CJC-1295 Peptide: Benefits, Dosage, Risks, and Where to Buy
+
+
[Disclaimer: This article is for informational and educational purposes only. CJC-1295 is not FDA-approved for human consumption and is currently only available for research purposes. The information provided does not constitute medical advice.]
+
CJC-1295 is closely connected to human growth hormone (HGH or GH), a key hormone in your body that controls growth and development.
+
Your body uses GH for much more than just getting tallerāit helps build muscle protein, burns fat more efficiently, boosts energy levels, and makes workouts more productive.
+
These benefits make GH optimization important for everyone, regardless of your age.
+
Many biohackers consider CJC-1295 peptide one of the safest and most effective compounds for boosting your natural GH production. This guide will show you everything you need to know about CJC-1295 and its proper use.
+
+
What is CJC-1295? Does CJC-1295 Work?Ā Ā Ā Ā
+
CJC-1295 is a modified version of something your body already produces called growth hormone-releasing hormone (GHRH).
+
It was originally developed by ConjuChem Technologies, a Canadian biotech company, which is where it gets its name.
+
You might hear people refer to it as āCJC-1295 DACā or āDAC: GRFā ā donāt let these technical terms confuse you. The āDACā part (drug affinity complex) is just a special modification that helps the peptide last longer in your body.
+
While researchers are still conducting human clinical trials to fully understand its benefits, CJC-1295 has caught the attention of the athletic and medical communities, which often seek the best peptides for athletic performance.
+
Theyāre interested in CJC-1295 because early research suggests it could improve body composition, potentially helping people build muscle and lose fat more effectively.
+
It offers similar benefits to traditional growth hormone treatments but with fewer side effects.
+
+
Sermorelin vs. CJC-1295
+
Sermorelin, also known as GHRH 1-29, is another GHRH analog that works similarly to CJC-1295.
+
However, there are some key differences:
+
+
Half-life: Sermorelin lasts only 11ā12 minutes, while CJC-1295, due to the DAC technology, has a half-life of around 5.8 ā 8.1 days.
+
Dosing Frequency: Sermorelin must be taken daily, whereas CJC-1295 only requires 1-2 doses per week.
+
Strength: With its longer half-life, CJC-1295 exhibits greater strength and potency than sermorelin.
+
Side Effects: CJC-1295 tends to produce fewer side effects since it mimics natural GHRH more closely.
+
+
Can You Take CJC-1295 and Sermorelin Together?
+
While technically possible, no research supports additional benefits from combining these peptides.
+
Since CJC-1295 is essentially an enhanced version of Sermorelin, using them together would likely be redundant.
+
Tesamorelin vs. CJC-1295Ā
+
Tesamorelin is another growth hormone-releasing peptide that is typically used to reduce excess abdominal fat in HIV patients.
+
Hereās how the two compare:
+
+
Tesamorelin has a shorter half-life of ~26ā38 minutes.
+
CJC-1295 produces more sustained hormone elevation.
+
Tesamorelin use is associated with elevated glucose and HbA1c levels, which isnāt seen with CJC-1295.
+
Tesamorelin (Egrifta) is FDA-approved for specific medical use.
+
CJC-1295 is currently only available for research purposes.
+
+
BPC-157 vs. CJC-1295
+
BPC-157 is a different type of peptide that consists of 15 amino acids.
+
BPC-157 has local effects, such as healing leaky gut, speeding injury recovery, and protecting against damage from NSAIDs.
+
These peptides serve different purposes:
+
+
BPC-157 primarily promotes healing and tissue repair
+
CJC-1295 focuses on growth hormone release and associated benefits
+
+
They can potentially be used together as their mechanisms donāt conflict.
+
+
CJC-1295 DAC vs. No DAC
+
Hereās how the two versions compare:
+
+
+
+
Aspect
+
CJC 1295 DAC
+
CJC 1295 No DAC
+
+
+
Purpose
+
Increases GH/IGF-1 levels for an extended period
+
Increases GH/IGF-1 levels briefly
+
+
+
Duration of Action
+
Effects last 6-8 days after injection, with IGF-1 elevated for up to 28 days
+
Effects peak within 1-2 hours and decline rapidly
+
+
+
Frequency of Injections
+
1-2 times weekly
+
Daily
+
+
+
Formulation
+
CJC-1295 + Drug Affinity Complex (DAC)
+
CJC-1295 peptide only (No DAC modification)
+
+
+
Half-Life
+
5.8-8.1 days
+
~30 minutes
+
+
+
+
What Does CJC-1295 Do?
+
A study by Teichman and his team in 2006 showed just what a single CJC-1295 injection can do:
+
+
It can boost your growth hormone (GH) levels by 2 to 10 times their average amount, lasting almost a week. Higher GH levels mean your body becomes more efficient at building muscle and burning fat.
+
The injection also increases your IGF-1 (Insulin-like Growth Factor 1) levels by 1.5 to 3 times for up to 11 days. IGF-1 is your bodyās natural anabolic steroid ā a hormone that helps build and preserve muscle tissue.
+
When you take multiple doses, your IGF-1 levels can stay elevated for up to 28 days!
+
+
+
CJC-1295 Benefits
+
Based on the activity we just mentioned and some small-scale studies and animal research, here are the benefits CJC-1295 provides:
+
Build & Maintain Muscle Mass More Effectively
+
CJC-1295ās ability to boost both growth hormone and IGF-1 levels makes it perfect for muscle growth.
+
The peptide helps stimulate protein synthesis (building new muscle) and supports overall muscle mass development.
+
Youāll find CJC-1295 in many peptides for muscle growth listicles.
+
Get Better Sleep Quality
+
If youāre struggling with sleep, CJC-1295 might help you rest better.
+
Since itās a synthetic version of GHRH (growth hormone-releasing hormone), which plays a crucial role in sleep quality, researchers are excited about its potential.
+
A thorough study by Fehm and colleagues investigated this connection.
+
They conducted a double-blind study (meaning neither researchers nor participants knew who received what) with 23 healthy men ā 12 young and 11 older subjects.
+
Each participant received 300 micrograms of GHRH or a placebo 30 minutes before bedtime.
+
The results for the GHRH group were:
+
+
Lower cortisol levels at the beginning of sleep (cortisol is your stress hormone)
+
Better control of growth hormone levels during early sleep
+
Increased REM sleep (crucial for mental recovery)
+
More slow-wave sleep (SWS) in the latter half of the night (vital for physical recovery)
+
+
Quality sleep helps your muscles recover from injury, and growth hormones have been shown to improve non-REM sleep after periods of sleep deprivation.
+
+
Shed Stubborn Body Fat
+
Studies have found that prolactin (a hormone in your body) can increase visceral fat ā the stubborn fat around your organs.
+
CJC-1295 has been shown to help normalize prolactin levels, as examined in studies with GHRH knockout mice. This normalization could lead to better fat burning in your body.
+
Boost Your Brain Power & Performance
+
Growth hormones donāt just affect your muscles and fat ā they play a role in how well your brain works, particularly in learning and memory.
+
In an animal study, researchers found that mice with enhanced growth hormone activity performed notably better on learning tests than regular mice.
+
Note: Though these early results are promising, we need more research to understand how CJC-1295 affects humans entirely. Most of our current knowledge comes from animal studies, as this peptide is still in the research phase and hasnāt been extensively tested in humans for these specific benefits.
+
+
How CJC-1295 Peptide Works
+
Hereās what happens when you take/inject CJC-1295 peptide:
+
+
CJC-1295 enters your bloodstream and binds to albumin (a blood protein), which helps it stay active for 8-10 days.
+
It then travels to your pituitary gland and binds to receptors on special cells called somatotropes.
+
When bound to these receptors, it signals the cells to make more growth hormones.
+
The cells also release their existing growth hormone into your blood.
+
This leads to higher levels of both growth hormone and IGF-1 in your body.
+
Unlike synthetic growth hormone injections, CJC-1295 maintains your bodyās natural pulsing pattern of hormone release.
+
+
In simple terms, CJC-1295 tells your body to release the growth hormone it has stored and make more of it.
+
But GHRH (and therefore CJC-1295) doesnāt just affect your pituitary gland. Its effects reach throughout your body, influencing how cells grow and multiply in various tissues.
+
This wide-reaching impact is why cancer researchers are particularly interested in understanding how it works.
+
To give you an idea of how powerful CJC-1295 is, a 2005 study with male Sprague Dawley rats showed that it could stimulate a ā4-fold increaseā in growth hormone (GH) levels.
+
When researchers combined CJC-1295 with hGRF1ā29 amide and CJC-1288, they saw the biggest spike in blood growth hormone levels ever recorded in the rats in their two-hour testing window.
+
This means CJC-1295 not only worked well on its own but achieved record-breaking results when combined with other peptides!
+
+
CJC-1295 Dosage and Timing
+
Due to its extended half-life, CJC-1295 only needs to be injected 1-3 times per week for sustainable results.
+
Typical dosing protocols involve injecting 1-2 mg (1000-2000 mcg) per injection. Timing the injection before bed works well since natural GH release peaks during early sleep.
+
How Much CJC-1295 Should I Take?
+
Most clinical trials, like Teichman and his teamās research, have used body-weight-based doses of 30-60 mcg/kg injected once weekly.
+
If you weigh 80 kg (176 lbs), that equals 2,400-4,800 mcg (2.4-4.8 mg) per injection.Ā
+
Anecdotal evidence suggests splitting this dosage into smaller injections 2-3x weekly. It may help sustain consistent GH levels.
+
CJC-1295 Dosage for Weight Loss
+
No studies directly claim that CJC-1295 can help you lose weight without any external force.
+
However, one study published in the Growth Hormone & IGF Research journal shows that GH administration notably accelerates abdominal/visceral fat reduction.
+
Here is the dosage you can follow:
+
+
Starting dose: 1000mcg (1mg) weekly (DAC version)
+
Can be increased to 2000mcg based on the response
+
Best taken before bed on an empty stomach
+
+
Time injections before cardio workouts to further optimize your body composition.
+
+
CJC-1295 Dosage for Bodybuilding
+
Due to its ability to elevate IGF-1 (which stimulates muscle protein synthesis) and induce hyperplasia, a weekly CJC-1295 dosage of 1-2 mg (1000-2000 mcg) might increase muscle mass.
+
This dosage can be timed around your workout. Specifically, you can take one of your daily injections shortly after exercising when your body is primed for muscle growth and recovery.
+
Anti-aging clinics also frequently prescribe CJC-1295 alongside other peptides like sermorelin or ipamorelin for better outcomes.
+
Where to Inject CJC-1295
+
CJC-1295 is injected subcutaneously, meaning into fat tissue instead of muscle.
+
Good injection sites with looser skin that avoids veins/nerves include around the navel, love handles, outer thigh, or upper glute.
+
Ensure to fully inject the solution once the needle is under the skin rather than pulling in/out.
+
How Long Does CJC-1295 Take to Work?
+
If youāre using CJC-1295 DAC, youāll need some patience.
+
It typically takes 3-6 months to see an āupregulationāāwhen your pituitary gland starts producing consistently higher amounts of growth hormone.
+
Teichman and his colleagues found: after taking multiple doses of CJC-1295 DAC, people maintained elevated IGF-1 levels (a key marker of growth hormone activity) for up to 28 days, even after stopping the peptide.
+
The No DAC version works differently, but honestly, we have less human research to go on. However, studies on similar peptides (modified versions of GRF(1-29)) give us some clues:
+
+
Initial effects start quickly ā within 2 hours of taking it
+
Benefits remain consistent with daily use for up to 16 weeks
+
No studies have tested these peptides beyond 16 weeks
+
+
16 weeks might seem like a long time, but researchers are just being cautious ā they simply havenāt tested longer periods yet.
+
+
Peptide Therapy: CJC-1295 and IpamorelinĀ Ā Ā Ā Ā Ā
+
The combination of CJC-1295 and Ipamorelin represents one of the most studied peptide therapy protocols.
+
This combination works synergistically ā CJC-1295 maintains sustained growth hormone (GH) levels, while Ipamorelin creates powerful GH pulses by stimulating ghrelin receptors.
+
CJC-1295 Ipamorelin Side Effects
+
Despite the synergy, here are some common side effects to note:
+
+
Injection site reactions (redness, irritation)
+
Temporary water retention
+
Mild headaches
+
Tingling sensations
+
Increased hunger
+
+
Ipamorelin CJC-1295 Dosage
+
Studies mentioned above and anecdotal evidence typically follow these guidelines:
+
How Much CJC-1295 Ipamorelin Should I Take?
+
Standard dosages:
+
+
CJC-1295: 100mcg per day (No DAC version)
+
Ipamorelin: 100-200mcg per day
+
Administration: Split into 1-2 daily doses
+
+
CJC-1295 + Ipamorelin: Bodybuilding Dosage
+
For body composition:
+
+
CJC-1295: 60mcg/kg
+
Ipamorelin: 100mcg/kgĀ
+
Administration: Biweekly protocol for sustained effects
+
+
The same protocol applies when combining CJC-1295 and Ipamorelin for muscle growth.
+
CJC-1295 + Ipamorelin: How Long Does It Take to See Results?
+
Based on research protocols, results typically develop as follows:
+
+
Initial hormonal changes: 1-2 weeks
+
Noticeable composition changes: 4-6 weeks
+
Full benefits: 8-12 weeks
+
Effects can persist up to 28 days after administration
+
+
+
CJC-1295 Side Effects and Risks
+
Since CJC-1295 simply mimics natural GHRH, side effects tend to be mild.
+
The most common include redness or itching at the injection site and occasional headaches. Rarely, symptoms like fatigue, nausea, or dizziness may surface temporarily.
+
It doesnāt interfere with other hormone axes, either.
+
However, it hasnāt been studied in the long term, so theoretical risks like glucose instability, carpal tunnel syndrome, or cancer risk canāt be definitively ruled out.
+
One critical note for athletes:
+
CJC-1295 is strictly prohibited by the World Anti-Doping Agency (WADA).
+
If youāre a competitive athlete subject to drug testing, be aware that anti-doping authorities routinely screen for this peptide, and violations carry severe penalties.
+
The risk of detection and subsequent sanctions isnāt worth it.
+
Is CJC-1295 Safe for Long-Term Use?
+
No large-scale studies have evaluated CJC-1295 for longer than 16 weeks thus far. However, research on comparable GHRH analogs can infer its safety over extended periods.
+
For example, sermorelin has been clinically administered for over a decade with excellent safety data.
+
Since CJC-1295 works via a similar natural mechanism to increase GH levels, experts consider it to be as safe in the long term.
+
+
Frequently Asked Questions (FAQs)
+
Here are answers to some often-asked questions regarding CJC-1295 treatment:
+
How Quickly Will I See Results From CJC-1295?
+
Blood tests show an increase in GH and IGF-1 within hours after injecting CJC-1295. However, visible anti-aging effects and physique changes happen gradually over subsequent weeks and months.
+
It may take about 4-8 weeks before noticing substantial improvements to body composition, skin quality, energy levels, etc.
+
For those exploring peptides to enhance vitality, considering the best peptide for energy can provide insight into complementary options that may boost overall results.
+
What Happens When You Stop Taking CJC-1295?
+
Since CJC-1295 doesnāt supply external GH (it stimulates natural production instead), GH and IGF-1 levels naturally taper back to baseline within about one month after stopping treatment.
+
Depending on diet, you may regain some body fat, but muscle tissue and anti-aging effects should remain relatively persistent months later owing to lasting gene expression changes.
+
Does CJC-1295 Increase Testosterone?
+
There is no concrete evidence that CJC-1295 directly raises testosterone levels.Ā
+
However, downstream hormonal balance changes from higher GH & IGF-1 may support secondary boosts in luteinizing hormone, DHEA, and testosterone.
+
Conclusion
+
CJC-1295 seems like a promising option if youāre interested in growth hormone optimization and want benefits for body composition, recovery, and anti-aging.
+
While research is still ongoing, current evidence suggests itās generally safe and effective when used responsibly.
+
As with any peptide, proper dosing, cycling, and medical supervision are non-negotiable for optimal results and safety.
+
+
\ No newline at end of file
diff --git a/docs/sources/ihsoyct-github-io__index-html__2a460b067b.md b/docs/sources/ihsoyct-github-io__index-html__2a460b067b.md
new file mode 100644
index 0000000..d415300
--- /dev/null
+++ b/docs/sources/ihsoyct-github-io__index-html__2a460b067b.md
@@ -0,0 +1,150 @@
+*Archived 2025-08-06 17:14 UTC from https://ihsoyct.github.io/index.html?backend=artic_shift&mode=comments&author=Gloomy-Scarcity-2197&limit=100&sort=desc&body=adifyline*
+
+# Comments by u/Gloomy-Scarcity-2197 ā¢ containing 'adifyline'
+
+**/r/DIYaesthetics/comments/1gt4n3m/adifyline_purchasingvolume_guide/mkkr7so/**
+https://reddit.com/r/DIYaesthetics/comments/1gt4n3m/adifyline_purchasingvolume_guide/mkkr7so/
+
+u/Gloomy-Scarcity-2197 ā¢ 1 points ā¢ 2025-03-30 20:28 UTC ā¢ r/DIYaesthetics
+
+Good in both myself and my partner. She was lacking fat development more than I was and she saw visible increases in a month of usage in both face and breasts. Not dream-result, but significant.
+
+I saw smaller but still perceptible changes. The biggest difference was on the backs of my hands.
+
+We're both trans-feminine and I'm on the chunk side while she's skinny.
+
+I ended up using LotionCrafter as it comes a little bit more finished than AliBaba. Mixed 1ml of Adifyline with 1ml of Vasoline Cocoa Glow (mixing up about 20ml at a time). Applied to face, breasts and any leftovers to backs of hands.
