### Rib reshaping surgery #### Rib reshaping surgery

View File

@ -0,0 +1,375 @@
<meta charset='utf-8'>
<base target='_blank'>
<style>
body{font-family:system-ui,sans-serif;max-width:50rem;margin:2rem auto;line-height:1.6;padding:1rem}
img,iframe{max-width:100%}
.post-content{background:#f9f9f9;padding:1rem;border-radius:5px;margin:1rem 0}
.archive-header{background:#f0f8ff;border:1px solid #e0e0e0;border-radius:5px;padding:0.75rem;margin-bottom:1rem;font-size:0.9rem}
.archive-info{margin-bottom:0.5rem;color:#666}
.archive-source{color:#666}
.archive-header a{color:#007acc;text-decoration:none}
.archive-header a:hover{text-decoration:underline}
@media (prefers-color-scheme: dark) {
.archive-header{background:#1a1a2e;border-color:#333;color:#e0e0e0}
.archive-info, .archive-source{color:#ccc}
.archive-header a{color:#66b3ff}
}
</style>
<div class="archive-header">
<div class="archive-info">
<strong>📄 Archived:</strong> 2025-08-10 15:45:38 UTC
</div>
<div class="archive-source">
<strong>🔗 Source:</strong> <a href="https://old.reddit.com/r/4tran4/comments/1mlcyaf/what_cis_girls_get_done_vs_what_trans_girls_get/">https://old.reddit.com/r/4tran4/comments/1mlcyaf/what_cis_girls_get_done_vs_what_trans_girls_get/</a>
</div>
</div>
<script>
// Archive metadata for cache management
window.archiveData = {
url: 'https://old.reddit.com/r/4tran4/comments/1mlcyaf/what_cis_girls_get_done_vs_what_trans_girls_get/',
archivedAt: "2025-08-10T15:45:38.955828+00:00Z",
timestamp: 1754840738955
};
</script>
<hr>
<h1>What cis girls get done VS what trans girls get done</h1>
<p><strong>r/4tran4</strong> • by u/TheForceOfEvil • 42 points</p>
<div class='post-content'><div class="md"><p>Making your shoulder fat slouchy and destroying your collarbones for WHAT?!</p>
<p>Is it in proportion with your waist, hips and ribcage now?! Cuz if you already have a wide ribcage this will only make it look worse especially if you have a masc ribcage and fem shoulders it will throw off the balance.</p>
<p>I think you can tell when a girl(cis or trans) Centers men and sees things from the male gaze instead of female gaze depending on the surgeries she gets</p>
<p>Ex. Boob job + BBL VS Rhinoplasty + Brow lift</p>
</div></div>
<hr>
<h2>Comments</h2>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/jellybeanzz11</strong> • 15 points
</div>
<div>
<div class="md"><p>the difference is ropefuel...</p>
</div>
</div>
<div style="margin-left: 20px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/TheForceOfEvil</strong> • 18 points
</div>
<div>
<div class="md"><p>It literally looks like she gained 50 pounds it doesnt even look smaller and its so expensive too. Any girl would kill to have these collarbones wtfff</p>
</div>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/WanderingWonders77</strong> • 13 points
</div>
<div>
<div class="md"><p>I'm not really impressed with clavicle reduction tbh. the slouch doesn't seem worth it (it looks even worse from the side tbh)</p>
<p>t. bideltoidhon</p>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/F2Misanthrope</strong> • 7 points
</div>
<div>
<div class="md"><p>would it be possible to get clavical shortening and then the shoulder unslopening</p>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/You-Looked</strong> • 8 points
</div>
<div>
<div class="md"><p>This shit is hopeless</p>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/Impressive_Fish3957</strong> • 3 points
</div>
<div>
<div class="md"><p>trap botox only lasts a few months while surgery is permanent so this isn't a fair comparison. i do agree with you that the first photo looks better though</p>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/zunCannibal</strong> • 4 points
</div>
<div>
<div class="md"><p>collarbones on 2nd pic looked like they were about to escape</p>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/blown-transmission</strong> • 4 points
</div>
<div>
<div class="md"><p>Ugly passoid or slightly clocky elf woman</p>
<p>Choice is yours</p>
</div>
</div>
<div style="margin-left: 20px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/New-Tie-2255</strong> • 1 points
</div>
<div>
<div class="md"><p>ugly passoid</p>
</div>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/notdyingb4ffs</strong> • 4 points
</div>
<div>
