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add detail on aminophylline and rib surgery

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@ -42,18 +42,22 @@ There are various GLP-1 receptor agonists drugs like semaglutide, liraglutide, d
#### Aminophylline #### Aminophylline
[Link to Meta-analysis](https://pmc.ncbi.nlm.nih.gov/articles/PMC9978326/){ .source-link }
Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in a 2:1 ratio. Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in a 2:1 ratio. It is a little-studied drug that inhibits dual phosphodiesterase (PDE) which causes cAMP to surge, and thus increase lipolysis.
It is a little-studied drug that inhibits dual phosphodiesterase (PDE) which causes cAMP to surge. * [Link to Meta-analysis](https://pmc.ncbi.nlm.nih.gov/articles/PMC9978326/){ .source-link }
In particular, one study on 25 men/women, when on a 1200kcal diet, achieved a reduction in waist circumference of 11 ± 1.0 cm when using 0.5% aminophylline, compared to a reduction of 5.0 ± 0.6 cm in the control group. In particular, [one study](https://pubmed.ncbi.nlm.nih.gov/17391155/){.source-link} on 25 men/women, when on a 1200kcal diet, achieved a reduction in waist circumference of 11 ± 1.0 cm when using 0.5% aminophylline, compared to a reduction of 5.0 ± 0.6 cm in the control group.
However, there is almost no discussion of this online. Eg: However, there is not that much discussion of this online. Here is all I could find:
- [u/brasscup used aminophylline in the 90s for cellulite](https://old.reddit.com/r/SkincareAddiction/comments/xixd9o/diy_anybody_have_a_diy_recipe_for_cellulite_cream/){.source-link}, and [another comment of them discussing it](https://old.reddit.com/r/AskWomenOver60/comments/1l8wibb/help/mx8iitq){.source-link}
- [Old blog from Tim Ferris in 2011 discussing aminophylline](https://tim.blog/2011/01/16/spot-reduction-revisited-removing-stubborn-thigh-fat/){.source-link}
- [Reddit post from u/Lopsided_Bar2863 on r/4tran4 on aminophylline and glycyrrhetinic acid](https://old.reddit.com/r/4tran4/comments/1eq12mv/poons_theres_a_lifesaver_to_reduce_your_ass/){.source-link}
- [u/brasscup on r/SkincareAddiction/ used aminophylline in the 90s for cellulite](https://old.reddit.com/r/SkincareAddiction/comments/xixd9o/diy_anybody_have_a_diy_recipe_for_cellulite_cream/){.source-link}, and [another comment of them discussing it](https://old.reddit.com/r/AskWomenOver60/comments/1l8wibb/help/mx8iitq){.source-link}
- [Other reddit post on aminophylline, one commenter seems to think transdermal caffeine is better](https://old.reddit.com/r/Splendida/comments/n9ob7l/research_on_slimming_cream/){.source-link}
- [Reddit post from u/mayoito on r/estrogel speculating about it](https://old.reddit.com/r/estrogel/comments/1guqhrl/topicals_for_losing_fat_creams_with_aminophylline/){.source-link}
- [Reddit post from /LyleVestREYI, possibly AI generated](https://old.reddit.com/r/GlimmerGrit/comments/1mgqahp/best_cold_sculpting_body_treatment_cream_2025/){.source-link}
- [Reddit post by will powers about aminophylline for vaginismus and anorgasmia (?)](https://old.reddit.com/r/vaginismus/comments/q7o2gm/a_patient_for_whom_i_make_a_custom_compound_that/){.source-link}
??? note "Sourcing, according to ChatGPT" ??? note "Sourcing, according to ChatGPT"
@ -82,6 +86,18 @@ Transdermal caffein
#### Waist-training #### Waist-training
As another option, if looking particularly to improve WHR or get a more hour-glass figure, could be waist training. This can often reduce appetite while worn. If done correctly this is usually quite safe, thought this does often cause the floating ribs 8-12 to shift inwards, and may cause some organs to move around. As another option, if looking particularly to improve WHR or get a more hour-glass figure, could be waist training. This can often reduce appetite while worn. If done correctly this is usually quite safe, thought this does often cause the floating ribs 8-12 to shift inwards, and may cause some organs to move around.