+
+---
+
+**/r/45PlusSkincare/comments/1j3t3rt/what_can_i_do_next_routine_in_comments/mg2yz6d/**
+https://reddit.com/r/45PlusSkincare/comments/1j3t3rt/what_can_i_do_next_routine_in_comments/mg2yz6d/
+
+u/Gloomy-Scarcity-2197 ā¢ 1 points ā¢ 2025-03-05 02:55 UTC ā¢ r/45PlusSkincare
+
+These photos are only about a month apart. The big change is I actually started sticking to my routine instead of once a fortnight.
+
+I also let ChatGPT's research mode pair up skincare products with some of my medications and other goals. It may have been overkill but I actually understand what everything is doing now and have some plans to expand it. It also reminds me morning and night what I need to do :)
+
+The biggest practical change seems to be that my skin is healing and thickening resulting in a more even colour tone.
+
+Morning
+
+* Cleanse with Garnier PureActive
+* Adifyline
+* The Ordinary Multi-peptides with copper (this is new)
+* The Ordinary Hyaluronic acid
+* The Ordinary Vitamin C suspension 23% with HA spheres (this is new)
+* The Ordinary Niacinamide
+* Moisturise with Vasoline Cocoa Glow
+* La Roche-Posay Antihelios if I'm going outside or will be in the sun at all
+
+Night
+
+* Cleanse
+* Adifyline
+* Multi-peptide
+* Tretinoin
+* Moisturise
+
+I'm planning on getting a Derminator soon, and I'm also thinking about DMSO+Tret for areas of body skin that are too thick to achieve any structural changes.
+
+At some point I'll also try out C60 Buckyballs as they seem to be anti-aging magic or something.
+
+My main peeve at the moment is something the photo didn't manage to capture - there's tiny soft freckles all over my face but they're not distinct enough to be freckles so I just kind of look not washed in the wrong light. Any other suggestions on how to handle that?
+
+---
+
+**/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mc2nlb1/**
+https://reddit.com/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mc2nlb1/
+
+u/Gloomy-Scarcity-2197 ā¢ 2 points ā¢ 2025-02-10 20:29 UTC ā¢ r/45PlusSkincare
+
+>I'll be retesting with the tret soon so that's that covered.
+
+You can't "test" this stuff any more than you already have. Either you commit to using it for the required period to actually see a difference or don't bother I guess. You won't see decent results until you've used it for a couple of years consistently.
+
+>The adifyline I'll test on the cheeks and may be around the forehead then see how it's going.
+
+That isn't how that works either unfortunately. Your face will absorb it and it'll put the fat where your genetics said you should have had it as a teenager. The good news is that's everywhere that makes you look healthy and young.
+
+---
+
+**/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbyhh71/**
+https://reddit.com/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbyhh71/
+
+u/Gloomy-Scarcity-2197 ā¢ 1 points ā¢ 2025-02-10 03:25 UTC ā¢ r/45PlusSkincare
+
+Now we're talking.
+
+How long ago did you lose the weight? This looks like classic ozempic (or any other rapid weight loss) face. It takes a couple of years but your skin will tighten up in certain ways. Tret helps that happen faster (skin cell cycling + adds a ton of fresh collagen and elastin).
+
+For the rest, you can definitely look at adifyline to cover some bases as well.
+
+As I've said a few times, no single thing is the entire solution, but each thing gets you noticeably closer. As long as you're not expecting magic, it can happen.
+
+As you're a cis man, I'd also probably add a weak estrogen topical cream to that, but you need to be *very* careful here, as yes, misuse or not understanding dosages can cause breast buds to develop and not just softer skin. r/drwillpowers has mentioned his personal concoction a few times, and you can buy your own Estradiol Valerate from grey-market sites and carefully make your own lotion.
+
+---
+
+**/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbwimqr/**
+https://reddit.com/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbwimqr/
+
+u/Gloomy-Scarcity-2197 ā¢ 2 points ā¢ 2025-02-09 21:00 UTC ā¢ r/45PlusSkincare
+
+My weight moved around rather than losing any. Estrogen definitely helped in that regard, and it's known for seeming to wind back age a bit, but it's not nearly as effective in that regard as adifyline, with the main bonus being adifyline doesn't make you become a woman if you're a cis-gendered man.
+
+There's about ten major factors in everyone's age appearance rather than just one or two.
+
+I'm just hitting that age where I *should* be showing signs of aging and I've carefully addressed all of the sub-issues. Estrogen is just one of the things I had available to me.
+
+Given that adifyline is relatively cheap, and topical (so it's easy and non-invasive to use) and *fast* I'd always say try that for a couple of months first.
+
+---
+
+**/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbr6821/**
+https://reddit.com/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbr6821/
+
+u/Gloomy-Scarcity-2197 ā¢ 2 points ā¢ 2025-02-09 00:32 UTC ā¢ r/45PlusSkincare
+
+I mean, time matters. Start everything you should be doing NOW.
+
+Tret is the minimum, so it's good you're doing it, but there are other options you can try too.
+
+In the end, men age with a fair amount of dignity and you seem to be doing really well. I don't see any real negatives going on here, but if you MUST look young, search reddit or my post history for Adifyline.
+
+---
+
+**/r/45PlusSkincare/comments/1ijlh6h/estradiol_vaginal_cream/mblzglu/**
+https://reddit.com/r/45PlusSkincare/comments/1ijlh6h/estradiol_vaginal_cream/mblzglu/
+
+u/Gloomy-Scarcity-2197 ā¢ 3 points ā¢ 2025-02-08 04:53 UTC ā¢ r/45PlusSkincare
+
+My experience has been that if you already have estrogen in your system, this won't really help much.
+
+I have heard of men using a weak estradiol face cream to some effect, but if you have any amount of estrogen in you at all you're probably already getting the full benefit of it.
+
+It's a little new, but look into acetyl hexapeptide-38 (also known as adifyline) as a topical treatment for what you're trying to do. I used my hands to apply it to my face and after about a month both showed pretty good improvement. This peptide likes to stimulate fat rejuvenation in places that juvenile humans normally only have it, and it winds the clock back pretty good in some aspects like sagging and overall wrinkling from slack skin.
+
+---
+
+**/r/45PlusSkincare/comments/1h5i4kv/is_there_anything_i_should_work_on_47f/m08q41q/**
+https://reddit.com/r/45PlusSkincare/comments/1h5i4kv/is_there_anything_i_should_work_on_47f/m08q41q/
+
+u/Gloomy-Scarcity-2197 ā¢ 1 points ā¢ 2024-12-03 18:52 UTC ā¢ r/45PlusSkincare
+
+Adifyline from lotioncrafter
+
+---
+
+**/r/45PlusSkincare/comments/1h5i4kv/is_there_anything_i_should_work_on_47f/m08q1xl/**
+https://reddit.com/r/45PlusSkincare/comments/1h5i4kv/is_there_anything_i_should_work_on_47f/m08q1xl/
+
+u/Gloomy-Scarcity-2197 ā¢ 2 points ā¢ 2024-12-03 18:51 UTC ā¢ r/45PlusSkincare
+
+Lotioncrafter sell it. I mix it with 1 pump of moisturiser to every 1ml of serum and apply the same amount to each region I'm treating morning and night (apparently it also causes breast plumping so I use it there as well).
+
+On their site it's called adifyline. I searched around for clinical studies and only found one.
+
+---
+
diff --git a/docs/sources/mesityl-substack-com__p-mtf-weight-cycling__7aaae9d393.html b/docs/sources/mesityl-substack-com__p-mtf-weight-cycling__7aaae9d393.html
new file mode 100644
index 0000000..a8b269b
--- /dev/null
+++ b/docs/sources/mesityl-substack-com__p-mtf-weight-cycling__7aaae9d393.html
@@ -0,0 +1,38 @@
+
+
+
+
+
+
Weight cycling (WC) is the process of repetitively gaining and subsequently losing weight. In cisgender individuals weight cycling is often an unintended consequence of attempted weight loss followed by binge eating or, more simply, an inconsistency in eating habits over a prolonged period of time. It is also seen in bodybuilders/athletes who aim to build up lean muscle while keeping body fat percentage low.
While the research on WC is varied and sometimes even contradictory, it has been linked to an increased risk in kidney cancer (relative risk for weight cyclers vs. non-cyclers, 1.51; 95% CI, 1.16, 1.96), increased risk in developing diabetes (individuals who suffered weight cycling had a higher risk of diabetes, RR 1.23. 95% confidence interval 1.07ā1.41) but a less significant effect in individuals who are already diabetic (āThe majority of studies [13/17; 76%] did not show a detrimental effect of weight cycling on risk of type 2 diabetes.ā), among other possible correlations such as hypertension and mortality risk. In short, the area is still highly debated although generally speaking its probably not healthy. On an intuitive level, you will be stressing out your body through a continual calorie deficit or surplus. From a mental health perspective, individuals who unintentionally weight cycle are more likely to suffer from eating disorders (often BED and/or bulimia related) or depression.
Some studies say that WC causes an increase in central/abdominal fat. WC was seen to be correlated with a higher waist-to-hip ratio (WHR), although there seems to be no difference in the WHR of cyclers vs non-cyclers once BMI is taken into account [important!]. Some studies have shown that weight cycling is associated with an increased BMI/body mass [which could then maybe explain the observed increase in abdominal fatā¦], but multiple others have shown evidence to the contrary. It is hard to give a conclusive answer but if weight cycling is done intentionally you can finish cycling at whatever weight you feel comfortable with. Many repeated cycles /might/ shift more fat to the abdominal area in cis people, but maybe not.
MtF hormone replacement therapy (HRT) is known to change body fat from an android to a gynoid (female) distribution over time (and, interestingly, the actual blood estrogen levels did not correlate well with the degree of redistribution; genetics is probably the predominant factor here). This process is mediated by sex hormones through a variety of mechanisms that affect metabolic processes, levels of hormones such as leptin and ghrelin, fat cell proliferation, adipogenesis and lipolysis.
Estradiol selectively blunts lipolysis in certain areas while permitting it in others. Testosterone inhibits adipogenesis whereas estradiol promotes it and the fraction of SV cells that are early-differentiated adipocytes is ~35% greater in the femoral depot for women compared with men. In essence this indicates that both fat loss and fat gain will contribute towards a gynoid/female fat distribution when under the influence of female sex hormone levels. From this we can state with reasonable confidence that weight cycling will accelerate fat redistribution, a desirable trait for many MtFās.
Unfortunately, we have no peer-reviewed evidence for this theory (no doubt due to the niche and experimental nature of the subject). That being said, there is a swathe of anecdotal evidence supporting it and Dr. Will Powers, a well known endocrinologist, has written about it in the past.
If the above theory works as described, the faster the cycle the faster your fat will redistribute. The rate of weight loss does not significantly affect body composition, metabolism or hip circumference, waist circumference, WHR, BMI and fat-free mass. The only significantly affected metric was resting metabolic rate (WMD: 97.39 kcal, 95%
CI [78.78, 118.01]), which is an effect that may persist even if weight is regained. Very rapid weight loss may increase the chance of gallstone formation and resultantly it is recommended that no more than ~1.5kg is lost per week.
The turnover rate for adipocyte cells at a constant bodyweight is about 10% per year, with half of the adipocytes being replaced every ~8.3 years on average. At that rate fat redistribution would indeed be a rather slow process. However, due to weight cycling being both mentally and physically straining as well as diminishing returns, a large quantity of cycles is not recommended ā two to three cycles should be more than enough and anecdotal data seems to support this.
You lose weight when your calorific intake is lower than your total daily energy expenditure (TDEE). There is a large quantity of resources for weight loss available so I will not go into too much detail here, but will mention some things you might find useful.
It has been documented that strength training of specific muscles (e.g. the abdominals) prior to endurance training (e.g. a long cardio session) might be able to selectively burn fat in the corresponding area ā this could be useful when trying to achieve a lower WHR.
Ketogenic diets (when blood sugar is kept low and the body enters ketosis, metabolising fats instead of sugars to meet energy needs) will increase the rate at which body fat is burned and additionally have been shown to have a wide range of health benefits (Ref. 34, fascinating paper, would recommend reading).
During intermittent fasting, which comprises of restricting the daily eating time to a small window (e.g. eating a single big meal daily with no snacks inbetween), the body is also likely to enter a ketogenic state and is an effective strategy for weight loss (if you have the discipline for it).
A more extreme alternative, water fasting (not consuming any calories for a prolonged period) can likewise be practiced safely and responsibly if care is taken. The body will continue to burn fat to meet its energy needs (as long as you have fat to burn, although if you have low quantities of fat left your body will start to burn muscle ā this is the point at which it may become unsafe and thus fasting should only be practiced if you have a sufficiently high BMI to begin with), thus macronutrient deficiency is not a concern (perhaps counterintuitively). The bigger worry during fasting is micronutrient deficiency i.e. vitamins and electrolytes; a general purpose multivitamin supplement along with a low-sodium salt (which usually contains half NaCl and half KCl; you should aim for an intake of ~2g sodium and ~2g potassium daily) should suffice. When supplementing, methylfolate is preferable to folic acid and P5P or other forms of B6 are preferable to Pyridoxine. All that being said, if fasting is carried out responsibly it has the possibility to be very beneficial for the health ā reducing risk of metabolic syndrome, possibly preventing and helping to treat established tumors, improving cognition and stalling age-related cognitive decline (another captivating review paper that I would highly recommend taking a look at).
There is a whole range of supplements that could be beneficial when downcycling, some of which includeā¦
Acetyl-l-carnitine (ALCAR) is an orally bioavailable form of carnitine which is involved in the carnitine shuttle and is vital to fat metabolism. Supplementation has been shown to improve rates of fat metabolism and weight loss.
Water-soluble fibres such as Psyllium Husk or Glucomannan are effective at filling up the stomach/digestive tract and promoting a feeling of fullness, reducing appetite and promoting weight loss. In my personal experience this has been one of if not the most effective aid to weight loss. Care must be taken to drink enough liquid when using these supplements to avoid constipation.
Some investigational drugs exist for weight loss that were never put into market. Rimonabant, an inverse agonist of the CB1 receptor, significantly reduced appetite but clinical trials were halted after a 10% incidence rate of depressive symptoms and 1% incidence of suicidal ideation was observed. Beloranib, a METAP2 inhibitor, showed highly promising results for weight loss but stage 3 clinical trials were ceased after two patient deaths (unclear if caused by the drug itself).
A myriad of phenethylamine derivatives have been marketed and later withdrawn for weight loss, including amphetamine (1947-70ās), aminorex (1965-68), fenfluramine (1973-97), phenylpropanolamine (1976-2000), sibutramine (1997-2010) and mixtures of caffeine and ephedra (1994-2004) which combined with aspirin were known as the āECA stackā. Other related drugs include clenbuterol and aliphatic amines such as DMAA, DMHA and DMBA, which are all still both commonly used in body-building circles during weight cycles. Broadly speaking these are sympathomimetic drugs with stimulating properties, acting primarily as andrenergic receptor agonists (another examle of which is yohimbine) or dopamine/norepinephrine release promoters or reuptake inhibitors. Many of these will increase heart rate, body temperature and TDEE (for example 2-5% increase for ECA and 10-15% increase for clenbuterol are values I have seen being mentioned anecdotally). Conversely, many of them may have straining effects on the body, especially the cardiovascular system, and have the potential to be habit-forming and thus should be used with utmost care, if at all.
Thyroxine (T4) and Triiodothyronine/Liothyronine (T3) are the principle thyroid hormones and are essential for metabolic regulation and other related processes. Their supplementation can increase TDEE and body temperature, thus helping to reduce body weight. However, if thyroid hormone levels are too high there is a risk of hyperthyroidism or even thyrotoxicosis, meaning that thyroid levels should be monitored closely and utmost care be taken.
Glutide drugs such as Semaglutide or Liraglutide act as GLP-1 receptor agonists and promote weight loss through increasing insulin release, decreasing insulin resistance and decreasing excessive glucagon release. Their biggest downsides include very high price and the only viable RoA being injection.
A range of āfat bindersā exist, primarily lipase inhibitors, including pharmaceuticals such as Orlistat as well as a large quantity of patented plant-derived formulations such as those produced by the company XLS-medical. The latter can often be found highly overpriced in pharmacies and, even if they work to some degree, are essentially scams.
Dinitrophenol (DNP) is an uncoupling agent, causing large increases in body temperature and TDEE (around 11% increase per every 100mg taken). There have been 27 deaths from it since 2007 alone. There is a large variability in patient responsiveness to the drug and multiple have died even under clinical supervision. If you havenāt got the pointā¦ do not take this.
Acetyl-Hexapeptide-39 topically applied decreases PGC-1Ī± expression, diminishing adipogenesis and lipid accumulation as a consequence. The huge advantage here is the local effect of the drug, meaning it could potentially be used to selectively reduce fat in certain areas and thus improve WHR/fat distribution.
In a way opposite to downcycling, weight gain is achieved when your calorific intake is higher than your total daily energy expenditure (TDEE). This does not mean no exercise or junk food as both of these would have an adverse health effect. In my personal experience upcycling can be even more mentally straining than downcycling ā the feeling of guilt from purposefully eating large quantities of food or dysphoria felt from weight gain/tummy bloat is indeed unpleasant. The most important thing to remember is that these are all temporary and will help you achieve an ultimately better body in the long term!
Eating after you stop feeling full (instead of waiting to feel hungry) was effective for me, although it does take perseverance. Consuming calorie-dense fatty foods such as nuts, cheese and fatty meat together with something that increases your blood sugar (a modest quantity of carbs is better than sugar) and thus your insulin will promote deposition of fat and weight gain. Keep in mind that fat stores are about 8 times more energy dense than glycogen (carbohydrate stores), which itself will be about 2/3rds water weight; you want to minimise glycogen stores and ensure effective fat deposition is occurring to achieve your desired fat distribution. In short, donāt just eat a crapton of doughnuts and pastries.
Moderate alcohol consumption increases abdominal fat, worsening fat distribution, and increases plasma androgens in cisgender females. Therefore it is highly discouraged.