<div class="md"><p>clavicle reduction seems like a surgery for stupid or rich ppl atp. like you said its cope because what actually matters is how your WHR and ribcage flow into your shoulders. your body needs to look balanced and itll look disproportionate like a girl that never works out getting a BBL.</p>
<p>trans women are better off getting a BA to offset their larger ribcages while getting better posture. i see so many tgirls complaining about their upper bodies while having awful posture, slouching makes you look a lot wider and looks worse!</p>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/Delicious-Raise-17</strong> • 3 points
</div>
<div>
<div class="md"><p>Trans women are nothing like cis women, unfortunatly</p>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/wistfulfaerie</strong> • 2 points
</div>
<div>
<div class="md"><p>Its over 😞</p>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/summer-years</strong> • 3 points
</div>
<div>
<div class="md"><p>Genuinely ty for reminding me that this cope I've been dreaming about is regarded and that I need to corsetmaxx or smthn</p>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/Jamtlanta</strong> • 1 points
</div>
<div>
<div class="md"><p>If more horizontal shoulders still look feminine, what makes them look masculine? Is it just the breadth? I'm a pooner with sloped shoulders and can't tell if they look better or worse when I try to shrug them up because doing that decreases the shoulder breadth and neck length.</p>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/Intelligent-Tea-2058</strong> • 1 points
</div>
<div>
<div class="md"><blockquote>
<p>Is it in proportion with your waist, hips and ribcage now?! Cuz if you already have a wide ribcage this will only make it look worse especially if you have a masc ribcage and fem shoulders it will throw off the balance.</p>
</blockquote>
<p>I plan to go for complete center surgery for this reason (insurance pending, inb4 denial fight)</p>
<p>I will lyk if it works for the dysphoria and if I'm more uggo after or not</p>
</div>
</div>
<div style="margin-left: 20px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/atillathetwink</strong> • 2 points
</div>
<div>
<div class="md"><p>I don't think I've heard of complete center surgery before, is it something that actually reduces your whole ribcage? I really need something like that but ive only seen it referenced once there's not a lot of information I can find about whether its even possible</p>
</div>
</div>
<div style="margin-left: 40px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/Intelligent-Tea-2058</strong> • 4 points
</div>
<div>
<div class="md"><p>It's a joke, given how people talk about top and bottom surgery... <span class="md-spoiler-text">(I cringe at these new terms thh)</span> why not "center surgery"?? 🥺 my thorax needs fixing 🥺</p>
<p>What I am seeking though is:</p>
<ul>
<li>Scapula Reduction</li>
<li>Clavicle Shortening</li>
<li>Thoracic Feminization/Reduction / Full Ribcage Resection (no clear name yet for it, getting tried on a cadaver soon last I checked) - TL;DR: remove strip of cartilage either side of sternum and secure with absorbable plates and screws </li>
<li>Lower rib resection w/ costal flare reduction</li>
<li>Floating rib fracture and reset or removal</li>
<li>Pelvic plasty, possibly (Ti illiac augmentation + silicone hip implants)</li>
<li>Maybe a modified form of triple pelvic osteotomy and other pelvic reconstruction, if it can be developed for us</li>
</ul>
<p>Surgery worked everywere else HRT couldn't so far, why not try it here? If I pull this off maybe I can be 99% cured, and these techniques can be spread if developed. I am nuts enough to go first if I can fund it, and have been doing insanely dangerous work with that goal, sustaining multiple injuries along the way. I am dysphoric AF and will do almost anything to get free. People say I'm just "wormed" badly... they have no fucking idea. I was "wormed" enough to troon out as a kid in the 00s... of course I'm going to fight till no worm remains. Once made whole through the power of bright lights, cold steel, and another day or two of propofol pseudo brain death, my powers will no longer be dissapated by physical dysphoria. I hope I can help lots of tranners get better thereafter. If any of my body can be recovered after whatever brings about my untimely demise someday, I hope I can be studied in a pro-trans lab to enhance future trannies.</p>
</div>