#### Rib reshaping surgery
Breaking the ribs and reshaping using a corset. Usually only targets lower floaring ribs (10-12). Basically same effect as corset but longer-lasting / doesn't need continuous maintenence.
See [Reddit wiki](https://old.reddit.com/r/TransSurgeriesWiki/wiki/other#wiki_rib_reshaping) for more info.
* Reddit: [Waist narrowing surgery by AnyaAnn in 2020](https://old.reddit.com/r/MtF/comments/g36qn0/waist_narrowing_surgery/){.source-link}
* Article: [Rib Reshaping Better Than Rib Removal For Waistline Narrowing?](https://www.eppleyplasticsurgery.com/is-rib-reshaping-better-than-rib-removal-for-waistline-narrowing/){.source-link}
#### Dangerous Darth Method #### Dangerous Darth Method
This is a subtype of "waist training". This is a subtype of "waist training".

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<strong>📄 Archived:</strong> 2025-08-09 22:31:20 UTC
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<strong>🔗 Source:</strong> <a href="https://old.reddit.com/r/4tran4/comments/1eq12mv/poons_theres_a_lifesaver_to_reduce_your_ass/">https://old.reddit.com/r/4tran4/comments/1eq12mv/poons_theres_a_lifesaver_to_reduce_your_ass/</a>
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<h1>Poons, there's a lifesaver to reduce your ass, thighs, and love handles</h1>
<p><strong>r/4tran4</strong> • by u/Lopsided_Bar2863 • 58 points</p>
<div class='post-content'><div class="md"><p>The way these parts of my body currently are, makes me want to rope, if they don't change to have a more masculine fat distribution visibly too after a few years of effort I will rope, but I'm still new on t, and fat, so it's not completely over for now as long as I put in effort, and I have been researching ways to make the lower half of my body more masculine. I will share this knowledge with the other poons.</p>
<p>Your body has a2 receptors, which tell it to store fat in areas where these receptors are most active and numerous. Estrogen tells the a2 receptors to be more active, and increases their amount. Areas of your body with more, and more active a2 receptors store the fat there, unfortunately those who are estrogen dominant, store them in the ass thighs and love handles the most, and estrogen makes these receptors more active.</p>
<p>Inhibiting the A2 repetor, or inhibition of phosphodiesterase as well, but I won't go into how this works, on that area of fat, would help that area stop storing fat and store it elsewhere. This could be done through a topical cream that inhibits the a2 receptor on a localized area of the body, or blocks phosphodiesterase there, or reduces availability of cortisol at fat cells themselves since cortisol helps store fat, or a cream that can do all of the above.</p>
<p>Aminophylline which is a bronchodilator helps inhibit a2, and glycyrrhetinic acid helps reduce availability of cortisol at fat cells. Aminiphylline 2% can be found in celluthin cream or since now celluthin is difficult to find, amilean lotion, and glycyrrhetinic acid can be found in atopiclair cream which is primarily used for dermatitis.</p>
<p>Using Atopiclair 3 times daily, and amilean two times daily, trying to wait 1 hour in between applying one and the other just to be safe, but still applying both morning noon and night will produce results, apply it to the areas with which you want to spot reduce, and ideally be on a caloric deficit at the same time. Apply multiple times a day since it's a cream as bioavailable as other medicine so it needs more often application.</p>
<p>Info from an old blog about biohacking here <a href="https://tim.blog/2011/01/16/spot-reduction-revisited-removing-stubborn-thigh-fat/">https://tim.blog/2011/01/16/spot-reduction-revisited-removing-stubborn-thigh-fat/</a></p>
<p>Oh and for true getting the most out of fat redistribution on t specifically, you have to lose fat and gain fat, your body doesn't redistribute fat that efficiently when it's not changing much. Do this over and over until fat distro is satisfactory, aka big cutting phase and big bulking face like bodybuilders say. Dr Powers sub also has info on using dht cream with t injections to masculinize further, which I am researching at the moment as well.</p>
<p>Oh, and since there are a lot of terf lurkers reading this, to all the no hrt reppoons, you can use this to redistribute fat to be more masculine in distribution even if you're not on t, though t is a must have to get full results and masculinize.</p>
<p>EDIT: Amilean has 2% aminophylline for those who struggle to find celluthin.</p>
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<h2>Comments</h2>
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<strong>u/saintmada</strong> • 10 points
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<div class="md"><p>Thanks science dood</p>
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<strong>u/DesiresAreGrey</strong> • 13 points
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<div class="md"><p>is there an opposite, cause estrogen hasn’t changed my fat distribution enough</p>
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<strong>u/cringe4tranthrowaway</strong> • 5 points