Just like with downcycling, there are a range of supplements that could be used to aid your upcycleā¦
Leucine and Argenine have been shown to be particularly effective at activating mTOR, a kinase that stimulates lipid synthesis and cell growth. Below is a graph showing proportions of amino acids contained within different foods:
Acetyl-Hexapeptide-38 topically applied increases PGC-1Ī± expression, stimulating adipogenesis and lipid accumulation as a consequence (in a way opposite to hexapeptide-39). Again, the local effect of the drug could be leveraged to selectively reduce fat in certain areas and thus improve WHR/fat distribution.
Volufiline is a patented cosmetic preparation containing Sarsapogenin which has been reported to stimulate adipocytic differentiation and adipogenesis by activation of PPAR-gamma. Similarly to the hexapeptide-38, it can be applied topically and perhaps even used synergistically.
Pioglitazone is an anti-diabetic medication that activates PPAR-gamma systemically, reducing insulin resistance, gluconeogenesis and overall blood sugar. High insulin resistance in transgender females is associated with android fat distribution/higher WHR. It has been shown to lower visceral fat and WHR even in patients whoās overall BMI remained the same. It seems to protect subcutaneous fat in a way similar to estrogen. There has even been one documented case of pioglitazone use to achieve female fat distribution in a transgender patient in the medical literature. The drug would probably be beneficial regardless of whether you are cycling or not. Out of everything I have mentioned this is in my opinion probably the single most effective tool for achieving female fat distribution.
I completed two cycles and am satisfied with the results, judging by my WHR and feeling happier with my body overall. The first downcycle had periods of intermittent fasting and ended with a two week water fast. I used hexapeptide-38 and pioglitazone during my second upcycle, and have been using clenbuterol and DMAA together with ALCAR and psyllium husk supplementation during my current second downcycle.
If you decide that weight cycling is the option for you, my best advice would be to not be too hard on yourself. Nothing you do can make you lose progress ā your fat distribution will always keep shifting in the right direction, the only thing you can affect is the rate at which that happens. Cheat days are fine and this should never take priority over the other things in your life, especially not your mental healthā¦
<3
\ No newline at end of file
diff --git a/docs/sources/muscleandbrawn-com__peptides-cjc-1295-peptide__55d94f57a3.html b/docs/sources/muscleandbrawn-com__peptides-cjc-1295-peptide__55d94f57a3.html
new file mode 100644
index 0000000..de8b8e1
--- /dev/null
+++ b/docs/sources/muscleandbrawn-com__peptides-cjc-1295-peptide__55d94f57a3.html
@@ -0,0 +1,43 @@
+
+
+
+
+
+
r/DIYaesthetics ā¢ by u/Gloomy-Scarcity-2197 ā¢ 6 points
+
Hello
+
I've been scrounging around for information regarding Adifyline/Acetyl Hexapeptide-38. I've only found one (slightly vague and not very reassuring with zero data) study in a cosmetology journal, but as it was referenced by the NIH I'm willing to give it a go.
+
Where is everyone purchasing it?
+
e.g. I found 1g/98% purity on AliBaba for $180USD. With the "recommended dosage" being 0.5mg, was that just for one application to the face? What about breasts?
+
Is this a good price? What's the likelihood that what I'm being sold is just cornflour?
+
Update: I remembered to check LotionCrafters so I ordered it from there. How many mg of Adifyline is in 15g of their product? 750mg?
+
+
+
Comments
+
+
+
+ u/Ok_Hat_2107 ā¢ 2 points
+
+
+
The lotioncrafters website says itās 0.05% active ingredient. Iād asked ChatGPT to do the math but itās a very small amount.
+
Running a similar experiment myself.
+
+
+
+
+
+ u/Gloomy-Scarcity-2197 ā¢ 2 points
+
+
+
My math was:
+
0.05% active ingredient in product
+15g = 750mg of active ingredient
+0.5mg/mL target dosage, with approximately 5mL used for face
+So 15g contains approx 5 months of product if used twice daily on face alone
+
That aligns with their recommendation to use 2% by volume each time for face/breasts. It doesn't matter much how concentrated you make it, as long as you use that much each time and are able to make it reach all of your target areas.
+
The practical way to do all of that is simply to figure out how much carrier medium (moisturiser, etc) you want to mix it with, draw the right amount of active ingredient with a syringe (0.1-0.15mL) and mix it up before using it.
+
The clinical difference in results between 0.2mg/mL and 0.5mg/mL were low enough that it can become a safe margin of error.
+
I'll be using it on my breasts as well, similar area to my face, so in reality I have a month and a bit of product in what I've purchased. That's enough time to check for results according to the product guide.
+
And please don't rely on chat GPT for math work, it's constantly wrong :)
+
+
+
+
+
+ u/Ok_Hat_2107 ā¢ 3 points
+
+
+
Iāll be thrilled if it works. Check in in a month?
+
+
+
+
+
+ u/Gloomy-Scarcity-2197 ā¢ 3 points
+
+
+
Yup! Maybe two though as it'll take a month to arrive.
+
+
+
+
+
+ u/Impressive_Beat_2626 ā¢ 2 points
+
+
+
Update me!! š
+
+
+
+
+
+ u/Gloomy-Scarcity-2197 ā¢ 1 points
+
+
+
One week in I wasn't expecting anything yet. However my face is a tiny bit softer and my boobs are having growth tingles.
+
Realistically though ping me in two months.
+
+
+
+
+
+ u/Impressive_Beat_2626 ā¢ 1 points
+
+
+
Amazing! Love those tingles lol. Did you just add a tsp to a bottle of lotion? I could never figure out the ratio with adifyline from lotion crafter.
+
+
+
+
+
+ u/Impressive_Beat_2626 ā¢ 1 points
+
+
+
UpdateMe!
+
+
+
+
+
+
+
+ u/Warm_Pen_7176 ā¢ 1 points
+
+
+
Pinging early!
+
+
+
+
+
+ u/Gloomy-Scarcity-2197 ā¢ 1 points
+
+
+
My progress has been slow but evident.
+
My girlfriend's progress on the other hand has been fucking phenomenal. She was already going from nothing to a C cup in three months flat due to finally getting a blocker, but with AH38 it's pushing her forward even faster and literally filling in the gaps that hormones haven't affected yet.
+
About 30 days in now, I'll be posing comparison pics after 60 days.
+
+
+
+
+
+ u/Smooth_Training_1104 ā¢ 2 points
+
+
+
hello ik it's not 30 days yet but I'm curious ,if you have any updates so far?
+
+
+
+
+
+
+ u/Warm_Pen_7176 ā¢ 0 points
+
+
+
Blockers? M2F? If so then there isn't any way of attributing the growth to anything other than blockers and hormones.
+
I was really trying to believe this could work šŖ
+
+
+
+
+
+ u/Gloomy-Scarcity-2197 ā¢ 1 points
+
+
+
What utter rubbish. There are clinical results.
+
+
+
+
+
+
+
+
+
+
+
+
+
+ u/FoodieTech ā¢ 2 points
+
+
+
Youāre a lifesaver. Thank you.
+
+
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
how did the adiflyine go for you?
+
+
+
+
+
+ u/Ok_Hat_2107 ā¢ 1 points
+
+
+
Fail. It did nothing. Fun experiment though.
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
ah damn, how long did you try it/what did you mix it with
Good in both myself and my partner. She was lacking fat development more than I was and she saw visible increases in a month of usage in both face and breasts. Not dream-result, but significant.
+
I saw smaller but still perceptible changes. The biggest difference was on the backs of my hands.
+
We're both trans-feminine and I'm on the chunk side while she's skinny.
+
I ended up using LotionCrafter as it comes a little bit more finished than AliBaba. Mixed 1ml of Adifyline with 1ml of Vasoline Cocoa Glow (mixing up about 20ml at a time) into a pump bottle that gives about 1ml per pump. Applied 1ml to face, 1ml to breasts etc, and any leftovers to backs of hands twice a day.
+
I haven't ordered more yet but I'll get around to it at some point. I think my testing confirmed something I'd expected, which is it fills in existing fat reservoirs that you either had or would have had as a child/teenager, it doesn't wholesale just add fat to the area it's placed. So if you put it on your whole face/neck you won't end up looking weird. It's not a magic fat pen.
+
+
+
+
+
+ u/JustLocksmith2985 ā¢ 2 points
+
+
+
Did help with facial fat? Like cheek and undereye
+
+
+
+
+
+ u/Gloomy-Scarcity-2197 ā¢ 2 points
+
+
+
Yeah. It's like an over-all increase though. Like I keep saying, it only hits areas where you've lost it since being a teenager. It's basically turning back the clock a bit. It won't add it where you never had it (unless you've totally switched sex hormones as well)
+
+
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 2 points
+
+
+
oh fascinating, cool theory on the existing fat pad side, would love to chat more about this, can i dm you pls?
+
+
+
+
+
+ u/Gloomy-Scarcity-2197 ā¢ 3 points
+
+
+
Sure. There's a discord where a bunch of us hang out sharing tips and hacks and discussing stuff if you'd like to join that as well.
+ Reddit and its partners use cookies and similar technologies to provide you with a better experience. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform.
+ For more information, please see our
+ Cookie Notice
+ and our
+ Privacy Policy.
+
+
+
\ No newline at end of file
diff --git a/docs/sources/old-reddit-com__r-diycosmeticprocedures-comments-18onbl8-adifyline_update_ex__be0fa3abe5.html b/docs/sources/old-reddit-com__r-diycosmeticprocedures-comments-18onbl8-adifyline_update_ex__be0fa3abe5.html
new file mode 100644
index 0000000..13815a6
--- /dev/null
+++ b/docs/sources/old-reddit-com__r-diycosmeticprocedures-comments-18onbl8-adifyline_update_ex__be0fa3abe5.html
@@ -0,0 +1,890 @@
+
+
+
+
+
+
r/DIYCosmeticProcedures ā¢ by u/anniesiaccc ā¢ 48 points
+
Hey guys I originally posted back in October about ordering adifyline (hexapeptide) for 13$ online and started my daily protocol of topically applying basic lotion that i put the peptide in.
+For anyone who doesnāt know- adifyline, when applied topically to areas that maintain adipose-cutaneous fatty tissue- it will generate more fat to that area, so it can be used for breast cup growth, cheek volume, etc
+Well, I didnāt post my update because I made the choice of doing a diy CaHa (hyperdilluted) on my face, and the photos would reflect that as opposed to yielding true results.
+I do want to say, that using it on the breasts has made my boobs massive (I am 30 but have sported A cups/ small Bās my whole life until they drastically got bigger and fuller after about one month in using ritualistically, so last month in November they became and still are a heavy C.)
+I will also say, if you use this be cautious of where you apply if itās on your body because you will get bigger. If you want bigger hips this is your go to. I made the mistake of putting it on my butt and I feel like an hourglass and I donāt like it perhaps because I wasnāt ready for such a transition but I will literally be using lemon bottle or something (please shoot me recommendations) to reverse what I thought I wanted on certain areas š„“š«
+To anyone who has used, would love to hear if you experienced similar
+And to anyone curious feel free to ask questions
+Happy holidays, peace love and D-I- fucking -Y
+
+
+
Comments
+
+
+
+ u/Downtown-Trip3501 ā¢ 17 points
+
+
+
May I please see before and afters? So interested!
+
+
+
+
+
+
+ u/sakurababydoll ā¢ 12 points
+
+
+
why get a bbl when you can use adifyline š¤£
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
this made me laugh lool, did you try it?
+
+
+
+
+
+
+
+ u/KiwiAvocados ā¢ 13 points
+
+
+
Can you share your mixing ratio please?
+
+
+
+
+
+
+ u/ohuwish ā¢ 10 points
+
+
+
How did you find out about this? Iāve never heard of it
+
+
+
+
+
+ u/anniesiaccc ā¢ 18 points
+
+
+
I was big into researching peptides for anti aging and trying to find something for skin plumping for the last year and a half and finally came across a research study about Adifyline (Ill follow up with some links later but may need yāall to remind me!) however this wasnāt yet able to be purchased anywhere so I let I go.
+Then this October I kind of went down a similar rabbit hole after someone on this forum asked about it and a few users provided some links, in which one I clicked and purchased for 13 bucks :)
+For the sources Iād go to the search bar and type āadefylineā in this subreddit and youāll find it
+I believe the title was about sunken cheeks lol
+
+
+
+
+
+ u/badkittenatl ā¢ 7 points
+
+
+
Can you post those? And some before and afters?
+
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
oh this is so cool, would love to hear more about how adifyline has been since, and what actually seemed most promising for anti aging/skin plumping in the end from what you saw/read?
Work out. I mean you can grow more fat on your butt, yeah, but if you want it to stop sagging you're going to have to build that muscle. I've been doing it for 3 mo this months now 5 days a week and I'm just now starting to see more actual roundness to my butt again. Wish I could say the same about my boobs..... They're just pitiful.
+
+
+
+
+
+
+
+
+
+
+ u/fatal-prophecy ā¢ 17 points
+
+
+
WOW! That's unbelievable you were able to achieve such massive results non-surgically, let alone topically! I'm not accusing you of lying (what would be the point anyway) as this is the first time I've even heard of peptides being used for this purpose and being so effective. But holy shit it sounds like a miracle. I'm about to embark on this quest myself I mean there's nothing to lose at that kind of price. Did you buy it here @ lotioncrafter - the 8gs for $14?? And you just mixed it in with a lotion? That's crazy you could go from an A to a C cup with something so minimal like that. But I definitely want to try it now myself.
+
+
+
+
+
+ u/anniesiaccc ā¢ 12 points
+
+
+
Yes lotion crafter!!!! Thatās the stuff!
+I wasnāt able to see with clarity how it altered my face granted my fillers I did but, yeah, it made my body grow in 2 months MASSIVE. All I did was rub the lotion I put maybe 1/4th of the vial (it comes with. Dropper attachment for easy mixing) into a huge bottle of dove lotion and rub it on every day and sometimes before bed.
+Iām still adjusting to how I look but itās what I asked for so I can say it delivered. If you get it please let me know your journey & i wish you the best of beauty!! šš
+
+
+
+
+
+ u/fatal-prophecy ā¢ 9 points
+
+
+
That's sooo crazy you had such insane results. I'm happy for you but holy shit it seems like a genuine miracle, not just that it's topical but also in such a highly diluted form. Even lotioncrafter (and other sites) recommend a usage rate of 2% but it says their product is 0.05? I'm just so confused lol. But am gonna test it out anyway, it's not like there's much to lose...Hell I'd be overjoyed just to get a 1/2 cup size improvement. Tbh I was strongly considering buying the estrogen that transwomen use but supposedly there's serious risks with that soo yeah this would be way better lol.
+
+
+
+
+
+ u/theejswann ā¢ 3 points
+
+
+
What have been your results?
+
+
+
+
+
+
+ u/cybilinside ā¢ 2 points
+
+
+
Have you had any results?
+
+
+
+
+
+
+
+ u/FishMcBobson ā¢ 2 points
+
+
+
How much did you add to how much lotion please? Iād love similar results
+
+
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
how did this quest go? starting myself atm
+
+
+
+
+
+
+
+ u/Sarahlb76 ā¢ 8 points
+
+
+
Ok but if it increases fat, does it increase cellulite? Iām skinny fat. Like Iām super thin with cellulite. Iād love an actual butt but donāt want more cellulite!
+
+
+
+
+
+ u/anniesiaccc ā¢ 8 points
+
+
+
I donāt think it plays a role in cellulite any more than fat does as from what I understand cellulite is more so a result of fat dispersal and this peptide generates adipose tissue (cutaneous fat)
+
+
+
+
+
+
+ u/Status_Ad_4230 ā¢ 1 points
+
+
+
Lift weights. Dance. Getvthat booty
+
+
+
+
+
+
+
+ u/InvestigatorHot8127 ā¢ 7 points
+
+
+
I want to add to my butt. Do you just rub it on? Does it ever get uneven?
+
+
+
+
+
+ u/theejswann ā¢ 1 points
+
+
+
ššš¤£
+
+
+
+
+
+ u/InvestigatorHot8127 ā¢ 2 points
+
+
+
I still want to rub it on my butt. My butt could use a little more fat. šš
+
+
+
+
+
+
+
+
+ u/Curious-Cappuccino ā¢ 4 points
+
+
+
Wow! Do you know what happens if you stop using it? Will the effects diminish and go back to normal?
+
+
+
+
+
+ u/anniesiaccc ā¢ 7 points
+
+
+
I donāt know what happens after discontinuing except for my experience which was that it stayed and wonāt go away.. hah
+
+
+
+
+
+ u/theejswann ā¢ 3 points
+
+
+
How about now? Any change in the results? lol
+
+
+
+
+
+
+
+
+ u/Melodic-Psychology62 ā¢ 4 points
+
+
+
What a goddess send! I have used diy skin cream for years as itās so very easy and less expensive than store bought. Never found this company!
+
+
+
+
+
+
+ u/kvltWitch ā¢ 3 points
+
+
+
Wow so I was looking into adipeau cream but the reviews of the company being scammy scared me away. I think Iād like to try this! I read it only works where there are hair follicles, though.
+
Iām wondering if I microneedle first on places with few hair follicles if Iād get decent results. Iām looking specifically for my temples. Filler there hurts so badly šš
+
+
+
+
+
+ u/anniesiaccc ā¢ 3 points
+
+
+
I did on my face and noticed an instant effect.
+I canāt speak for the long term because I compromised my self experimentation on my face by being impatient and using ca-ha fillers, but I did the boobs routinely at least 6 weeks & butt like 3 times and I have always been thinner and now I am stuck with a curved bod
+
+
+
+
+
+ u/kvltWitch ā¢ 5 points
+
+
+
Wow!! Itās absolutely crazy that a topical can do that. I went to lotion crafters and I saw a bunch of additives that supposedly MELT fat too! Wild, Iām totally experimenting with both lol
+Thank you!!