</div>
<div style="margin-left: 60px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/atillathetwink</strong> • 2 points
</div>
<div>
<div class="md"><p>Yeah that "thoracic feminization" is what I'm interested in. I've never heard anything about it except for one other person on here mentioning it. Do you have any other sources of information about it you could share with me? The fact that it needs to be tested on a cadaver implies its still very theoretical which sucks, I was under the impression that it was close enough to surgeries that are already performed on cis people that it was decently well understood already. Also, is there reason to believe it would even do much? It seems like there can't possibly be enough cartilage to remove to actually make a big enough difference in size. I guess it's probably pretty unrealistic for me to expect it to fix me but I'm still really curious if you have any more info. And huge respect for your surgerymaxxing plan btw I wish you the best of luck.</p>
</div>
</div>
<div style="margin-left: 80px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/Intelligent-Tea-2058</strong> • 1 points
</div>
<div>
<div class="md"><p>Basically a U.S. surgeon with some others, a Chinese thoracic surgeon, and maybe one other team are each working towards it in some way. I am concerned some of the EOs and intimidation will limit how much one once-interested medical system will provide.</p>
<blockquote>
<p>It seems like there can't possibly be enough cartilage to remove to actually make a big enough difference in size.</p>
</blockquote>
<p>Apparently 1 inch of circumference per side seems possible, perhaps more especially paired with other things.</p>
<p>I'll DM you.</p>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/atillathetwink</strong> • 1 points
</div>
<div>
<div class="md"><p>so wait, are you for or against clavicle shortening? you imply you don't think it looks good but also imply its good because it doesn't center the male gaze?</p>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/Important_Ad_7416</strong> • 1 points
</div>
<div>
<div class="md"><p>what if I have a small ribcage?</p>
<p>Ive seen a girl who went from inverted triangle to hourglass with clavique alone</p>
</div>
</div>
<div style="margin-left: 20px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/TheForceOfEvil</strong> • 1 points
</div>
<div>
<div class="md"><p>What are your measurements? Regardless of your size I hope your surgeon does a good job so you dont end up with slouchy undefined shoulders and no collarbones, because thats worse than having 2 extra inches imo.</p>
</div>
</div>
<div style="margin-left: 40px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/Important_Ad_7416</strong> • 1 points
</div>
<div>
<div class="md"><p>42.5cm bideltoid, 74cm underbust, 66-69 waist, 90 hips </p>
<p>tbhon i couldnt care less about how undefined my shoulders are so long as they're small</p>
</div>
</div>
<div style="margin-left: 60px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/TheForceOfEvil</strong> • 2 points
</div>
<div>
<div class="md"><p>I Actually have similar measurement! 70cm with 40cm. Honestly it depends on your height and weight? I think gaining a bit of weight for me to round up hips could be enough plus I am 174cm so I think it can be proportional. </p>
<p>ALSO remember wide shoulders are needed to have an hourglass body shape unless youre going for a pear shaped body, regardless of your goals if you can afford it(aka Starbucks or amazon insurance) and truly want it go get it but make sure they do a good job cuz some of the results Ive been seeing have been looking awful. </p>
<p>I just dont want girls to be basically hunting a stereotypical look of femininity. Just because society tells you you need to be small and submissive to be a worthy woman that doesnt mean you have to actually do it ❤️❤️❤️</p>
</div>
</div>
<div style="margin-left: 80px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/Important_Ad_7416</strong> • 1 points
</div>
<div>
<div class="md"><p>mogged 😓</p>
<p>im too broke for it and living in europe, im just gonna put on weight snd hope for the best</p>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
<div style="margin-left: 0px; border-left: 3px solid #ddd; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/46XX_</strong> • 1 points
</div>
<div>