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<div class="md"><p>I believe thats what pio does!</p>
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<strong>u/DesiresAreGrey</strong> • 1 points
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<div class="md"><p>what’s that</p>
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<strong>u/strategicmagpie</strong> • 4 points
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<div class="md"><p>pioglitazone, a medication that you take for 3-6 months once to redistribute where your fat deposits are located from visceral fat (under the skin in your tummy) to subcutaneous fat (thighs, ass, boobs, anywhere else under the skin). <a href="https://grayoasis.com/post/3">there's a blog on the grayoasis website</a></p>
<p>It's also not something you take permanently, but the fat changes have a permanent effect. Because it uses bone marrow stem cells to make new fat cells in your body and thus if you take it too long your bones get all brittle. There are other side effects too AFAIK but yeah.</p>
<p>Pioglitazone is also not recommended for anamaxxers, you gotta fatmaxx while taking it to get the best results.</p>
<p>anyway that's about all I've learnt abt it, i could be wrong on some things but it's handy. I wish I could see timeline photos on pio because I wanna know how much of an effect it has lol</p>
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<strong>u/DesiresAreGrey</strong> • 1 points
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<div class="md"><p>why not recommended for anamaxxers?</p>
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<strong>u/strategicmagpie</strong> • 3 points
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<div class="md"><p>to quote the blog made by u/ fallingforpropaganda which I linked:</p>
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<p>It also can lead to some negative long term side effects (discussed in section 3), so it is advised to not go past a year of continuous use and to keep lifetime exposure minimal. Therefore, I’d only recommend using it while intentionally gaining weight, and only for a maximum of 6 months to a year at a time.</p>
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<strong>u/Fun-Possession554</strong> • 1 points
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<div class="md"><p>Interesting if it has any lifelong side effects after you drop it.</p>
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<strong>u/strategicmagpie</strong> • 3 points
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<div class="md"><p>probably not lifelong but fat cells go through a full lifecycle every 7 years so it's like a jumpstart. Because otherwise those fat deposits are slower to change</p>
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<strong>u/Fun-Possession554</strong> • 1 points
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<div class="md"><p>Hmm sounds reeeally interesting. So you can kind of speedrun fat redistribution in months instead of years. I have skinny ass while my mom's is proportionally thicker than average and I've got her body type 👀</p>
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<strong>u/cringe4tranthrowaway</strong> • 1 points
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<div class="md"><p>I think it’s call pioglatazone or something? I know it’s traditionally used as an anti diabetic med but some of the ladies here have used it to help force fat redistribution. I mostly only know about it from memes, I wish I could tell you more but I know there are people on this subreddit who know about it</p>
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<strong>u/Lopsided_Bar2863</strong> • 2 points
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<div class="md"><p>Now that I think of it, perhaps you can use it on the undereye area, and the brow ridge area to encourage fat storage there, giving you a more masculine 'hunter eye' look as fat storage in these areas gives the eyes a narrower, more square hooded look.</p>
<p>Adipeau cream could work for fat accumulation purposes too. </p>
<p><a href="https://www.reddit.com/r/30PlusSkinCare/comments/s1lqdz/anyone_using_adyfiline_sidmool_volufiline_other/">https://www.reddit.com/r/30PlusSkinCare/comments/s1lqdz/anyone_using_adyfiline_sidmool_volufiline_other/</a></p>
<p>And any of these products can be used for both purposes, to volumize fat cells in face and body areas.</p>
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<strong>u/Lopsided_Bar2863</strong> • 3 points
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<div class="md"><p>If I find out more I'll tell you, but you can use the creams on your masculine fat distributed areas while in a caloric maintenance and that will probably make the fat migrate to feminine fat distribution areas if you're on hrt properly. Caloric maitenance is better for this, though if you don't see results in a month try with surplus/deficit or just stick to this.</p>
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<strong>u/Lopsided_Bar2863</strong> • 2 points