+
+
+
+
+
+ u/anniesiaccc ā¢ 6 points
+
+
+
Melt?!? I need to know about this if it works!
+Iām a strong believer in āif it seems too good to be true, it likely is-ā
+Hence why I stand corrected with this
+I havenāt heard of fat melting topicals and am kinda skeptical but please dooo keep me updated on your journey if it works!
+Much love
Does seem too good to be true but I love being a guinea pig!
+I
+
+
+
+
+
+ u/Background-Limit-358 ā¢ 2 points
+
+
+
id love to be a guinea pig with you!!
+did you purchase?
+
+
+
+
+
+
+
+
+
+
+ u/Background-Limit-358 ā¢ 3 points
+
+
+
adipeau is by no means a scam. the founder is incredibly smart. iāve been using for 6 weeks and major changes in my face. look at his you tube aeducator
+
+
+
+
+
+ u/nerja07 ā¢ 1 points
+
+
+
I used it for 6 months with zero results
+
+
+
+
+
+ u/Background-Limit-358 ā¢ 1 points
+
+
+
were you applying it correctly ?
+
+
+
+
+
+ u/nerja07 ā¢ 1 points
+
+
+
Yes - I even contacted the owner for tips!!
+
+
+
+
+
+ u/Background-Limit-358 ā¢ 1 points
+
+
+
hmmmm
+
+
+
+
+
+
+
+
+
+
+
+ u/sakurababydoll ā¢ 2 points
+
+
+
thanks for sharing.this is super interesting. I wish they would be able to ship to Australia :(
+
+
+
+
+
+
+ u/Gingerpnw225 ā¢ 2 points
+
+
+
Welp, I had to order a small amount after reading this. I donāt have many areas that Iād want to add fat but I am almost 45 so wondering if I put a small amount on my cheeks, temples, if it could add some volume. Can you give us an idea of how much you add to your lotion or ratio of product?
+
+
+
+
+
+ u/SaintSiren ā¢ 4 points
+
+
+
The web site says the max recommended concentration is 2%
+
+
+
+
+
+
+ u/theejswann ā¢ 1 points
+
+
+
how did you do? the op said she added 1/4 of the vial to a big dove bottle of lotion.
+
+
+
+
+
+
+ u/m-rabia ā¢ 1 points
+
+
+
how did it work for you!?
+
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
how's the progress been in the end?
+
+
+
+
+
+
+
+ u/ohuwish ā¢ 2 points
+
+
+
So at the point your breast growth is at right now, do you still have to use the cream to maintain results or will they keep growing ?
+
+
+
+
+
+ u/anniesiaccc ā¢ 2 points
+
+
+
Nooo
+Itās like the fat cells are there, and wonāt go away..
+I havenāt used it in a month
+
+
+
+
+
+ u/ohuwish ā¢ 2 points
+
+
+
I just bought some! Iāll let you know how it goes
+
+
+
+
+
+ u/anncetta ā¢ 2 points
+
+
+
Updates??
+
+
+
+
+
+
+ u/theejswann ā¢ 1 points
+
+
+
How did it go???
+
+
+
+
+
+ u/ohuwish ā¢ 2 points
+
+
+
It didnāt work for me, used the whole vial and nothing
+
+
+
+
+
+ u/theejswann ā¢ 1 points
+
+
+
Dangit! Where did you apply it and for how long?
+
+
+
+
+
+ u/ohuwish ā¢ 1 points
+
+
+
On my butt I guess over a months time
+
+
+
+
+
+ u/Capable-Ice3402 ā¢ 2 points
+
+
+
did you use it in the same proportions as OP? It seems like she used 20-30% instead of recommended 2%?
+
+
+
+
+
+ u/ohuwish ā¢ 1 points
+
+
+
Yes
+
+
+
+
+
+ u/Capable-Ice3402 ā¢ 1 points
+
+
+
was it from lotioncrafter?
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ u/National_Ad9742 ā¢ 2 points
+
+
+
I wonder if this will work on plumping out my bone claw hands.
+Iāve been looking into things to help that. They are basically bones in a thin skin sleeve.
+
+
+
+
+
+ u/anniesiaccc ā¢ 3 points
+
+
+
Lmao I wondered that too out of curiosity
+It will build where hair follicles grow and precious subcutaneous fat has been stored
+My hands are still a double zero
+
+
+
+
+
+ u/stripeddogg ā¢ 1 points
+
+
+
Yeah, if you were applying with your fingers/hands wouldn't your fingers have gained some fat?
+
+
+
+
+
+
+
+
+ u/Big_Employment7919 ā¢ 2 points
+
+
+
this is amazing thanks for sharing
+
+
+
+
+
+
+ u/filthy_weeb_trash ā¢ 1 points
+
+
+
adifyline is pretty great. im trying to use it to put on more weight and while i dont know that its doing much on my legs damn if it isnt doing wonders for my face. i will say the leaner you are in an area the more noticeable it is though.
+
+
+
+
+
+ u/theejswann ā¢ 1 points
+
+
+
Wow! how many times have you used it so far? what areas of your face? I want to do cheeks. I wonder if I can use under eyes to plump there.
+
+
+
+
+
+ u/filthy_weeb_trash ā¢ 2 points
+
+
+
+
Wow! how many times have you used it so far? what areas of your face?
+
+
2 weeks full face, 2 weeks upper to mid cheek, 2 weeks upper cheeks and spot treatment to deal with asymmetry. its not an overnight miracle, but the gradual effects are noticeable.
+
+
I want to do cheeks. I wonder if I can use under eyes to plump there.
+
+
i have a friend who is applying it to his undereyes, from what ive seen of him it absolutely does something for them.
+
i hope you dont mind if i dont post my face here but heres a crop of my cheek area after a month and a week. progress is easy to miss if you dont take photos as a lot of it is subtle. evidently its doing something as i got asked for ID buying wine the other day, something i havent experienced in years.
Thank you! It's been 2 days and lotioncrafter hasn't even shipped my order yet. Which picture is which?Ā
+
+
+
+
+
+ u/filthy_weeb_trash ā¢ 1 points
+
+
+
latter is the more recent one. my source isnt lotioncrafter but lotioncrafter is probably your best bet.
+
+
+
+
+
+ u/theejswann ā¢ 1 points
+
+
+
Mine should be here tomorrow!!@ Did you use dmso? Do you think you friend would send you a before and after pict of his eyes cropped to share with me?
+
+
+
+
+
+ u/filthy_weeb_trash ā¢ 1 points
+
+
+
DSMO is stupidly bad for you, i recommend mixing into an aqueous lotion of your choice and itll work just fine at 2-5% concentration. ill ask him.
+
+
+
+
+
+ u/theejswann ā¢ 1 points
+
+
+
Mine just arrived! I'm a little nervous lol. What did you friend say about the pic?
+
+
+
+
+
+ u/filthy_weeb_trash ā¢ 1 points
+
+
+
i asked him and he hasnt really said yes or no lol, but i did link the thread
+
+
+
+
+
+ u/theejswann ā¢ 1 points
+
+
+
lol well thanks!
+
+
+
+
+
+
+
+
+ u/theejswann ā¢ 1 points
+
+
+
Also, how many times a day did you apply?
+
+
+
+
+
+ u/filthy_weeb_trash ā¢ 2 points
+
+
+
i do twice daily application of 5% adifyline in aqueous cream. another friend of mine says shes had good results with hers, and shes done 2% adifyline in aqueous cream for 2 months.
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ u/Ecstatic_Low_827 ā¢ 1 points
+
+
+
Does it make where you apply it get bigger slowly...so you have some control as to when to stop applying it?... Or do you wake up one day sorry that you applied it because it grows huge almost overnight? (which would be terrifying) To help- this is what I've researched:They say apple cider vinegar applied will make fat cells smaller- I haven't tried it though. There is also this weight loss cream that supposedly works: https://www.flexussports.com/products/amilean-fat-loss-lotion-with-2-aminophylline
+
+
+
+
+
+
+ u/adirik92 ā¢ 1 points
+
+
+
I have been trying this by adding a couple of drops adifyline to a moisturizer and applying it twice a day to my breasts and face and Iām surprised to confirm it is indeed working. In 2.5 weeks, my breast measurement grew by 3 cms (Iām always leveling on a tattoo on my back so Iām sure the measurement is accurate) and they feel and look bouncier. My face is also noticeably more plump, to the point that I will stop and apply it only to my under eyes for another week or two. Extremely happy with the results and curious to see whether it lasts if I discontinue using this peptide.
+
+
+
+
+
+ u/Throwmeawaythanks99 ā¢ 1 points
+
+
+
Hi, have the results lasted?
+
+
+
+
+
+
+ u/carveryjoie ā¢ 1 points
+
+
+
Where did you buy your adifyline?
+
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
keen to hear how this has developed since then for you?
+
+
+
+
+
+
+
+ u/stripeddogg ā¢ 1 points
+
+
+
are the results permanent? since it's fat I'm guessing it stays until you lose it?
+
+
+
+
+
+
+ u/kleopatra_kardashian ā¢ 1 points
+
+
+
Did you only gain weight in your breasts or overall?
r/DIYCosmeticProcedures ā¢ by u/Publixxxsub ā¢ 19 points
+
I have seen limited but very interesting reviews of adifyline on here but there is a serious lack of overall resources for this product - so I'm inviting anyone interested to follow this post and I will update.
+
I did what I consider to be a patch test where I mixed a couple of units with several ounces of lotion: no results but nothing negative either. What I plan on doing is using this raw and not diluting. I'm going to do a raw patch test as well first, using my hip area, one breast and maybe something very thin skinned such as my hands just to see how effectively this actually produces results.
+
The way I see it, if I use this raw material without lotion dilution and no results happen at all, this is probably the mostly snake oil that some people think it is. Scientifically I understand they do have documented results, but if it doesn't work for everyone then it very well may be a waste of diy money. We'll see!
+
4/6 - here for an update for anyone who saved! Full transparency, Iāve had some other stuff going on so I havenāt been as consistent as I wanted to be so I would say Iāve used this about twice a week BUT I decided to ONLY use it on my left top hand. The following Iām going to copy paste from my message explanations to someone just because itās easier :
+
Iām just bareeellly starting to get crepe skin there and I also figured it was a good control area. Only doing it to one hand as well. What Iāve seen so for though, is that it definitely does plump up the skin with a visible differenceā¦.but only for some time afterward and then it goes back to normal and looks identical to my other hand. Timeframe is less than 1 day before āback to normalā.
+
So, Iām trying to fight the feeling that this is more like those āplumpingā lip glosses, which basically just burn your lip for a little while and cause micro swelling before it heals and goes away - however the fact that this is supposed to work by actually increasing adipose tissue and is not that same method? That shouldnāt be going right back away.
+
I went on to explain that Iām thinking about dermarolling it next š
+
+
+
Comments
+
+
+
+ u/Extreme_Falcon9228 ā¢ 8 points
+
+
+
Yay! I am also experimenting. I diluted it in lotion. I just started so we'll see. Also only doing one breast. If I'm not lopsided by the end of the bottle I'm done lol
+
+
+
+
+
+ u/bri22any ā¢ 1 points
+
+
+
How long have you been using it for? And how long is it supposed to take to see results?
+
Iām having a hard time finding much in the way of info on it
+
+
+
+
+
+ u/Extreme_Falcon9228 ā¢ 2 points
+
+
+
I just started. Like a few days. And no idea how long it's supposed to take, I can barely find info. So I'm just being my own guinea pig
+
+
+
+
+
+ u/theejswann ā¢ 1 points
+
+
+
What are your results?
+
+
+
+
+
+ u/Extreme_Falcon9228 ā¢ 2 points
+
+
+
Wow I canāt believe itās been three months. My results are nothing lol
+
+
+
+
+
+ u/theejswann ā¢ 1 points
+
+
+
šššš I can't deal with all of these different results! How long did you stick with it? Where did you apply it? And did you mix in lotion? I'm on day 2 and I think I mixed more than i should have.
+
+
+
+
+
+ u/Extreme_Falcon9228 ā¢ 1 points
+
+
+
Iām still using it everyday. I applied to my butt and boobs. Mixed with lotion at whatever ratio the directions said, I donāt remember now
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
hey, did this or anything else work for you?
+
+
+
+
+
+ u/Extreme_Falcon9228 ā¢ 1 points
+
+
+
No it didnāt :(
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
ah no, how come and how long did you do it for? would love to chat more about this, can i dm you pls?
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ u/georgiebb ā¢ 3 points
+
+
+
I'll be really interested! I don't really understand how these things work, but I used volufiline on the backs of my hands and it really seems like it made a difference, and even after a couple of weeks of not putting any volufiline or moisturiser at all on my hands, they still look much better than before. On my face I feel like I'm seeing improvements too but not as dramatic as my hands. But I don't get how!
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
this is impressive, you seem to be one of the people who responds especially well. how have things been since?
+
+
+
+
+
+ u/georgiebb ā¢ 1 points
+
+
+
I've really felt like I've had an improvement in my face especially, and it feels like the effects are pretty long lasting. I do have quite thin skin so that might be a factor. But the volufiline seems to do a lot more for me than any other serum I've tried
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
oh fascinating, thanks for the update. would love to chat more about this, can i dm you pls?
+
+
+
+
+
+
+
+
+
+ u/bri22any ā¢ 2 points
+
+
+
Iām really interested to see your results! Please keep us updated
+
Iām torn between wanting to buy some and being completely sceptical because it sounds way too good to be true lol.
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
did you try it, if so how'd it go?
+
+
+
+
+
+
+
+ u/bri22any ā¢ 1 points
+
+
+
It hasnāt been very long butā¦anything to report yet? š
+
+
+
+
+
+ u/Publixxxsub ā¢ 1 points
+
+
+
Visibly? No lol. I will say that I do feel the slightest tingle of burning putting it on raw but no adverse skin effects yet at all. I've done it 3 times since posting in order to get a good gauge of time/applications
+
+
+
+
+
+
+
+ u/PreferenceCritical14 ā¢ 1 points
+
+
+
Any updates?
+
+
+
+
+
+ u/Publixxxsub ā¢ 1 points
+
+
+
Oh I forgot about this! Yeah that stuff does not work long term at all lol my final judgement is really the last update of the post - it kinda works like lip plumper and DOES seem like it has a few hours of very slight fill in, but then it goes away. I did not attempt to actually inject this anywhere, I do still have some though. But I've switched to Dr pen and hyaluronic acid which IS actually working and leaving gradual results š„° would def recommend
+
+
+
+
+
+ u/PreferenceCritical14 ā¢ 1 points
+
+
+
Cool, thanks for the update. I've been experimenting with Adifyline for the past couple of months. and I have noticed what seems to be some lipid accumulation. But I have also made a couple other adjustments that may be contributing as well. So I started perusing reddit again to see if any of the other few experimenters had any updates. I do plan to continue using this until I have completed the bottle. I did mix it with hyaluronic acid to apply, so perhaps the acid is making more of a contribution.
+
+
+
+
+
+ u/Publixxxsub ā¢ 1 points
+
+
+
Hmm interesting mix! I may that that as well
+
+
+
+
+
+ u/Karoline-Ma ā¢ 1 points
+
+
+
Have you tried Adipofill peptide too? (platinum skincare and Skin perfection are selling this one)
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
been looking at this, did you try it also?
+
+
+
+
+
+ u/Karoline-Ma ā¢ 1 points
+
+
+
Not yet, still on my list.. Have you tried any of them?
+
+
+
+
+
+
+
+
+
+ u/Karoline-Ma ā¢ 1 points
+
+
+
Have you tried Adipofill peptide too? (platinum skincare and Skin perfection are selling this one) Not sure if adipofill or adifyline is best
+
+
+
+
+
+ u/PreferenceCritical14 ā¢ 1 points
+
+
+
I have not tried Adipofill, need to look into that!
+
+
+
+
+
+ u/Karoline-Ma ā¢ 1 points
+
+
+
Otherwise are you happy with Adifyline? Where do you apply it in the face? I have some dynamic lines in forehead but not sure if it can be applied there. Otherwise I have smile lines and I guess coud be good to apply on cheecks too, and under eyes?... Just being mindful as people are saying to be careful not apply all over face/unwated places
+
+
+
+
+
+
+
+
+ u/TheKnown_Unknown ā¢ 1 points
+
+
+
how this this been since? keen to hear about the update
+
+
+
+
+
+
+
+ u/carveryjoie ā¢ 1 points
+
+
+
Whats your adifyline and hyaluronic ratio? šš½
r/DIYCosmeticProcedures ā¢ by u/filthy_weeb_trash ā¢ 13 points
+
this isnt advice to go and make this or anything given theres a whole bunch of unknowns around this particularly relating to PPARy agonist effects on blood vessels as well as cumulative effects of stem cell deprivation on organ and bone tissue, but ive been using a topical formulation of pioglitazone .08% + 5% adifyline solution in a hand sanitizer base on my thighs and upper cheeks the last couple months to gain volume and it looks like its working pretty well. ive gained 14 lbs doing it which seems like a lot and it is for sure, but my body is defintely fuller where ive been applying it. theres a distinct change in shape with more volume in those areas relative to other areas, not enough to completely reshape my face in that period, but enough that im feeling a lot more confident about my face and such. its possible that a substantial portion of the volume is due to water retention in these areas, but im praying that they continue to increase and i see no signs of edema. if thats the case then ive almost certainly created a substantial amount of new fat tissue in my cheeks and on my thighs and hips.
+
+
+
Comments
+
+
+
+ u/kazumicortez ā¢ 2 points
+
+
+
Now I'm interested, where do you get pioglitazone + AH38 and how do you prepare it?
+
+
+
+
+
+ u/filthy_weeb_trash ā¢ 6 points
+
+
+
pioglitazone is easy to get from online pharmacies in tablet form. i use raws but you gotta be more er, willing to dig around for that. might be good to start in anabolics sourcing circles. ah38 can be bought premade as adifyline solution from lotioncrafter, you can use it at 2% rather than 5% if you want it to go further given its only a 30% increase in efficacy from 2% to 5%.