<div class="md"><p>Broad shoulders are literally pretty? bulky ones just aren't bc they add alot of visual mass😭</p>
</div>
</div>
<div style="margin-left: 20px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/Important_Ad_7416</strong> • 3 points
</div>
<div>
<div class="md"><p>that's gonna be my cope</p>
<p>haha so pretty, so stunning, i love being build like a coathanger just like a man i mean model, i love looking like that and dont seethe when i see girls with tiny shoulders that match their hips</p>
</div>
</div>
<div style="margin-left: 40px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/46XX_</strong> • 0 points
</div>
<div>
<div class="md"><p>Having broad but "lean" shoulders isn't being build like a man, that what most models have😭</p>
<p>Them being bulky n broad is manly.</p>
</div>
</div>
<div style="margin-left: 60px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/Important_Ad_7416</strong> • 1 points
</div>
<div>
<div class="md"><p>Ok but I'm 163cm I'm never pulling off the model look and also dont like it 😓</p>
</div>
</div>
</div>
</div>
</div>
<div style="margin-left: 20px; border-left: 3px solid #eee; padding: 10px; margin: 10px 0; background: #fafafa;">
<div style="font-size: 0.9em; color: #666; margin-bottom: 5px;">
<strong>u/whattheerm</strong> • 1 points
</div>
<div>
<div class="md"><p>In the 80s sure</p>
</div>
</div>
</div>
</div>

File diff suppressed because it is too large Load Diff

View File

@ -0,0 +1,280 @@
<meta charset='utf-8'>
<base target='_blank'>
<style>
body{font-family:system-ui,sans-serif;max-width:50rem;margin:2rem auto;line-height:1.6;padding:1rem}
img,iframe{max-width:100%}
.post-content{background:#f9f9f9;padding:1rem;border-radius:5px;margin:1rem 0}
.archive-header{background:#f0f8ff;border:1px solid #e0e0e0;border-radius:5px;padding:0.75rem;margin-bottom:1rem;font-size:0.9rem}
.archive-info{margin-bottom:0.5rem;color:#666}
.archive-source{color:#666}
.archive-header a{color:#007acc;text-decoration:none}
.archive-header a:hover{text-decoration:underline}
@media (prefers-color-scheme: dark) {
.archive-header{background:#1a1a2e;border-color:#333;color:#e0e0e0}
.archive-info, .archive-source{color:#ccc}
.archive-header a{color:#66b3ff}
}
</style>
<div class="archive-header">
<div class="archive-info">
<strong>📄 Archived:</strong> 2025-08-10 15:45:40 UTC
</div>
<div class="archive-source">
<strong>🔗 Source:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/15894038/">https://pubmed.ncbi.nlm.nih.gov/15894038/</a>
</div>
</div>
<script>
// Archive metadata for cache management
window.archiveData = {
url: 'https://pubmed.ncbi.nlm.nih.gov/15894038/',
archivedAt: "2025-08-10T15:45:40.218512+00:00Z",
timestamp: 1754840740218
};
</script>
<hr>
<h1>Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application</h1>
<html><body><div><div class="article-details" id="article-details">
<div class="abstract" id="abstract">
<h2 class="title">
Abstract
</h2>
<div class="abstract-content selected" id="eng-abstract">
<p>
Cortisol is involved in the distribution and deposition of fat, and its action is regulated by the activity of 11beta-hydroxysteroid dehydrogenase. Glycyrrhetinic acid, the active principle of licorice root, blocks 11beta-hydroxysteroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes. We evaluated the effect of topical application of a cream containing glycyrrhetinic acid in the thickness of fat at the level of the thigh. Eighteen healthy women (age range 20-33 years) with normal BMI were randomly allocated to treatment, at the level of the dominant thigh, with a cream containing 2.5% glycyrrhetinic acid (n=9) or with a placebo cream containing the excipients alone (n=9). Before and after 1 month of treatment both the circumference and the thickness of the superficial fat layer of the thighs (by ultrasound analysis) were measured. The circumference and the thickness of the superficial fat layer were significantly reduced in comparison to the controlateral untreated thigh and to control subjects treated with the placebo cream. No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol. The effect of glycyrrhetinic acid on the thickness of subcutaneous fat was likely related to a block of 11beta-hydroxysteroid dehydrogenase type 1 at the level of fat cells; therefore, glycyrrhetinic acid could be effectively used in the reduction of unwanted local fat accumulation.
