117 lines
4.5 KiB
HTML
117 lines
4.5 KiB
HTML
<meta charset='utf-8'>
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<base target='_blank'>
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<style>
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body{font-family:system-ui,sans-serif;max-width:50rem;margin:2rem auto;line-height:1.6;padding:1rem}
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img,iframe{max-width:100%}
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.post-content{background:#f9f9f9;padding:1rem;border-radius:5px;margin:1rem 0}
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.archive-header{background:#f0f8ff;border:1px solid #e0e0e0;border-radius:5px;padding:0.75rem;margin-bottom:1rem;font-size:0.9rem}
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.archive-info{margin-bottom:0.5rem;color:#666}
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.archive-source{color:#666}
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.archive-header a{color:#007acc;text-decoration:none}
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.archive-header a:hover{text-decoration:underline}
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@media (prefers-color-scheme: dark) {
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.archive-header{background:#1a1a2e;border-color:#333;color:#e0e0e0}
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.archive-info, .archive-source{color:#ccc}
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.archive-header a{color:#66b3ff}
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}
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</style>
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<div class="archive-header">
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<div class="archive-info">
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<strong>📄 Archived:</strong> 2025-08-31 11:56:15 UTC
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</div>
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<div class="archive-source">
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<strong>🔗 Source:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/23732711/">https://pubmed.ncbi.nlm.nih.gov/23732711/</a>
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</div>
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</div>
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<script>
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// Archive metadata for cache management
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window.archiveData = {
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url: 'https://pubmed.ncbi.nlm.nih.gov/23732711/',
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archivedAt: "2025-08-31T11:56:15.848119+00:00Z",
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timestamp: 1756641375848
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};
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</script>
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<hr>
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<h1>Sunscreen and prevention of skin aging: a randomized trial</h1>
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<html><body><div><div class="abstract-content selected" id="eng-abstract">
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<p>
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<strong class="sub-title">
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Background:
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</strong>
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Sunscreen use and dietary antioxidants are advocated as preventives of skin aging, but supporting evidence is lacking.
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</p>
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<p>
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<strong class="sub-title">
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Objective:
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</strong>
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To determine whether regular use of sunscreen compared with discretionary use or β-carotene supplements compared with placebo retard skin aging, measured by degree of photoaging.
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</p>
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<p>
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<strong class="sub-title">
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Design:
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</strong>
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Randomized, controlled, community-based intervention. (Australian New Zealand Clinical Trials Registry: ACTRN12610000086066).
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</p>
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<p>
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<strong class="sub-title">
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Setting:
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</strong>
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Nambour, Australia (latitude 26° S).
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</p>
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<p>
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<strong class="sub-title">
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Patients:
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</strong>
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903 adults younger than 55 years out of 1621 adults randomly selected from a community register.
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</p>
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<p>
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<strong class="sub-title">
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Intervention:
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</strong>
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Random assignment into 4 groups: daily use of broad-spectrum sunscreen and 30 mg of β-carotene, daily use of sunscreen and placebo, discretionary use of sunscreen and 30 mg of β-carotene, and discretionary use of sunscreen and placebo.
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</p>
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<p>
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<strong class="sub-title">
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Measurements:
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</strong>
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Change in microtopography between 1992 and 1996 in the sunscreen and β-carotene groups compared with controls, graded by assessors blinded to treatment allocation.
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</p>
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<p>
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<strong class="sub-title">
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Results:
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</strong>
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The daily sunscreen group showed no detectable increase in skin aging after 4.5 years. Skin aging from baseline to the end of the trial was 24% less in the daily sunscreen group than in the discretionary sunscreen group (relative odds, 0.76 [95% CI, 0.59 to 0.98]). β-Carotene supplementation had no overall effect on skin aging, although contrasting associations were seen in subgroups with different severity of aging at baseline.
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</p>
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<p>
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<strong class="sub-title">
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Limitation:
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</strong>
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Some outcome data were missing, and power to detect moderate treatment effects was modest.
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</p>
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<p>
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<strong class="sub-title">
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Conclusion:
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</strong>
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Regular sunscreen use retards skin aging in healthy, middle-aged men and women. No overall effect of β-carotene on skin aging was identified, and further study is required to definitively exclude potential benefit or potential harm.
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</p>
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<p>
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<strong class="sub-title">
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Primary funding source:
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</strong>
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National Health and Medical Research Council of Australia.
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</p>
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</div>
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</div></body></html> |