+
as for how to prepare it, any tablets you buy will need to be crushed in a pestle and mortar designed for pill crushing. the contents of such a pill will almost certainly be the main active, lubricants, preservatives, and cellulose powder, so nothing too concerning but you may find residue from the excipients inevitable. once crushed into the finest powder you can get it, it should be gradually added to propylene glycol @ 20mg/ml (active ingredient/propylene glycol) to form the active solution. you will want a magnetic stirrer for this process, and you may find it difficult or slow to fully incorporate. you will then add this and your adifyline solution to your gel base in the given proportions using geometric dilution for consistent dosing. this will have to be done without the assistance of your magnetic stirrer as it will struggle with high viscosity fluids like polymer and cream bases.
+
+
+
+
+
+ u/Inevitable_Word_9958 ā¢ 1 points
+
+
+
I dmed you
+
+
+
+
+
+
+
+
+ u/Impressive_Beat_2626 ā¢ 2 points
+
+
+
Thank you for sharing and thatās awesome that youāre noticing those results. I had systemic subcutaneous fat loss (undesired!) as a bad reaction to radiofrequency. Iāve been trying many things to solve this, including pioglitazone. Do you mind if I dm you for some additional questions?
+
+
+
+
+
+ u/filthy_weeb_trash ā¢ 2 points
+
+
+
sure
+
+
+
+
+
+
+
+ u/Extreme_Falcon9228 ā¢ 2 points
+
+
+
Sorry, are you saying youāve gained 14 lbs just from the solution? Or while using the product, you also have gained 14 lbs as regular weight gain, some of which has accumulated in the areas youāve applied?
+
+
+
+
+
+ u/filthy_weeb_trash ā¢ 1 points
+
+
+
ive gained 14 lbs on it. the first 5 lbs came in the span of a week and was almost certainly largely water weight. on the other hand if you take too much pio you will know about it because your appetite will go through the roof. rn i eat fairly often because ive an active job and even a low dose of pio crashes my blood sugar in 2-4 hours after eating.
+
+
+
+
+
+
+
+ u/skanda22 ā¢ 1 points
+
+
+
Fascinating and thank you very much for sharing. Iām so happy that this seems to be working for you and Iāve subscribed to your post to see what others have to share. šāŗļø
+
+
+
+
+
+
+ u/Slow_Parfait5341 ā¢ 1 points
+
+
+
Got any links to some studies onĀ pioglitazone? I've never heard of it.
+
+
+
+
+
+ u/filthy_weeb_trash ā¢ 1 points
+
+
+
its a diabetes med with a bunch of other niche applications being explored. if you go digging through pubmed for topical pioglitazone or prompt perplexity it should give you interesting results. not many people actually want to gain fat with it though so, i dont think many people pay much attention to the idea of topical pio for this.
+
+
+
+
+
+
+
+ u/jesisphinx ā¢ 1 points
+
+
+
Thank you for sharing this
+
+
+
+
+
+
+ u/JustLocksmith2985 ā¢ 1 points
+
+
+
May i ask an update for this? I wanna use on my undereye hollow
CJC-1295 w/DAC effect on breast growth and surgery recovery
+
r/DrWillPowers ā¢ by u/cyberpunk_trans ā¢ 11 points
+
Quick disclaimer: this post does not endorse self medicating with unregulated research chemicals. This is not a DIY post. This post is intended only to spur hypothetical, theoretical discussion regarding the role of GH and IGF-1 as it pertains to breast development and wound healing.
+
For those unfamiliar; CJC-1295 is a research peptide which temporarily increases the body's natural production of growth hormone (GH) and insulin-like growth factor (IGF-1). In theory - because it leverages the body's natural production instead of acting as an exogenous source of growth hormone - it makes supraphisiological levels within the body much less likely (and thus reduce the likelihood of scary side effects like acromegaly).
+
In online body building circles, this peptide is occasionally referenced as a way to speed up recovery from intense exercise, increase lean muscle mass and reduce body fat.
+
Hypothetically, would this peptide be relevant to speeding up post-surgical healing? For instance, if someone just had a major surgery that involved a lot of rearrangement of soft tissue? Is there existing data to suggest that increased GH and IGF-1 levels speed up surgical healing, which could be logically extended to hypothesize a similar effect from the application of this research peptide? Is there perhaps even anecdotal evidence of CJC-1295 being used in this context?
+
Likewise, it has been well-observed in this subreddit that there appears to be a potential correlation between IGF-1 levels and breast size. Theoretically, if other environmental factors are already optimal, could the application of this peptide potentially boost breast growth?
+
Again, I'm not suggesting that anyone go out and experiment with this, but knowing that there are people in the world who do take such risks, have we been able to gain any useful information from their experiences?
+
Edited to further clarify and distance this post from any endorsement or discussion of DIY.
+
+
+
Comments
+
+
+
+ u/[deleted] ā¢ 2 points
+
+
+
It had a positive effect for me when my physician prescribed it.
+
+
+
+
+
+ u/TRGlider ā¢ 1 points
+
+
+
Very interesting!! Do you mind if I ask a couple of questions? Under what circumstances did your doctor prescribed CJC 1295? Are you taking orally or by injection? If by injection to what part of the breast are you injecting if you are injecting of course. When you say it had a 'positive effect' how positive was it and did your breasts if in fact this is what you were taking it for get itchy like when we have growth spurts? Sorry for all of the questions but I'm quite interested personally. Thanks!
+
+
+
+
+
+ u/[deleted] ā¢ 2 points
+
+
+
By injection, 12 month course, injected into buttocks. Breasts increased 2 cup sizes that year.
+
+
+
+
+
+ u/TRGlider ā¢ 1 points
+
+
+
Thanks! Injected into buttocks intra muscular or subcutaneous? Did you cycle as in 5 days on and 2 days off for the entire year? Your information is greatly appreciated! Thank you!
"Despite the apparent necessity of GH/IGF-1 signaling in pubertal breast development however, women with Laron syndrome, in whom the growth hormone receptor (GHR) is defective and insensitive to GH and serum IGF-1 levels are very low, puberty, including breast development, is delayed, although full sexual maturity is always eventually reached.[15] Moreover, breast development and size are normal (albeit delayed) in spite of GH/IGF-1 axis insufficiency, and in some the breasts may actually be large in relation to body size.[15][16] The relatively large breasts in women with Laron syndrome have been suggested to be due to increased secretion of prolactin (which is known to produce breast enlargement) caused by a drift phenomenon from somatomammotrophic cells in the pituitary gland with a high GH secretion.[15][16] An animal model of Laron syndrome, the GHR knockout mouse, shows severely impaired ductal outgrowth at 11 weeks of age.[17][18][19] However, by 15 weeks, ductal development has caught up with that of normal mice and the ducts have fully distributed throughout the mammary fat pad, although the ducts remain narrower than those of wild-type mice.[17][18][19] In any case, female GHR knockout mice can lactate normally.[17][19] As such, it has been said that the phenotypes of women with Laron syndrome and GHR knockout mice are identical, with diminished body size and delayed sexual maturation accompanied by normal lactation.[17] These data indicate that very low circulating levels of IGF-1 can nonetheless allow for full pubertal breast development.[15][17]"
Skip to page 19: "the assay was validated by comparison with the positive control, pioglitazone, with which a 521% increase in differentiation stimulation was observed" - but that's in vitro, with 1.75% of volufiline
+
So doing some basic math, if we assume g0ldpunisher is right (hold that thought) and only 0.2% goes through the skin, you would need 500x the in-vivo dose to get 100%,of the effect (ie getting the 521% gains) and at least 9x to get to 1.9% (to be close to their 1.75%) if you then assume that there's some magic going on that makes the skin let 100% of the volufilne go through (which it wont, the skin is rly good at keeping stuff outside the body)
+
They talk about in vivo on page 26, and you'll see they start with a 5% cream (out of which we keep assuming 0.2% will make it through the skin, so far less than the 1.75% that's needed to reproduce the effect of pio in vitro) - but how much do they get by doing 2x instead of the 9x?
+
On table 6, after 56 day, they do get a significant difference: on average 5108 mm3 vs 5046 mm3.
+
Again, doing some basic math, this means (5108/5046)/5046 = .012 or about 1.2%
+
So there's some non linearity going on, and they can demonstrate a 1% volume gain - but it's something which requires a complex machine and that won't be visible to the naked eye!
+
They know it won't stand scrutiny, so they included a "best responders" subgroup, on top of which they fudge the results by comparing to the starting point, which masks any change from weight gain during the study (bc if I was offered to join a study with a compound that's increase boobage, ik I would def pig out to max out the effects!)
+
Doing some quick math, 521% growth in vitro, 1% volume gains in vivo, 1/521=0.0019 ... so omg we've demonstrated g0ldpunisher math was right: that's the ballpark of what we would expect, and it aint much: 0.2%
+
Read the whole paper, then read again g0ldpunisher comment, copied below, and you'lll understand that you need to get way more concentration to match pio, and at the price they sell volufiline you're better off getting the raws...
+
+
Volufine and topical ppar modulators do not work. One study showed only 0.2% of an already 2% solution of ach38 (volufine) made it through the dermis. It's wishful thinking sadly.
+
As for lifestyle factors they do indeed increase ppar expression and more importantly adiponectin. But the increase is a percentage of the increase seen in oral pioglitazone.
+
With regards to effects of different exercise modalities, aerobic exercise significantly increased adiponectin levels (MD: 0.83 Āµg/mL; 95% CI, 0.23, 1.42, p = 0.007, I2 = 89%) A statistically significant increase in adiponectin levels was found across all subgroups, but study heterogeneity remained high. Interestingly, for intervention duration, studies which lasted ā„12 weeks produced an approximately 5-fold higher increase in adiponectin levels than studies with longer duration (MD: 0.12 vs. 0.49 Āµg/mL). They saw a ~0.5 ug/mL increase in adiponectin with cardio.
Total and HMW adiponectin levels both rapidly increased within 3 days of pioglitazone treatment in all subjects and continued to increase throughout the study (total adiponectin 6.6 Ā± 1.0, 7.9 Ā± 1.2, 9.9 Ā± 1.6, 11.8 Ā± 1.9, and 13.7 Ā± 2.2 Ī¼g/ml [P < 0.05, repeated-measures ANOVA] and HMW adiponectin 4.3 Ā± 0.8, 5.2 Ā± 1.0, 7.0 Ā± 1.3, 8.4 Ā± 1.5, and 10.4 Ā± 1.9 Ī¼g/ml [P < 0.05] at days 0, 3, 7, 10, and 14, respectively).
+
Which is an increase of ~7ug/ml from pioglitazone in only 14days
This paper is not a study on the effects of Pioglitazone directly but a great analysis of the mechanism by which ppar modulators act on humans and mammals. We cannot draw any conclusions from such a paper about the effects of pioglitazone, however these are very much similar mechanisms by which this medication alters metabolism and visceral fat deposition.
+
"Weight loss or caloric restriction leads to increasing adiponectin levels, and this increase is associated with increased insulin sensitivity"
+
This effect of being chronically metabolically fit happens regardless of weight gain or existing BMI, an effect which is known to to be associated with a low and healthy WHR.
Going back to that animal study "Chronic exposure to a class of peroxisomal proliferator-activated receptor Ī³ (PPARĪ³) ligands known as thiazolidinediones can also increase serum adiponectin levels"
+
"In girls, increases in circulating estrogens occur during puberty onset and coincide with a marked increase in gluteofemoral SCAT fat deposition (45). The resulting āgynoidā fat distribution is typical of reproductive-aged women;" "Adult men have lower average body fat percentages compared with adult women. Despite these differences in total body adiposity, in adult men, abdominal VAT depots tend to be larger than in premenopausal women"
+
This paper shows how estrogen/testosterone directly affects where fat is deposited when it is gained in a metabolically healthy individual. It's my opinion that poor fat distribution after years of transfem HRT is more likely caused by metabolism than poor HRT or "genetic lottery" and cannot be as effectively fixed by diet or exercise, as it can be by increased adiponectin and ppar expression.
Thanks darth, so this means we should make a more concentrated āvolufilineā or a less concentrated version?
+
I have in my hands ah38 to play with, I was thinking on making a 1 mg/ml serum with it, as it seems is water soluble , I was thinking on trying first a batch with just pg, as a solvent and we already know pg is a penetration enhancer, maybe add some isopropyl miristate to enhance absorption too, let me know how many mg per ml ( like the actual dose will be 1 ml daily with this mg qty on it )
+
On another subject, I made a 5 mg/ml estriol serum, and used it daily for 7 days at night, it help with pore size, and I look younger, in just 7 days, but the recommended use is 10 mg 2 times a week, my question is, someone commented that estriol has antiestrogenic effects, so will my feminization be affected if I use it daily? Estriol in some studies, has de ability to prevent breast cancer in cis women, also helps with migraines and another benefits too, some trans women started their transition with estriol only and got good results ( even if estriol it is supposed to be 100 times weaker), and some used it scrotally too and it helped with breast growth too ( they were already on hrt for years ) , so right now Iām very confused , donāt know if still use it or not , cause honestly 7 days and seeing positive results is very promising , only side effect I got is that I didnāt have to use moisturizer on my face before this, now I need to, and it is supposed to be normal for cis woman to have drier skin , so it is not a bad side effect per se, thanks my friend , regards
+
+
+
+
+
+ u/darthemofan ā¢ 3 points
+
+
+
+
Thanks darth, so this means we should make a more concentrated āvolufilineā or a less concentrated version?
+
+
more concentrated: buy the raws, and mix it with volufiline (just to benefit from the solvents etc).
+
if the solubility allows it, I would aim for 2/3 raw 1/3 commercial (doing drop by drop to avoid precipitation)
+
+
I have in my hands ah38 to play with
+
+
I don't have any formula to suggest you which is why I suggest reusing existing commercial ones and boost them up :(
+
if you want to make a custom recipe, I would suggest checking on pubmed, and copy their formulas
+
+
I made a 5 mg/ml estriol serum, and used it daily for 7 days at night, it help with pore size, and I look younger, in just 7 days
+
+
so you mean science works?
+
like, you got the effects predicted from the existing research? how surprising lol!
+
it's like we don't talk shit on this sub lolol :)
+
+
the recommended use is 10 mg 2 times a week
+
+
recommended ... for whom? it's likely to be for cis women where it risks disrupting the HPG feedback loop and altering the menstrual cycle
+
+
someone commented that estriol has antiestrogenic effects, so will my feminization be affected if I use it daily
+
+
I don't have enough data, so I can't say, but if you are really worried, try to wash your face 5 minutes after applying it: this will only allow the shunt pathway (ie through hair follicules) maximizing the effect on follicules and therefore the pores, without allowing normal transdermal absorption
+
this method is used by men using E2 to regrow hair without systemic side effects (like boobs) and is supported by papers I read (search the sub for the shunt pathway)
+
+
right now Iām very confused , donāt know if still use it or not
+
+
TBH we don't have enough data. We can only speculate.
+
+
cause honestly 7 days and seeing positive results is very promising , only side effect I got is that I didnāt have to use moisturizer on my face before this
+
+
This is consistent with existing research, which mentions a dose dependent positive effect, yet at skin flux (doses) way above what commercial E3 allows (it's underdosed, bc its made for different reasons where risks to the HPG feedback are more important that skincare effects, something we dont care if on HRT)
+
What about you make a post with your recipe, and ask ppl to join in your dangerous experiment?
+
I'm many years post HRT and I'm fine experimenting on myself. so I'll join in and I'll let you know what kind of results I get (and there may be others who report that too!) but the more ppl the better!
+
+
+
+
+
+ u/Emmasissybisex ā¢ 1 points
+
+
+
Thanks friend, yes let me make a post with the recipe
+
+
+
+
+
+
+ u/Ok-Web9921 ā¢ 1 points
+
+
+
do you suggest anything to plump up the under eyes or lips or smile lines? I have zhi my from Amazon and volufine but the volufine mixed with aquaphor didn't work at all. tried for a month. any suggestions?
+
+
+
+
+
+
+
+ u/MooshyTendies ā¢ 1 points
+
+
+
Hey there, do you know where to source Sarsasapogenin in Europe? If not, any global online shop will do as an alternative. Thanks.
+
+
+
+
+
+ u/Emmasissybisex ā¢ 1 points
+
+
+
Hello, no, most of Europe suppliers I checked were branded ones , so prices are high , sorry
+
+
+
+
+
+ u/MooshyTendies ā¢ 1 points
+
+
+
Thank you for a fast reply. Could you recommend any US based online shops instead? I only found Zhi Mu extract on amazon and at hawaiipharm website, but I am unsure, if that extract is suitable and what to combine it with to get optimal dosage for daily use. The website says the following about it and I am not sure how to mix it into a DIY product:
The part about suggested use is also interesting. They assume it will be used orally. Would that make sense for a cis woman? I assume cis male should avoid it orally and only use topical application for treating facial fat loss.
+
+
Suggested use and dosage: Shake well before use. 20-30 drops, three times a day or as directed by your practitioner. The best way to use liquid herbal glycerites is to put the suggested amount in a glass of water, tea, or juice and drink the entire contents. Glycerites can also be administered directly into the mouth without the assistance of water however some glycerites are unpalatable which is why most people prefer to dilute them into a beverage.
+
+
Many users mention mixing volufiline with their moisturizer. Do they mean every time they apply it or can it be premixed into a larger container and used for a month instead? I saw in another comment of yours that someone mentioned that one could mix 3:1 raw SarsasapogeninĀ with trademarked Volufiline and another baseline moisturizer, such as one from Ordinary, where it is assumed that ordinary already optimized the mixture for better absorption through skin barrier.
+
+
+
+
+
+ u/Emmasissybisex ā¢ 1 points
+
+
+
Comes to mind lotioncrafter for adyfiline, you can check directly on made in china for the raw powders.