</p>
</div>
</div>
<div class="publication-types keywords-section" id="publication-types">
<h2 class="title">
Publication types
</h2>
<ul class="keywords-list"><li>
Clinical Trial
</li><li>
Randomized Controlled Trial
</li></ul>
</div>
<div class="mesh-terms keywords-section" id="mesh-terms">
<h2 class="title">
MeSH terms
</h2>
<ul class="keywords-list"><li>
Adipose Tissue / drug effects*
</li><li>
Administration, Topical
</li><li>
Adult
</li><li>
Body Composition / drug effects*
</li><li>
Body Mass Index
</li><li>
Body Weight / drug effects
</li><li>
Female
</li><li>
Glycyrrhetinic Acid / administration &amp; dosage
</li><li>
Glycyrrhetinic Acid / adverse effects
</li><li>
Glycyrrhetinic Acid / pharmacology*
</li><li>
Glycyrrhiza uralensis*
</li><li>
Humans
</li><li>
Subcutaneous Tissue / drug effects*
</li><li>
Thigh* / diagnostic imaging
</li><li>
Time Factors
</li><li>
Ultrasonography
</li></ul>
</div>
</div>
</div></body></html>

View File

@ -0,0 +1,340 @@
<meta charset='utf-8'>
<base target='_blank'>
<style>
body{font-family:system-ui,sans-serif;max-width:50rem;margin:2rem auto;line-height:1.6;padding:1rem}
img,iframe{max-width:100%}
.post-content{background:#f9f9f9;padding:1rem;border-radius:5px;margin:1rem 0}
.archive-header{background:#f0f8ff;border:1px solid #e0e0e0;border-radius:5px;padding:0.75rem;margin-bottom:1rem;font-size:0.9rem}
.archive-info{margin-bottom:0.5rem;color:#666}
.archive-source{color:#666}
.archive-header a{color:#007acc;text-decoration:none}
.archive-header a:hover{text-decoration:underline}
@media (prefers-color-scheme: dark) {
.archive-header{background:#1a1a2e;border-color:#333;color:#e0e0e0}
.archive-info, .archive-source{color:#ccc}
.archive-header a{color:#66b3ff}
}
</style>
<div class="archive-header">
<div class="archive-info">
<strong>📄 Archived:</strong> 2025-08-10 15:45:40 UTC
</div>
<div class="archive-source">
<strong>🔗 Source:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/17524126/">https://pubmed.ncbi.nlm.nih.gov/17524126/</a>
</div>
</div>
<script>
// Archive metadata for cache management
window.archiveData = {
url: 'https://pubmed.ncbi.nlm.nih.gov/17524126/',
archivedAt: "2025-08-10T15:45:40.522127+00:00Z",
timestamp: 1754840740522
};
</script>
<hr>
<h1>Evaluation of the effects of caffeine in the microcirculation and edema on thighs and buttocks using the orthogonal polarization spectral imaging and clinical parameters</h1>
<html><body><div><div class="article-details" id="article-details">
<div class="abstract" id="abstract">
<h2 class="title">
Abstract
</h2>
<div class="abstract-content selected" id="eng-abstract">
<p>
Gynoid lipodystrophy, also known as cellulite, is a common multifactorial entity that affects millions of women around the world. There have been few scientific articles dealing with its physiology and treatment in the past few years, and vascular changes seem to play an important role in its pathophysiology. Skin microvascular alterations can be observed noninvasively with a new method called orthogonal polarization spectral imaging, which was used to evaluate the effectiveness of an anticellulite drug composed mainly of a 7% caffeine solution. Microcirculatory parameters evaluated were functional capillary density (FCD; number of flowing capillaries per unit area), diameter of the dermic papilla (DPD), and capillary diameter (CD). The clinical parameters analyzed were centimetrical measurements of thighs and hips and the influence of tobacco, alcohol, and physical activities on the efficacy of the treatment. After 1 month of treatment, statistical application of chi-squared and Z approximation tests showed, in treated patients, statistically significant reduction of thigh circumferences in more than 80% of the cases and reduction of hip circumference in 67.7%. FCD, DPD, and CD did not change significantly after treatment. Smoking as well as alcohol consumption and regular physical activity were not significantly related to the centimetrical reduction observed in treated thighs and hips.
</p>
</div>
</div>
<div class="publication-types keywords-section" id="publication-types">
<h2 class="title">
Publication types
</h2>
<ul class="keywords-list"><li>
Clinical Trial
</li><li>
Research Support, Non-U.S. Gov't
</li></ul>
</div>
<div class="mesh-terms keywords-section" id="mesh-terms">
<h2 class="title">
MeSH terms
</h2>
<ul class="keywords-list"><li>
Adipose Tissue / blood supply
</li><li>
Adipose Tissue / drug effects
</li><li>
Adipose Tissue / pathology
</li><li>
Administration, Topical
</li><li>
Adult
</li><li>
Alcohol Drinking
</li><li>
Buttocks
</li><li>
Caffeine / administration &amp; dosage
</li><li>
Caffeine / pharmacology*
</li><li>
Edema / drug therapy
</li><li>
Edema / pathology
</li><li>
Exercise
</li><li>
Female
</li><li>
Humans
</li><li>
Microcirculation / drug effects*
</li><li>
Microscopy, Polarization / methods
</li><li>
Obesity / drug therapy*
</li><li>
Skin / blood supply
</li><li>
Skin / pathology
</li><li>
Smoking
</li><li>
Thigh
</li></ul>
</div>
</div>
</div></body></html>

View File

@ -0,0 +1,75 @@
<meta charset='utf-8'>
<base target='_blank'>
<style>
body{font-family:system-ui,sans-serif;max-width:50rem;margin:2rem auto;line-height:1.6;padding:1rem}
img,iframe{max-width:100%}
.post-content{background:#f9f9f9;padding:1rem;border-radius:5px;margin:1rem 0}
.archive-header{background:#f0f8ff;border:1px solid #e0e0e0;border-radius:5px;padding:0.75rem;margin-bottom:1rem;font-size:0.9rem}
.archive-info{margin-bottom:0.5rem;color:#666}
.archive-source{color:#666}
.archive-header a{color:#007acc;text-decoration:none}
.archive-header a:hover{text-decoration:underline}
@media (prefers-color-scheme: dark) {
.archive-header{background:#1a1a2e;border-color:#333;color:#e0e0e0}
.archive-info, .archive-source{color:#ccc}
.archive-header a{color:#66b3ff}
}
</style>
<div class="archive-header">
<div class="archive-info">
<strong>📄 Archived:</strong> 2025-08-10 15:45:40 UTC
</div>
<div class="archive-source">
<strong>🔗 Source:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/26082579/">https://pubmed.ncbi.nlm.nih.gov/26082579/</a>
</div>
</div>
<script>
// Archive metadata for cache management
window.archiveData = {
url: 'https://pubmed.ncbi.nlm.nih.gov/26082579/',
archivedAt: "2025-08-10T15:45:40.747550+00:00Z",
timestamp: 1754840740747
};
</script>
<hr>
<h1>Efficacy of Slimming Cream Containing 3.5% Water-Soluble Caffeine and Xanthenes for the Treatment of Cellulite: Clinical Study and Literature Review</h1>
<html><body><div><div class="abstract-content selected" id="eng-abstract">
<p>
<strong class="sub-title">
Background:
</strong>
Cellulite is a 'cottage cheese-like' cutaneous change caused by subcutaneous fat bulging into the dermis that usually leads to cosmetic problems. Slimming cream containing 3.5% water-soluble caffeine and xanthenes exhibits a lipolytic effect with penetration into the dermis.