+
About the usage of those from hawaiipharm, I donāt really know what their focus is, we as transgirls are interested in those types of plants for the āvoluminizing effectā, so I would use it topically, BUT, you can also buy the raw powders of zhi mu, and all those plants ( I donāt know them all ), and just make the solution with glycerine like they do or with mct oil like they do, or as you please, and it will be a lot cheaper to DIY, than buying from them, I would think you can use also alcohol instead of glycerine or mct oil, you would have to check the solubility of those powders first, the problem with raw powders of plants, to my understanding, would be concentration doses, with something like acetyl hexapeptide 38, at least we know that adyfiline contained 0.05% of it , so adyfiline has 0.5 mg/ml in the solution , and they recommend to use just 2% of that solution for a final product, why? We donāt know , is it a marketing strategy? Is it for safety reasons? They wonāt tell us, remember, those are bussineses, bussineses need to make a profit always, they wonāt reveal the reality, in my experience and my own perspective , I think they use so little hexapeptide, because it is a very expensive chem, if they use a lot, a lot less clients will be able to afford it, but thatās just my perspective , I donāt know the real answer .
+
So take that in mind, and if you want a super cheap price, you will have to find suppliers in China, and you need to check for raws, not finished products, so depending on your needs you have to balanced out your pros and cons, yes, finished products will cost more, but are ready to use, and we canāt judge suppliers, everyone in this world needs to earn something to make profit. Hope this helps, have a great day
+
+
+
+
+
+ u/MooshyTendies ā¢ 1 points
+
+
+
So, to make a 2% solution of adyfiline from lotioncrafter would require me to add 50ml of oil/glycerine for every 1ml of adyfiline and a 100ml finished 2%-solution would contain only 1mg of acetyl hexapeptide-38? Is the math mathing? That does seem like a very low dosage. have you used it personally with any success?
+
It would be cheap. 60g of adyfiline would cost 70 USD before shipping and taxes and would end up, assuming 1mg=1ml, creating a 3000ml of final DIY product.
+
I'll need a more accurate scale:)
+
Would it make sense to combine acetyl hexapeptide-38 with Sarsasapogenin solution?
+
+
+
+
+
+
+
+
+
+
+
+ u/Lsomethingsomething ā¢ 2 points
+
+
+
Good to know, thank you. Sounds like that's another win for oral pioglitazone, then?
+
+
+
+
+
+ u/darthemofan ā¢ 3 points
+
+
+
yes
+
+
+
+
+
+
+
+ u/AltruisticNews8856 ā¢ 1 points
+
+
+
Acetyl Hexapeptide-38 is not the same as volufiline. I couldn't find any research on how much Volufilin is absorbed through the skin. If you have found it, you can send it to me. I am planning to use a dermaroller for better absorption of volufiline. I saw a woman on TikTok who used volufiline and dermaroller on her lips. At the end of the first month, her lips had grown significantly.
+
+
+
+
+
+ u/darthemofan ā¢ 1 points
+
+
+
+
I saw a woman on TikTok who used volufiline and dermaroller on her lips. At the end of the first month, her lips had grown significantly.
+
+
yes, that's another possibility: just try to use the pure raws as much as possible
+
ach38 and volufiline and pio are not the same, but the way they work seem close enough that we should expect they will behave the same
+
+
+
+
+
+
+ u/Tamulet ā¢ 1 points
+
+
+
+
I saw a woman on TikTok who used volufiline and dermaroller on her lips. At the end of the first month, her lips had grown significantly.
+
+
Don't suppose you have a link to this? I'm curious where exactly / how deep she rolled and how natural-looking the results were
+
+
+
+
+
+
+
+ u/Fun-Chemical4059 ā¢ 1 points
+
+
+
Thank you so much for your research on this . Iām going to try to make my own serum/oil with both the zhi mu and ach38 for under my eyes lips and necklines since itās my only concern so far with aging . Iām Really wishing I was better at math right now but Iāll figure it out from your other comments š
+
+
+
+
+
+ u/Ok-Web9921 ā¢ 1 points
+
+
+
how did it work out? did you make your serum? any results?
unrelated: Darth dangerous experiments: DIY shrink the rib cage with lower rib binding (akin to Kim K "corset diet")
+
r/estrogel ā¢ by u/darthemofan ā¢ 44 points
+
WARNING: the following may cause pain, costochondritis, cracked or fractured ribs, reduced lung capacity, lung or kidney damage from floating ribs etc. That's why it's called dangerous lol :) I'm no doctor. I'm just Darth from the internet who cooks drugs. Follow my advice at your own risks!
+
Intro: Darth dangerous experiments
+
I do not hide that I run various crazy experiments on myself. I just don't share results until I have a positive!
+
The last big one was the stop and go theory (cold stopping E2 to re-sensitize receptors) and it came after trying various crazy stuff, like domperidone (to increase PRL), dostinex (to reduce PRL), MK667 (for GH) etc. When I got a positive result, I shared it. Now after 2 other ppl have independently confirmed it worked for them, I can suggest it without reservations.
+
Now about ribs! Age is no guarantee of hip growth. I have had poor results. My dude is ftm and has had rib wrapping for binding. It's hard to describe, but when you run your fingers along his sexy ribs, you can feel like a change of level, like a dent all over.
+
It's often a problem for ftm bc binding can shrink the upper ribcage while they want to be buff, but for us mtf it's kinda interesting. So my goal was to try to "reproduce" the result, by doing everything that is said to be "binding dangerously", and see what works. After discussions with other people by PM, I started experimenting with a few things to improve my w/h ratio.
+
Extrapolating from ftm results
+
It is well known that even safe binding gradually deforms the ribs: the longer you bind, the more deformation can accrue.
+
Even then, lots of cis people say it's impossible to alter the shape of the ribcage: try to google shrinking the rib cage, and look at the dismissive answers from docs like on quora.
+
Personally, I'm ready to believe anything, but only with evidence - and I believe trans ppl more than cis ppl who pretend it's impossible, without evidence, and without personal experience.
Personally, I think corsetting is stupid and dangerous bc there're a bunch of things in the belly (liver, spleen, kidneys, intestines...) but the ribcage is mostly lungs, and lungs are spongy, so why not try the same thing there?
+
It's supported by a lot of evidence from our ftm brothers: check the ftm sub using keywords like wrapped/deformed/distorted ribs, misshaped ribcage etc, you will find many testimonies explaining how their chest now looks "sunked in". It's hard to believe everyone is lying (and what would be the reason? to prevent ppl from binding???):
After reading all that, I based my whole idea on copying what caused the described results: binding without any break 24/7, including during sleep, with only short breaks for bath or shower, double binding if necessary, binding until it's painful, etc -- only we'll do that at a different place, bc we want to achieve a different shape.
+
This is akin to the corset diet, advertised by Kim K and others, which consists of wearing a corset all day even when sleeping so as to achieve an hour-glass figure - IDGAF about the waist part, but this is basically the principle: breaking every rule in the book about ftm safe binding to get the desired side effects!
+
BTW, from the "diet" part, expect some weight loss bc it will compress your stomach and make you feel super full even when barely eating anything, so try to eat caloric food if like me you don't want that. And be super careful if you've had an history of ED!
+
How does it work
+
The ribs are attached to the spine in the back and the sternum in the front. When you breathe, your chest cavity expand due to the ribs slightly going up, like the handle of a bucket: they raise in the (X,Z) aka sagittal plane
+
If you did read the links, you'll have noticed most people reported the lower ribs flared out (ex: https://np.reddit.com/r/ftm/comments/a9aikb/yup_my_ribs_are_mildly_deformed_this_is_great/ ), as binding applies an uneven force, with more strength applied to the upper ribs bc of the breast volume. This is because the ribcage is like a rectangle : if you compress the top, the bottom will flare out. So the idea is to do the exact opposite by compressing the bottom part!
+
Quite obv, I didn't my boobs lol. Well, I have to say I tried just to get a feeling of what it does, and damn that shit hurts!
+
Afterwards, I binded the lower ribs, below the boobs. It hurts very differently. The ribs go to a cartilage in the middle, that's flexible: this is how you can expand your chest if you take a deep breath. Binding the lower ribs is just trying the cartilage flexibility in the other direction! Then what if you did that hard enough and long enough to alter the natural shape, like lots of people have reported?
You don't need no fancy binder: just go to amazon and look for a 20-30 inches rib binder with velcro. This XS size is because you'll want to apply a lot of strength there.
+
There're basically 2 version: the male (rectangle) and the female (tapered out for the boobs). Get both, but odds are you'll prefer the male version, as the tapering is done by sewing and the fold will go into your skin and itch.
+
Take your measurements before, expire all the air in your lungs, and apply the binder with the goal of removing at least 2 inches in diameter. Measure again: if you didn't achieve that, try again. If needed, do a double binding: apply the other binder on top.
+
After its done, congrats - you don't need to do nothing else. Just wait a few week lol. Try to sleep on your back, not on your side, to avoid uneven force causing a uneven rib cage (ex: more shrunk on the left that on the right if you sleep on your left side due to the body weight)
+
If it didn't, double binding is more painful but can help. Don't double bind at night, as you want to be aware in case a sudden major pain suggest you should go back to single binding.
+
Practical results
+
After a few week of binding 24/7, I have achieved about 2.5 inches of reduction at the underburst (29.5') , that seem to persist when the rib binder is removed: I've tried up to 1 hour taking a long bath, the max "return to before size" I've noticed is 1 inch (30.5') and more often 0.5 inches. Still, I'll try to do a full 6 month before taking a longer stop, as the results should be cumulative.
+
Even more interesting, the sub cut fat under the ribs seems to have moved down. I had no idea it was even possible! But it's now at the level of my navel. I'll try to push it down further for some booty and hips lol, by using the 2nd binder: I apply the other binder on top, just a bit lower to go slightly over the naked skin of the waist. This is done to cause a strength gradient that will push out fat lower.
+
Based on all my readings from the ftm sub and other sources, proper results will require binding like that between 6 months to 2 years top. However, the results are immediate, and tangible: you get a nice hourglass shape with no investment except $10 for a "bruised rib binder" off amazon. Hopefully, given enough time, these results will be definitive too.
+
Concusion
+
The results are especially especially cool considering there's no surgery on the market to do that: removing floating ribs doesn't change the ribcage diameter!
+
However, it may be dangerous. It may not work on you. I can't say how well it may work (or not) for old ppl who are totally ossified.
+
All I can say it works for me.
+
But I believe these preliminary results are worth sharing. Feel free to share this post wherever.
+
+
+
Comments
+
+
+
+ u/darthemofan ā¢ 6 points
+
+
+
update 3 years later: about 29.5 inches stable after about a year of doing nothing.
+
so Ive resumed the experiment: I'm now trying again with a longer corset to also try to improve the waist and see if I can go to below 29 underbust
+
+
+
+
+
+ u/tsukai1 ā¢ 1 points
+
+
+
Thanks for doing this. Iāve been considering doing this myself but havenāt been able to find anyone posting results after they stopped for a while.
+
+
+
+
+
+
+
+ u/[deleted] ā¢ 3 points
+
+
+
Since you posted your measurements, what are your weight and height? It's hard to interpret without those.
+
Plus, isn't 32 inches about the female average? this study found an average of 81cm.
+
+
+
+
+
+ u/converter-bot ā¢ 1 points
+
+
+
32 inches is 81.28 cm
+
+
+
+
+
+
+ u/darthemofan ā¢ 1 points
+
+
+
+
what are your weight and height?
+
+
I'm a little over 5.6 in height, and 140 lbs in weight
+
+
Plus, isn't 32 inches about the female average?
+
+
I literally have no idea. I'm just looking at improving my waist/hip ratio because I got no hip growth, just some fat.
+
+
+
+
+
+ u/[deleted] ā¢ 2 points
+
+
+
I feel like I have the same thing as you, and emrata. The entire body has feminine proportions, except the hips which fail to be large. I feel like the way to getting an hourglass figure for the vast majority of women is to gain a bit of weight actually. That and squats.
+
+
+
+
+
+ u/darthemofan ā¢ 1 points
+
+
+
yeah the hips suck :(
+
squats IDK, I will try, in the meantime I'll experiment with this for at least 6 month and see if it sticks bc it sure makes my proportions great!
+
at at $10 (well $20 bc I got 2 lol) it aint too expansive
+
+
+
+
+
+
+
+
+
+ u/[deleted] ā¢ 2 points
+
+
+
what about with a corset. Like rigid one, like the ones from the 19th century or so
+
+
+
+
+
+ u/darthemofan ā¢ 1 points
+
+
+
that's like super expansive, and it would touch the waist.
+
I'm not comfortable doing that, and my budget was like $50 for this experiment.
+
ofc if you want to financially support Darth Dangerous Experiments, I'm all ears lol
+
+
+
+
+
+ u/[deleted] ā¢ 2 points
+
+
+
Not one of those 200Ā£ corsets like, one that you can buy on amazon too for 50$ and in a conical shaoe, which squeezes the ribs. I really need all the money I can get so I was just asking in case you knew š
+
+
+
+
+
+ u/darthemofan ā¢ 1 points
+
+
+
tbh, the waist is rarely the problem, and I find the super slim waist like Cathy Jung pics freaskish and ugly. it's not proportionate. personally, I'm 26' at the waist, it's not fab, but okish as I'm on the tallish side, a little over 5.6
+
what worries me more is my chest and shoulders. one of them is fucked up following me falling drunk during a party. I was planning to get sugery then fucking covid happen
+
this is was an experiment to see if it could make waiting easier. one totally unrelated good thing (not reported here bc it's not relevant to anyone but me) is that my shoulder is hurting less, after initially hurting more for the first few days of binding.
+
I litterally have no idea why, but I'll take it :)
+
+
+
+
+
+ u/[deleted] ā¢ 2 points
+
+
+
how. I'm a little over 5.6 and have a 27', fuck my life .Are you talking about shoulder narrowing surgery? That shit is expensive
+
+
+
+
+
+ u/darthemofan ā¢ 1 points
+
+
+
+
I'm a little over 5.6 and have a 27', fuck my life
+
+
26' vs 27' isn't a big difference. our proportions are about the same. I'm sure you look great!
+
+
Are you talking about shoulder narrowing surgery? That shit is expensive
+
+
yeah but I was looking at non US surgeon. in normal countries with normal prices, it should cost at most 3 to 4 grands all included.
+
everything healthcare related has crazy inflated prices in the US.
+
+
+
+
+
+
+
+
+
+
+
+ u/darthemofan ā¢ 1 points
+
+
+
update 3 weeks later: I now get 29 inches underbust with the binder, 30.0 without
+
it's stable for 4h (the longest I've tried), so apparently the results get better with time!
+
the overbust seems stable at 34 inches (I didn't measure it before the experiment, oops)
+
Update 7 month later after not wearing the binder for like a full month (I got sick) and only resuming for like 1 week:
+
Weight 144 lbs
+
Overbust 35
+
Underbust 31 without the binder, 30.5 with it. It's dead I can see I need a new one :)
+
+
+
+
+
+ u/ani_3113 ā¢ 2 points
+
+
+
Amazing progress!
+
My binder has arrived. I have only tried it on for fit so far. Damn it's tight! I felt a bit discouraged after that initial test but this update has really got me fired up again!
+
+
+
+
+
+ u/darthemofan ā¢ 1 points
+
+
+
careful, avoid the breast area, in my experience you still got quite enough grip on the lower ribs. if you got a velcro model, you can adjust the tightness. start with a few hours, then more and more every day.
+
it took me 2 weeks to get use to the double binding for sleeping
+
btw if you try this, don't be like me, plz take your full measurements including upper bust and report on your progress every week :)
+
+
+
+
+
+
+
+ u/darthemofan ā¢ 1 points
+
+
+
update almost 6 weeks later: same results, no further changes. but at palpation, my lower ribs now seem wrapped.
+
it's hard to explain, but there is a given slope but the upper ribs until those that are below the breast, then there is a different slope below. I can't confirm if it's new but I had never noticed before. I noticed because I feared one rib was misaligned/inflammed/broken, but no, it's in line with the other ribs above, just not with the ribs below
+
the separation is midway in the binder, which makes me want to modify the protocol and bind a bit diagonally (higher in the back that in the front to avoid the breasts) but when I tried it slipped. I need some kind of suspenders or something to hold the binder into place.
+
there is some low degree constant pain around my right shoulder. it's hard to pinpoint it. it reminds me of the pain when I cracked a rib after a fall. so I'm super happy about that :) Now if only the left shoulder could hurt too!!!
+
my bf commented on how there seems to be a "line" where the bottom of the binder stops: it's as if the subcut fat was reduced above, and increased below. I'ved tried to complement that with an abdominal binder (bc, why not also get a thin waist!!) but it rolls up, regardless of the brand and fabric. I guess it really needs some kind of boning, but I don't want to spend a fortune on corset, and waist is at best a very secondary objective, so I'll do without
+
+
+
+
+
+
+
+ u/reddened_skies ā¢ 1 points
+
+
+
this is cool! just out of curiosity is there a link where you go into detail about stopping and restarting e?
I have been dropping a lot of weight lately and the bottom of my ribs are now sticking out a bit. I will try this as I think it makes sense and I think it will have desired effect on me. There was however one more thing I was thinking about.
+
As I said, I have been losing weight. I'm currently down to 7% body fat and I think I've reached my goal. I'm now planning on gaining weight. I want to go up to 25%. A common problem when gaining relatively fast is you put most of on your belly. I was thinking though, if you are "binding", That far down I'd say corseting but let's stay on topic. If you were binding tightly, would the fat find it a hard time to grow, would I maybe be able to avoid a couple of lbs that would have otherwise gone to my belly? Food for thought.
+
+
+
+
+
+ u/darthemofan ā¢ 2 points
+
+
+
+
my ribs are now sticking out a bit. I will try this as I think it makes sense and I think it will have desired effect on me.