</p>
<p>
<strong class="sub-title">
Objective:
</strong>
To evaluate the efficacy and safety of slimming cream for the treatment of cellulite.
</p>
<p>
<strong class="sub-title">
Methods:
</strong>
Fifteen subjects with cellulite applied slimming cream to the thighs and inner side of the upper arms twice daily for 6 weeks. Efficacy was assessed using a standard visual scale, changes in the circumferences of the thighs and upper arms, and patient satisfaction by a questionnaire at baseline, week 3, and week 6. Safety was assessed by inquiring about adverse events through questionnaires.
</p>
<p>
<strong class="sub-title">
Results:
</strong>
The standard visual scale score improved significantly by 0.49 points (19.8%) at week 6. Thigh and upper-arm circumferences decreased by 0.7 cm (1.7%) and 0.8 cm (2.3%), respectively, at week 6. Slight itching and transient flushing were commonly reported, but no serious adverse event occurred.
</p>
<p>
<strong class="sub-title">
Conclusion:
</strong>
The slimming cream tested appears to be effective for the treatment of cellulitis without serious adverse effects. However, additional large clinical trials are required to confirm the efficacy and safety of slimming cream for the treatment of cellulitis.
</p>
</div>
</div></body></html>

View File

@ -0,0 +1,188 @@
<meta charset='utf-8'>
<base target='_blank'>
<style>
body{font-family:system-ui,sans-serif;max-width:50rem;margin:2rem auto;line-height:1.6;padding:1rem}
img,iframe{max-width:100%}
.post-content{background:#f9f9f9;padding:1rem;border-radius:5px;margin:1rem 0}
.archive-header{background:#f0f8ff;border:1px solid #e0e0e0;border-radius:5px;padding:0.75rem;margin-bottom:1rem;font-size:0.9rem}
.archive-info{margin-bottom:0.5rem;color:#666}
.archive-source{color:#666}
.archive-header a{color:#007acc;text-decoration:none}
.archive-header a:hover{text-decoration:underline}
@media (prefers-color-scheme: dark) {
.archive-header{background:#1a1a2e;border-color:#333;color:#e0e0e0}
.archive-info, .archive-source{color:#ccc}
.archive-header a{color:#66b3ff}
}
</style>
<div class="archive-header">
<div class="archive-info">
<strong>📄 Archived:</strong> 2025-08-10 15:45:41 UTC
</div>
<div class="archive-source">
<strong>🔗 Source:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/27060936/">https://pubmed.ncbi.nlm.nih.gov/27060936/</a>
</div>
</div>
<script>
// Archive metadata for cache management
window.archiveData = {
url: 'https://pubmed.ncbi.nlm.nih.gov/27060936/',
archivedAt: "2025-08-10T15:45:41.020788+00:00Z",
timestamp: 1754840741020
};
</script>
<hr>
<h1>A novel selective RF applicator for reducing thigh circumference: a clinical evaluation</h1>
<html><body><div><div class="article-details" id="article-details">
<div class="abstract" id="abstract">
<h2 class="title">
Abstract
</h2>
<div class="abstract-content selected" id="eng-abstract">
<p>
The demand for noninvasive body contouring procedures continues to drive the development of new technology to treat areas on the body that are more resistant to diet and exercise. This study assesses the safety and efficacy of a novel selective RF applicator as a noninvasive, contactless method for reducing thigh circumference using a radiofrequency electric field (Vanquish Flex Applicator, BTL Industries Inc., Boston, MA). Forty-two female subjects were enrolled to undergo a treatment of their bilateral inner and outer thighs (saddle bags) once weekly for 4 weeks. Thigh circumference was measured at the baseline and 2 weeks after the fourth treatment. The primary objective was the evaluation of clinical outcomes of 40 treated subjects. Safety of the device was assessed based on adverse events reports during the course of the study. Forty subjects completed the study. After four treatments, the therapy group showed a statistically significant (p &lt; 0.001) reduction in thigh circumference of 2.43 cm compared with an untreated control group of 10 patients, where no change was seen (p = 0.297). No treatment associated pain or discomfort was reported by the subjects. There were also no reports of adverse events. This study demonstrates that the contactless RF Applicator is safe, painless and effective for the circumferential reduction of the thighs.
</p>
</div>
<p>
<strong class="sub-title">
Keywords:
</strong>
body contouring; radiofrequency; subcutaneous tissue/panniculitis/lipodystrophy.
</p>
</div>
<p class="copyright" id="copyright">
© 2015 Wiley Periodicals, Inc.
</p>
<div class="mesh-terms keywords-section" id="mesh-terms">
<h2 class="title">
MeSH terms
</h2>
<ul class="keywords-list"><li>
Adult
</li><li>
Cosmetic Techniques* / instrumentation
</li><li>
Female
</li><li>
Humans
</li><li>
Middle Aged
</li><li>
Radio Waves / adverse effects
</li><li>
Radiofrequency Therapy*
</li><li>
Thigh*
</li><li>
Treatment Outcome
</li><li>
Young Adult
</li></ul>
</div>
</div>
</div></body></html>

View File

@ -0,0 +1,44 @@
<meta charset='utf-8'>
<base target='_blank'>
<style>
body{font-family:system-ui,sans-serif;max-width:50rem;margin:2rem auto;line-height:1.6;padding:1rem}
img,iframe{max-width:100%}
.post-content{background:#f9f9f9;padding:1rem;border-radius:5px;margin:1rem 0}
.archive-header{background:#f0f8ff;border:1px solid #e0e0e0;border-radius:5px;padding:0.75rem;margin-bottom:1rem;font-size:0.9rem}
.archive-info{margin-bottom:0.5rem;color:#666}
.archive-source{color:#666}
.archive-header a{color:#007acc;text-decoration:none}
.archive-header a:hover{text-decoration:underline}
@media (prefers-color-scheme: dark) {
.archive-header{background:#1a1a2e;border-color:#333;color:#e0e0e0}
.archive-info, .archive-source{color:#ccc}
.archive-header a{color:#66b3ff}
}
</style>
<div class="archive-header">
<div class="archive-info">
<strong>📄 Archived:</strong> 2025-08-10 15:45:41 UTC
</div>
<div class="archive-source">
<strong>🔗 Source:</strong> <a href="https://www.sciencedirect.com/science/article/abs/pii/S0006291X12005384">https://www.sciencedirect.com/science/article/abs/pii/S0006291X12005384</a>
</div>
</div>
<script>
// Archive metadata for cache management
window.archiveData = {
url: 'https://www.sciencedirect.com/science/article/abs/pii/S0006291X12005384',
archivedAt: "2025-08-10T15:45:41.194761+00:00Z",
timestamp: 1754840741194
};
</script>
<hr>
<h1>ScienceDirect</h1>
<html><body><div><div class="card-content" data-astro-cid-mn752ggz=""> <h1 class="u-h2" data-astro-cid-mn752ggz="">There was a problem providing the content you requested</h1> <div class="u-margin-m-bottom" data-astro-cid-mn752ggz=""> <p class="u-margin-m-bottom">
Please
<a class="anchor anchor anchor-secondary anchor-medium anchor-underline" href="https://service.elsevier.com/app/contact/supporthub/sciencedirect/" target="_blank"><span class="anchor-text-container"><span class="anchor-text"> <span class="anchor-text">contact our support team</span> </span><svg aria-label="Opens in new window" class="icon icon-arrow-up-right-tiny arrow-external-link" focusable="false" viewbox="0 0 8 8"><path d="M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z"></path></svg></span></a>
for more information and provide the details below.
</p> <ul> <li><strong>Reference number: </strong>96d09f289f0363e6</li> <li><strong>IP Address: </strong>213.152.255.185</li> <li id="userAgent"> <li id="timestamp"> </li></li></ul> <p>
::CLOUDFLARE_ERROR_1000S_BOX::
</p> </div> </div> </div></body></html>