+
+
please share your preliminary results (measurements before, and after 3 weeks) when you can! start simple then double bind at least in the daytime. at night it can be hard to sleep if you toss and turn like me with double binding
+
+
If you were binding tightly, would the fat find it a hard time to grow, would I maybe be able to avoid a couple of lbs that would have otherwise gone to my belly?
+
+
I think you have a great idea there! If you look at guys wearing high speedos (not sure about the name) instead of briefs , they often have a small line there. obviously the pressure of an elastic band is not enough, but it matches the idea
+
Bc likewise, after fat transfer or lipo, compression garnments are worn - and I remember reading various experience of ppl having fat removed from one point (say belly) only to regain it homogeneously on the parts that didn't have lipo (butt, chicken wings, boobs). so I think your theory is right as everything seems to match!
+
To be sure, I just made some hip measurements, and I confirm a gain there, while my weight is stable!
+
+
Food for thought
+
+
Not just that, it is a very interesting extension to also help ppl pre transition: they could lose weight, then do lower binding when starting hrt !!
+
ofc it should be confirmed before being suggested, but I really think you're on to something. plz plz plz share you results when you try!
+
+
+
+
+
+ u/ani_3113 ā¢ 1 points
+
+
+
I am going ahead with this idea and I will keep you posted. I will probably start this next week or so.
+
I think the logic makes sense. It should at the very least help. This might be an idea for other people to try as well when weight cycling.
+
I will post updates!
+
+
+
+
+
+
+
+
+ u/Dry-Elevator9217 ā¢ 1 points
+
+
+
Dear author, how do you think is it safe to do this if you haveĀ hyperkyphosis?Ā
The efficacy of topical aminophylline in local fat reduction: A systematic review
+
Abstract
+
Background and aims
+
Some studies have reported that the topical forms with aminophylline as the active ingredient appear to be relatively effective on local fat burning while having no/minimal side effects. This systematic review accumulates all of the data on the local fat-burning potency of aminophylline topical formulation.
Methods
+
Documents were retrieved from PubMed, Web of Science, and Scopus databases until Aug 2022. Data were extracted from clinical trials reporting the reduction in thigh or waist circumference as a result of using topical forms containing aminophylline. Screening of included studies was performed independently by two authors and the quality assessment of included studies was performed based on the Cochrane Collaborationās approach.
Results
+
Of the 802 initial studies, 5 studies were included in the systematic review. Several concentrations of aminophylline were used in different studies. Most studies administred the topical formulation on participantsā one thigh, and the other thigh was considered to be the control for comparing the fat reduction amount. Except for one study, all other studies reported that all participants lost more fat on the treated area than the control groups. The amount of fat reduction differed in studies regarding their different aminophylline concentrations and administration routines. In the case of side effects, except for some studies reporting skin rashes, other studies reported no significant side effects at all.
Conclusions
+
Aminophylline topical formulation offers a safe, effective, and much less invasive alternative to cosmetic surgery for localized fat reduction. It seems that the 0.5% concentration, administered five times a week for five weeks is the most potent concentration. However, more high-quality clinical trials are needed to verify this conclusion.
Obesity is a multifactorial chronic and progressive disease of excess adipose tissue that can occur at any age (1). According to reports (2), 46% of adults aged ā„20 are overweight or obese worldwide. Moreover, United States (US) has the highest obesity rate, with a prevalence of 34% in adults (3). Studies have also predicted that nearly 1.92 billion people worldwide will be obese or overweight by 2030 (2). On top of the physical health risks associated with obesity, negative psychological consequences are also inevitable. Depression (4ā6), body image dissatisfaction (7), and stress (7ā9) are all examples of this regard that can reduce oneās quality of life both directly and indirectly.
+
Regarding obesity management strategies, behavioral modification is one of the main approaches. However, depressed mood and anxiety reduce obese peopleās functioning and their adherence to lifestyle changes (8). Medical interventions, on the other hand, are becoming more popular, and the obesity control guidelines strongly recommend medical interventions for overweight patients (10). In the case of these interventions, the most common approaches are oral/injectable anti-obesity medications (11ā13) and bariatric surgeries (14). However, there are some drawbacks to these medical interventions too. The most significant disadvantages of oral anti-obesity agents (i.e., phentermine/topiramate, naltrexone/bupropion, and orlistat) are their systematic side effects, such as neuro-psychiatric, fetal, and cardiovascular side effects (11ā13). Furthermore, it has been reported that the degree of weight loss provided by anti-obesity medications does not typically provide the type of cosmetic benefit that many patients seek (11, 12). In the case of injectable medications (i.e., liraglutide) and bariatric surgeries, their main disadvantage is their aggressive method of administration and their high costs (12, 14, 15). As a result, the most appropriate drug is one that is more effective, has fewer side effects, is less expensive, and is administered in a non-aggressive manner.
+
Topical formulations, on the other hand, are non-aggressive methods of drug administration and have significantly fewer side effects due to their low systematic absorbance. Regarding efficacy, several attempts have been made to develop a topical formulation for local fat loss (16ā21). Among all, some studies have reported that the topical forms with aminophylline as the active ingredient appear to be relatively effective on local fat burning while having no/minimal side effects.
+
Therefore, the goal of this study was to accumulate all of the data on the local fat-burning potency of aminophylline topical formulation in order to get one step closer to developing topical and effective fat burner agents.
Methods
+
Prior to the start of the study, a detailed research protocol was prepared and registered in the international prospective register of systematic reviews (PROSPERO) with the CRD42022353578 ID, which was then followed throughout the process. The 27-item PRISMA (preferred reporting items for systematic reviews and meta-analyses) statement was used as the reporting model for this systematic review to ensure inclusiveness (22). Furthermore, the 12-item āPRISMA for abstractā extension was used to write the abstract (23).
+
Search strategy
+
A complete search strategy used for each database is reported in
+Supplementary TableĀ 1
+. Two researchers independently searched until Aug 2022 for relevant articles published (with no restriction of publication year) in the following data sources: PubMed, web of science, and Scopus using the following search terms: āAminophyllineā OR āTheophylline ethylenediamineā OR āTheophylline-ethylenediamineā AND āTopicalā OR āTopical administrationā OR āCreamā OR āLotionā OR āLocalā OR āSubcutaneousā OR āFatā OR āFat burnā OR āFat burnerā OR āFat burningā OR āFat reductionā OR āFat reducerā OR āFat lossā OR āLipolysisā OR āContouringā OR āBody contouringā OR āWaistā OR āThighā OR āSkinā OR āCircumferenceā OR āRegionalā OR āCelluliteā OR āAdipose tissueā OR āAdiposityā OR āObesityā OR āMesotherapyā OR āCosmeticā. Studies with any search terms in their title or abstract were found, and their abstracts were pooled and imported into Endnote Reference Manager. After excluding duplicate studies and completing screening stages, the research team decided which studies will finally be chosen.
Eligibility criteria and study selection
+
Obesity and cellulite were designated as the studyās exposures of interest. The intervention was defined as topical aminophylline application, and the local fat reduction in the studied body area, as our primary outcome of interest, was compared between exposed and unexposed populations. After excluding duplicate studies, two independent researchers performed the first screening stage, examining the remaining articles in accordance with the studyās stated objectives. Reviews, animal studies, experimental studies, clinical trials, and editorial or other types of letters were excluded at this stage.
+
Through the second screening stage, clinical trials were included if:
+
+
Aminophylline was used in topical form (cream, lotion, ointment, and gel) alone or in combination with other ingredients.
+
Desired information on the participants was provided.
+
Results were reported as the amount of subcutaneous fat reduced.
+
+
Studies got excluded if:
+
Each researcher reported the studies they had picked after the second screening stage, and the team decided which studies would ultimately be selected for data synthesis. Disagreements were settled, if necessary, by a discussion with a third research team member.
Data extraction
+
Data from papers were individually gathered by two reviewers and entered into Microsoft Excel.
Study characteristics: study location, number of participants, participantsā characteristics, pharmaceutical form of aminophylline, other ingredients of topical formulation (if applicable), and body area(s) studied.
+
Critical data: Topical formulation and concentration of active pharmaceuticals, administration routine, other interventions (if applicable), adverse effects (if reported), and final results in as much detail as possible (mean Ā± SD or median Ā± SE).
+
Risk of bias assessment
+
Using the Cochrane Collaborationās approach (24), two reviewers independently categorized studies as having a low, high, or uncertain risk of bias in various domains. Then, if necessary, disagreements were discussed with a third researcher on the research team in order to be resolved.
+
The risk assessment method developed by Cochrane Collaboration evaluates the probability of bias in six areas for each study. Areas are āSelection biasā, āPerformance biasā, āDetection biasā, āAttrition bias ā, āReporting biasā, and āOther biasā. The āselection biasā section checks whether the study clearly describes the allocation sequence generation process so that it can be determined whether or not it should result in comparable groupings. Furthermore, it also verifies whether the study has indicated if intervention allocations could have been anticipated before or during enrollment by providing enough information about the technique employed to disguise the allocation sequence. The āPerformance biasā section monitors if the study describes the procedures taken, if any, to prevent trial participantsā intervention status from being known to researchers. The āDetection biasā section ensures if the study describes all procedures taken, if any, to prevent participantsā particular interventions from being known during outcome evaluation. The āAttrition biasā determines whether the study describes how comprehensive the outcome data is for each primary outcome, taking attrition and analytical exclusions into account. And finally, the āReporting biasā section examines if the study describes the methodology used to analyze selective outcome reporting.
Results
+
Study selection
+
+
+FigureĀ 1
+ displays a flowchart of the study selection processā summary. Using the aforementioned search protocol, 802 articles were initially found, including 299 from PubMed, 321 from Scopus, and 182 from Web of Science. The total number of 399 items made it to the first stage of screening after 403 duplicates were eliminated. Then, 382 articles were excluded as a consequence of the first stepās title and abstract screening because they were either unrelated to the issue or did not include the information that was sought. Twelve studies were eliminated from the 17 remaining papers that underwent full-text screening because there was insufficient information presented on the relationship between the topical use of aminophylline and local fat reduction. Finally, data from five papers (17, 18, 25ā27) were used after they satisfied all inclusion criteria.
+
FigureĀ 1.
+
+
A summary of the study screening process.
Basic characteristics of the selected studies
+
+
+TableĀ 1
+ shows the basic characteristics of the five studies that were finally included. All studies except one that was carried out in England (25), were done in the US. Six sub-trials were included in one of the studies (18), of which five were utilized in this study. That one study was dropped because it utilized injection administration. In general, sample sizes in studies were small but varied, ranging from five to 25 participants and totaling 117 people, which were mostly women. The majority of the research was done on participants who were obese, thought they were obese, or thought their thighs were unattractively fat. With the exception of two studies that created lotion (27) and gel (17) forms, all other studies formulated creams and ointments. Three of the trials added additional components to the formulation. Forskolin, yohimbine, caffeine, L-carnitine, and gotu kola (Centella asiatica) were added in two of the studies to boost the fat-burning impact, while glycolic acid was added in the other to increase cream penetration into the skin. Three trials used the AquaphorĀ® base for formulating ointment. Regarding the body area(s) tested, all studies tested on the thighs, except for one study that tested the topical formulation on the waist (26). Among all, two studies examined the buttocks as well (17, 25).
+
TableĀ 1.
+
Basic characteristics of clinical trials evaluating the effect of topical aminophylline in local fat reduction.
ā¢ All participants felt that their thighs were undesirably fat. ā¢ Some women wanted to lose weight while others were satisfied with their present weight.
ā¢ All participants felt that their thighs were undesirably fat. ā¢ Some women wanted to lose weight while others were satisfied with their present weight.
ā¢ All participants were obese and overweight with a BMI greater than 27 kg/m2. ā¢ Participantsā age was between 21 and 65 years. ā¢ Participants had android fat distribution (characterized by a waist to hip ratio >0.80 in women or >1.0 in men).
ā¢ Caffeine, ā¢ Yohimbe ā¢ L-Carnitine ā¢ Gotu kola
+
Thighs
+
+
+
+
Outcomes
+
A detailed summary of studies evaluating the effect of topical aminophylline in local fat reduction is provided in
+TableĀ 2
+. As can be seen, several concentrations of aminophylline were used in different studies. Among all, the highest concentration of aminophylline used was 10%, with the administration of five times a week on participantsā one thigh (18). The other thigh was considered to be the control for comparing the fat reduction amount. Although participants were suggested to stick to a 900 to 1,100 kcal/day diet, they were not suggested to do any exercises. After six weeks, there had been a higher loss in participantsā thigh girth in the treated thigh than in the control thigh, with a mean Ā± SEM difference of 0.77 Ā± 0.66Ā cm for the lower girth and 0.78 Ā± 0.89Ā cm for the upper girth (p < 0.001). Heart rate, blood pressure, and blood chemistry all remained unchanged. Additionally, no theophylline could ever be found in blood samples, and no allergic reactions were documented.
+
TableĀ 2.
+
A summary of studies evaluating the effect of topical aminophylline in local fat reduction.
ā¢ Patients avoided any medications affecting theophylline serum levels.
+
The thigh circumference was decreased an average of 0.5Ā cm, but with no weight reduction.
+
ā¢ Total cholesterol, triglycerides, HDL, and LDL did not show any significant changes after three months. ā¢ Aminophylline serum levels did not raise.
1.2Ć10-5 M forskolin + 2.5Ć10-4 M yohimbine + 1.3Ć10-2 M aminophylline
+
Five times a week for four weeks
+
ā¢ 600 kcal/day diet ā¢ Patients were encouraged to follow a walking program ā¢ To increase transcutaneous absorption, the thighs were wrapped in warm 600 to 900 mOsm/L magnesium sulphate solutions for 30 minutes before each of the ointment applications. ā¢ An occlusive plastic wrap was placed over the area to which the ointment was applied throughout the 4-week study period.
+
All participants lost more girth on the treated thigh than the control thigh with a mean Ā± SEM difference of 2.03 Ā± 1.36Ā cm (p<0.05)
+
ā¢ One of the ladies who participated in this study, which was carried out in the summer, experienced a heat rash under the occlusive plastic wrap on both legs that went away after the plastic wrap was removed.
ā¢ 800 kcal/day diet ā¢ Patients were encouraged to follow a walking program ā¢ To increase transcutaneous absorption, the thighs were wrapped in warm 600 to 900 mOsm/L magnesium sulphate solutions for 30 minutes before each of the ointment applications.
+
All participants lost more girth on the treated thigh than the control thigh with a mean Ā± SEM difference of 1.5 Ā± 0.77Ā cm (p<0.02)
+
ā¢ There were no rashes or other adverse events. ā¢ There were no changes in blood pressure or pulse
ā¢ 900 to 1,100 kcal/day diet ā¢ No specific exercise
+
Thigh girth loss was greater in the treated than in the control thigh at the end of the study with a mean Ā± SEM difference of 0.77 Ā± 0.66Ā cm for the lower girth and 0.78 Ā± 0.89Ā cm for the upper girth (p<0.001)
+
ā¢ No significant changes were seen in the chemistry results. ā¢ No theophylline could be detected at any time point. ā¢ Patch testing showed no allergy. ā¢ There were no significant changes in pulse rate or blood pressure.
Participants lost more girth from the treated than from the control thigh with a mean Ā± SEM difference of 1.21 Ā± 0.31Ā cm (p<0.01)
+
ā¢ There was no skin irritation with patch testing. ā¢ Three weeks after the start of the study, one woman developed a rash on the leg being treated with active cream. The cream was stopped and the rash resolved ā¢ Theophylline levels were undetectable
All 12 participants lost more girth on the treated thigh than the control thigh at 5 weeks of treatment with a mean Ā± SEM difference of 3.08 Ā± 0.27Ā cm (p<0.0011)
+
ā¢ The chemistry panel showed significant decreases in ALT, LDH, globulin and creatinine, but these were felt to be clinically insignificant since the changes were within the normal range for the test. ā¢ There were no rashes. ā¢ Patch testing was negative. ā¢ Theophylline levels were below the detectable threshold.
ā¢ 1200 kcal/day diet ā¢ Patients were encouraged to follow a walking program
+
The reduction in waist circumference was 11 Ā± 1.0Ā cm in the aminophylline cream group and 5.0 Ā± 0.6Ā cm in the control group (p < 0.001).
+
ā¢ All monthly aminophylline levels were undetectable. ā¢ There were no adverse events ā¢ There were no allergic reactions to the cream. ā¢ Blood pressure and pulse remained in the normal range throughout the study.
Aminophylline, caffeine, yohimbe, lācarnitine, and gotu kola
+
Twice a day for four weeks
+
ā¢ 1520 Ā± 321 kcal/day diet ā¢ Patients were encouraged to follow a walking program
+
Reduction in thigh circumference was 1.2Ā cm compared to 0.8Ā cm in control groups.
+
ā
+
+
+
+
In the case of 2% aminophylline concentration, there were three experiments. None of the three studiesā participants maintained a regular diet or exercise routine. In the first two studies (17, 25), using twice-daily treatment, one of them indicated a mean 0.5Ā cm reduction in thigh fat after 12 weeks, and the other found no significant difference in the fat reduction after 12 weeks. The third study (18), applying the cream five times a week, reported that participants lost more girth from the treated than from the control thigh with a mean Ā± SEM difference of 1.21 Ā± 0.31Ā cm (p < 0.01) after six weeks. While one of the studies reported no side effects at all, two other studies reported skin rashes in nine out of 35, and one out of 11 participants.
+
Regarding 0.5% aminophylline concentration, there existed two experiments. In one of them (18), participants applied the topical formulation five times per week for five weeks without engaging in any physical activity or dietary changes. As a result, the treated thigh lost more circumference than the control thigh, with a mean Ā± SEM difference of 3.08 Ā± 0.27Ā cm (p < 0.001) in all 12 participants. Neither any dermatologic rashes nor any theophylline serum levels were detected. Moreover, although alanine transaminase (ALT), lactate dehydrogenase (LDH), globulin, and creatinine levels in the chemistry panel all significantly decreased, the changes were deemed to be clinically unimportant because they were within the testās normal range. In the second research on the 5% aminophylline concentration (26), the topical formulation was administered twice daily on the participantsā waist, the subjects consumed 1200Ā kcal per day, and walking programs were suggested. After 12 weeks, the mean reduction in waist circumference was 11 Ā± 1.0Ā cm in the aminophylline cream group and 5.0 Ā± 0.6Ā cm in the control group (p < 0.001). Blood pressure and heart rate remained unchanged throughout the study, no allergic reactions were reported, and all monthly aminophylline levels were undetectable.
+
There existed one study using 1.3Ć10-2 M aminophylline concentration in the topical form five times a week (18). Participants were encouraged to stick to a 800 kcal/day diet and to follow a walking program. For 30 minutes before each application of ointment, the thighs were wrapped in heated 600 to 900 mOsm/L magnesium sulphate solutions to increase absorption. After four weeks, on the treated thigh, more girth was decreased than on the untreated thigh with a mean Ā± SEM difference of 1.5 Ā± 0.77Ā cm (p <0.02). Regarding side effects, no rashes and no changes in blood pressure and heart rate were reported.
+
Finally, two studies added other active ingredients to their topical formulation. In the first one (18), the formulation was 1.2Ć10-5 M forskolin plus 2.5Ć10-4 M yohimbine plus 1.3Ć10-2 M aminophylline and was administered five times a week. Participants were encouraged to stick to a 600 kcal/day diet and follow a walking program. To increase transcutaneous absorption, the thighs were wrapped in warm 600 to 900 mOsm/L magnesium sulphate solutions for 30 minutes before each of the ointment applications. Moreover, the region to which the ointment was applied was covered with an occlusive plastic wrap. After four weeks, the treated thigh of each subject shrunk more than the control thigh with a mean Ā± SEM difference of 2.03 Ā± 1.36Ā cm (p <0.05). In the case of side effects, one of the women who took part in this trial, which was conducted in the summer, developed a heat rash on both legs under the occlusive plastic wrap, which disappeared once the plastic wrap was taken off. Another study (27), which supplemented the topical formulation with other active components, combined the effects of aminophylline, caffeine, yohimbe, l-carnitine, and gotu kola to reduce localized fat. The formulation was used twice a day along with a 1520 Ā± 321 kcal/day diet and walking program. After four weeks, the reduction in thigh circumference was 1.2Ā cm compared to 0.8Ā cm in the control groups.
Risk of bias assessment
+
+
+Supplementary TableĀ 2
+ shows the results of Cochrane Collaborationās tool for assessing the risk of bias in the final retrieved studies. As can be observed, in the āRandom sequence generationā area all research had an uncertain risk of bias, except for one study (27) that had a low risk of bias. The results in the āAllocation concealmentā domain were exactly the same. In the āBlinding of participants and personnelā area, all research had a low risk of bias, except for one study that had a high risk of bias (17). Results in the āBlinding of outcome assessmentā section were varied, with two, one, and two studies having high, unclear, and low risk of bias, respectively. Regarding the āIncomplete outcome dataā domain, studies had one unclear, three lows, and one high risk of bias. In the case of the āSelective reportingā area, all studies had a low risk of bias. Finally, no studies had other types of biases.
Discussion
+
This research established the possibility for topical formulations with aminophylline as their active component to be employed as local fat burners. Furthermore, even though it was demonstrated that these topical treatments alone can reduce subcutaneous fat, it seems that adding even a slight exercise and diet may increase their effectiveness.
+
Aminophylline is a bronchodilator agent that is FDA-approved for managing acute asthma and is available in the form of oral capsules, oral tablets, and intravenous solutions. Although it is not FDA-approved for local fat reduction, some aminophylline-containing creams are currently available in the store and are advertised as cellulite removers. Whether or not they are obese, many women worry about how their thighs, buttocks, waist, and double chin look. Women who turn to surgical treatments as a kind of therapy because they are so upset with the way their body fat looks benefit from topical forms of fat burning the most. Topical lipolysis is less dangerous, with avoiding the associated dangers of surgery, such as scarring and infection hazards, as well as anesthesia risks. Moreover, most of the ladies who participated in trials evaluating the potency of topical aminophylline in local fat reduction reported having a better sense of how their body looked, which may have actually enhanced how they felt about themselves. However, although the topical formulation of aminophylline seemed to be helpful in reducing localized fat, trials that did not take into account diets and exercise routines for participants did not report many cases of weight loss. Therefore, the difference in subcutaneous fat and lack of difference in weight reduction between the two groups point to a superficial alteration in fat distribution.
+
Side effects
+
Regarding side effects, all trials that tracked participant blood chemistry, blood pressure, blood levels of aminophylline and theophylline, and pulse rate found no significant changes, therefore it appears that this formulation is safe in terms of adverse effects. The only unfavorable consequence that was noted occasionally was skin rashes. Regarding why rashes happened, some studies suggested possible mechanisms. It was recognized that aminophylline, which is made up of two theophylline molecules linked by an ethylenediamine molecule, is a skin irritant (26). In studies using a simple base cream, it was reported that a chemical reaction with aminophylline causes a common cream base to become yellow. This yellow cream fails to work and gave some test subjects rashes (26). As a result, it was proven that utilizing a specially created cream base that stabilizes the aminophylline decreases skin rashes in addition to assisting in adjusting its skin penetration.
Possible mechanism of action
+
Xanthenes are thought to increase collagen production, lipolysis, microcirculation, and thermogenesis along with decreasing adipogenesis (28ā31). In the case of their lipolytic actions, publications have shown that beta-adrenergic stimulation directly increases the cyclic adenosine monophosphate (cAMP) concentrations of fat cells in adipocytes, which is believed to be the underlying mechanism (28, 30, 32, 33). The increased cAMP levels cause protein kinase A to phosphorylate the activating hormone-sensitive lipase (HSL). Now, triglycerides are hydrolyzed by phosphorylated HSL into free fatty acids, glycerol, diglycerides, and monoglycerides (34). Parallelly, since xanthines are thought to inhibit phosphodiesterase (PDE), an enzyme involved in the degradation of cAMP, as well, the inhibition of PDE further raises cAMP activity. Therefore, the researchers believe that by applying aminophylline topically to suppress PDE, local cAMP concentrations and local lipolysis would both rise (28, 30, 35ā37).
Strength and limitations
+
This study was one of the first systematic reviews about local fat burning by topical formulations. To ensure comprehensiveness, we reported the outcomes of studies using various aminophylline concentrations in their topical formulations, as well as formulations using substances other than aminophylline alone. However, there are some limitations to this study. First of all, despite a comprehensive search strategy, there were few recent research on our subject, and the sources used for this study are relatively old. One possible reason for this oldness may be that most of the studies concentrate on the intravenous administration of aminophylline, and the topical use is not well known. Second, there isnāt enough information accessible for each concentration to allow for useful comparison because there arenāt many references, and each reference employed different concentrations. Third, some references exhibited a high risk of bias in particular areas after utilizing the Cochrane Collaborationās methodology to assess the risk of bias.
Conclusion
+
Aminophylline topical formulation offers a safe, effective, and much less invasive alternative to cosmetic surgery for the localized reduction of fat. Conducting further trials to compare the efficacy of different concentration of aminophylline is suggested for future works, as well as evaluating the efficacy of other xanthines in local fat burning.
Data availability statement
+
The original contributions presented in the study are included in the article/
+Supplementary Material
+. Further inquiries can be directed to the corresponding author.
Author contributions
+
RA and AH: Writing the manuscript, Collecting the data. ED and MQ: Designing the study, Checking and revising, Supervision. All authors contributed to the article and approved the submitted version.
Funding Statement
+
The present manuscript was supported by Alborz University of Medical Sciences (ID: 103-5410).
Conflict of interest
+
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisherās note
+
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
+
+
+1.
+Jastreboff AM, Kotz CM, Kahan S, Kelly AS, Heymsfield SB. Obesity as a disease: The obesity society 2018 position statement. Obesity (2019) 27(1):7ā95. doi:Ā 10.1002/oby.22378
+ [DOI] [PubMed] [Google Scholar]
+
+2.
+Orukwowu U. Epidemiology of adult obesity, measurements, global prevalence and risk factors. IPS Intelligentsia Multidiscip J (2022) 1(1):1ā6. doi:Ā 10.54117/iimj.v1i1.1
+ [DOI] [Google Scholar]
+
+3.
+Ward ZJ, Long MW, Resch SC, Gortmaker SL, Cradock AL, Giles C, et al. Redrawing the US obesity landscape: Bias- corrected estimates of state-specific adult obesity prevalence. PloS One (2016) 11(3):1ā135. doi:Ā 10.1371/journal.pone.0150735
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+
+4.
+Patsalos O, Keeler J, Schmidt U, Penninx BWJH, Young AH, Himmerich H. Diet, obesity, and depression: A systematic review. J Personalized Med (2021) 11(3):1ā195. doi:Ā 10.3390/jpm11030176
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+
+5.
+Pistis G, Milaneschi Y, Vandeleur CL, Lasserre AM, Penninx BWJH, Lamers F, et al. Obesity and atypical depression symptoms: Findings from mendelian randomization in two European cohorts. Trans Psychiatry (2021) 11(1). doi:Ā 10.1038/s41398-021-01236-7
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+
+6.
+Frank P, Jokela M, Batty GD, Lassale C, Steptoe A, KivimƤki M. Overweight, obesity, and individual symptoms of depression: A multicohort study with replication in UK biobank. Brain Behavior Immun (2022) 105:192ā200. doi:Ā 10.1016/j.bbi.2022.07.009
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+
+7.
+Chu DT, Nguyet NTM, Nga VuT, Lien NVuT, Vo DD, Lien N, et al. An update on obesity: Mental consequences and psychological interventions. Diabetes Metab Syndrome: Clin Res Rev (2019) 13(1):155ā60. doi:Ā 10.1016/j.dsx.2018.07.015
+ [DOI] [PubMed] [Google Scholar]
+
+8.
+Finer N. Medical consequences of obesity. Med (United Kingdom) (2015) 43(2):88ā93. doi:Ā 10.1016/j.mpmed.2014.11.003
+ [DOI] [Google Scholar]
+10.
+Tak YJ, Lee SY. Long-term efficacy and safety of anti-obesity treatment: Where do we stand? Curr Obes Rep (2021) 10(1):14ā30. doi:Ā 10.1007/s13679-020-00422-w
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+
+11.
+Kang JG, Park CY. Anti-obesity drugs: A review about their effects and safety. Diabetes Metab J (2012) 36(1):13ā255. doi:Ā 10.4093/dmj.2012.36.1.13
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+
+12.
+Bessesen DH, Van Gaal LF. Progress and challenges in anti-obesity pharmacotherapy. Lancet Diabetes Endocrinol (2018) 6(3):237ā48. doi:Ā 10.1016/S2213-8587(17)30236-X
+ [DOI] [PubMed] [Google Scholar]
+
+13.
+Singh AK, Singh R. Pharmacotherapy in obesity: A systematic review and meta-analysis of randomized controlled trials of anti-obesity drugs. Expert Rev Clin Pharmacol (2020) 13(1):53ā64. doi:Ā 10.1080/17512433.2020.1698291
+ [DOI] [PubMed] [Google Scholar]
+
+14.
+Arterburn DE, Telem DA, Kushner RF, Courcoulas AP. Benefits and risks of bariatric surgery in adults: A review. JAMA - J Am Med Assoc (2020) 324(9):879ā8875. doi:Ā 10.1001/jama.2020.12567
+ [DOI] [PubMed] [Google Scholar]
+
+15.
+Lin CH, Shao L, Zhang Y, Tu YJ, Zhang Y, Tomlinson B, et al. An evaluation of liraglutide including its efficacy and safety for the treatment of obesity. Expert Opin Pharmacother. (2020) 21(3):275ā2855. doi:Ā 10.1080/14656566.2019.1695779
+ [DOI] [PubMed] [Google Scholar]
+
+16.
+Greenway FL, Bray GA. Regional fat loss from the thigh in obese women after adrenergic modulation. Clin Ther (1987) 9(6):663ā9. [PubMed] [Google Scholar]
+
+17.
+Artz JS, Dinner MI. Treatment of cellulite deformities of the thighs with topical aminophylline gel. Plast Surg (1995) 3(4). doi:Ā 10.4172/plastic-surgery.1000129
+ [DOI] [Google Scholar]
+
+18.
+Greenway FL, Bray GA, Heber D. Obesity research.
+Torrance, CA: Harbor-UCLA Medical Center, Department of Medicine, Division of Endocrinology, UCLA School of Medicine: (1995). 3:S561ā8. doi:Ā 10.1002/j.1550-8528.1995.tb00228.x
+ [DOI] [Google Scholar]
+20.
+Armanini D, Nacamulli D, Francini-Pesenti F, Battagin G, Ragazzi E, Fiore C. Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application. Steroids (2005) 70(8):538ā5425. doi:Ā 10.1016/j.steroids.2005.01.007
+ [DOI] [PubMed] [Google Scholar]
+
+21.
+Lee G-R, Shin MK, Yoon D-J, Kim A-R, Yu R, Park N-H, et al. Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice. Obesity (2013) 21(1):115ā22. doi:Ā 10.1002/oby.20246
+ [DOI] [PubMed] [Google Scholar]
+
+22.
+Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. BMJ (2009) 339(7716):332ā6. doi:Ā 10.1136/bmj.b2535
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+
+23.
+Beller EM, Glasziou PP, Altman DG, Hopewell S, Bastian H, Chalmers I, et al. PRISMA for abstracts: Reporting systematic reviews in journal and conference abstracts. PloS Med (2013) 10(4). doi:Ā 10.1371/journal.pmed.1001419
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+
+24.
+Higgins JPT, Altman DG, GĆøtzsche PC, JĆ¼ni P, Moher D, Oxman AD, et al. The cochrane collaborationās tool for assessing risk of bias in randomised trials. BMJ (Online) (2011) 343(7829):1ā9. doi:Ā 10.1136/bmj.d5928
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+
+25.
+Collis N, Elliot LA, Sharpe C, Sharpe DT. Cellulite treatment: A myth or reality: A prospective randomized, controlled trial of two therapies, endermologie and aminophylline cream. Plast Reconstructive Surg. (1999) 104:1110ā4. doi:Ā 10.1097/00006534-199909020-00037
+ [DOI] [PubMed] [Google Scholar]
+
+26.
+Caruso MK, Pekarovic S, Raum WJ, Greenway F. Topical fat reduction from the waist. Diabetes Obes Metab (2007) 9(3):300ā3. doi:Ā 10.1111/j.1463-1326.2006.00600.x
+ [DOI] [PubMed] [Google Scholar]
+
+27.
+Escalante G, Bryan P, Rodriguez J. Effects of a topical lotion containing aminophylline, caffeine, yohimbe, l-carnitine, and gotu kola on thigh circumference, skinfold thickness, and fat mass in sedentary females. J Cosmetic Dermatol (2019) 18(4):1037ā10435. doi:Ā 10.1111/jocd.12801
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+
+28.
+Article, Review . Cellulite and its treatment. Int J Cosmetic Sci (2006) 28:175ā90. doi:Ā 10.1111/j.1467-2494.2006.00318.x
+ [DOI] [PubMed] [Google Scholar]
+
+29.
+Dulloo AG. The search for compounds that stimulate thermogenesis in obesity management: From pharmaceuticals to functional food ingredients. Obes Rev (2011) 12(10):866ā83. doi:Ā 10.1111/j.1467-789X.2011.00909.x
+ [DOI] [PubMed] [Google Scholar]
+
+30.
+Byun SY, Kwon SH, Heo SuH, Shim JS, Du MH, Na JI. Efficacy of slimming cream containing 3.5% water-soluble caffeine and xanthenes for the treatment of cellulite: Clinical study and literature review. Ann Dermatol (2015) 27(3):243ā2495. doi:Ā 10.5021/ad.2015.27.3.243
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+32.
+Epstein E, Young VL, Schorr M, Young AE, Weisenborn S. Prospective and randomized determination of the efficacy of topical lipolytic agents. Aesthetic Surg J (1997) 17(5):304ā3075. doi:Ā 10.1016/S1090-820X(97)80019-2
+ [DOI] [PubMed] [Google Scholar]
+
+33.
+Eisenstein A, Ravid K. G Protein-coupled receptors and adipogenesis: A focus on adenosine receptors. J Cell Physiol (2014) 229(4):414ā4215. doi:Ā 10.1002/jcp.24473
+ [DOI] [PMC free article] [PubMed] [Google Scholar]
+
+34.
+Diepvens K, Westerterp KR, Westerterp-Plantenga MS. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol - Regul Integr Comp Physiol (2007) 292(1):77ā85. doi:Ā 10.1152/ajpregu.00832.2005
+ [DOI] [PubMed] [Google Scholar]
+
+35.
+Dickinson BI, GoraHarper ML. Aminophylline for cellulite removal. Ann OF PHARMACOTHERAPY (1996) 30(3):292ā3. doi:Ā 10.1177/106002809603000315
+ [DOI] [PubMed] [Google Scholar]
+
+36.
+Arnold R, Beer D, Bhalay G, Baettig U, Collingwood SP, Craig S, et al. 8-aryl xanthines potent inhibitors of phosphodiesterase 5. Bioorganic Medicinal Chem Lett (2002) 12(18):2587ā90. doi:Ā 10.1016/S0960-894X(02)00480-8
+ [DOI] [PubMed] [Google Scholar]
This section collects any data citations, data availability statements, or supplementary materials included in this article.
+
Data Availability Statement
+
The original contributions presented in the study are included in the article/
+Supplementary Material
+. Further inquiries can be directed to the corresponding author.