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<div class="md"><p>I think I remember, also adipeau cream helps existing fat cells in an area increase in volume, giving it a fuller fatter essence and appearance.</p>
<p>So apply adipeau cream to areas you want to fatten up too.</p>
<p><a href="https://www.reddit.com/r/30PlusSkinCare/comments/s1lqdz/anyone_using_adyfiline_sidmool_volufiline_other/">https://www.reddit.com/r/30PlusSkinCare/comments/s1lqdz/anyone_using_adyfiline_sidmool_volufiline_other/</a></p>
<p>also possibly any of these products applied to the skin too</p>
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<strong>u/legofan_1</strong> • 4 points
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<div class="md"><p>This post and the comments under this are quite nice, because now I'm learning interesting things that will definitely aid me in my journey to chubbymaxx<br/>
Would using Atopiclair help to limit fat build up in the belly area while fatmaxxing for everything else (thighs, hips, ass, breasts) help?</p>
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<strong>u/Lopsided_Bar2863</strong> • 5 points
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<div class="md"><p>Yes, it would. It could even help redirect fat from that area to a feminine fat distribution as long as you are on a proper form of feminizing hrt that actually works, not a hondose.</p>
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<strong>u/strategicmagpie</strong> • 2 points
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<div class="md"><p>pioglitazone moves fat away from the visceral fat around your organs afaik so you don't need to do that. It was originally a drug for diabetes.</p>
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<strong>u/throwawayacc2735</strong> • 2 points
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<div class="md"><p>Is there any good alternative to celluthin? Bc it's not available in the UK.</p>
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<strong>u/Artyartymushroom</strong> • 2 points
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<div class="md"><p>This is an older post but I'm genuinely wondering if there's anyway to buy something similar to this in the UK because my lower body is so bad, even though I'm on the skinny side</p>
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<strong>u/throwawayacc2735</strong> • 1 points
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<div class="md"><p>OP says Amilean</p>
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<strong>u/[deleted]</strong> • 1 points
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<div class="md"><p>Thank you, you're a life saver </p>
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<strong>📄 Archived:</strong> 2025-08-09 22:31:21 UTC
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<strong>🔗 Source:</strong> <a href="https://old.reddit.com/r/estrogel/comments/1guqhrl/topicals_for_losing_fat_creams_with_aminophylline/">https://old.reddit.com/r/estrogel/comments/1guqhrl/topicals_for_losing_fat_creams_with_aminophylline/</a>
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<h1>Topicals for losing fat: creams with aminophylline and glycyrrhetinic acid</h1>
<p><strong>r/estrogel</strong> • by u/mayoito • 21 points</p>
<div class='post-content'><div class="md"><p>To help with the process of weight cycling, people are now using glitazones to gain fat "in the right places", but it seems to only help during the weight gain phase.</p>
<p>What about the weight loss phase?</p>
<p>Good news is some topicals could help: aminophylline creams with maybe glycyrrhetinic acid.</p>
<p>Aminophilline is backed by recent research (2023) in <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9978326/">https://pmc.ncbi.nlm.nih.gov/articles/PMC9978326/</a> and the use of this combination has detailed explanation on a blogpost <a href="https://tim.blog/2011/01/16/spot-reduction-revisited-removing-stubborn-thigh-fat/">https://tim.blog/2011/01/16/spot-reduction-revisited-removing-stubborn-thigh-fat/</a> that seem to have been right even before all the conclusive evidence was gathered.</p>
<p>Based on the pubmed article, there's more evidence for 0.5% aminophylline than for any other concentration (like 2%), however given how aminophylline works, the response curve should be linear so it's more likely there hasn't been enough studies in the final sample (out of the selected 17 studies, only 5 were kept) to make it clear</p>
<p>In theory, the effect of glycyrrhetinic acid would be synergestic with aminophylline, or at least cumulative, however it's been far less studied</p>
<p>I'd suggest whoever is interested in topical fat loss to only consider that a dangerous experiment: it's not clear yet how to formulate these 2 products: a review of the different amazon products featuring aminophylline shows a lot of people complaining that more recent batches of their favorite products have been less efficient that before</p>
<p>Given how products are "reformulated" to cut costs when they become more popular, it's likely the carrier part plays a strong role in how much how the aminophylline is absorbed by the skin.</p>
<p>Still I'd suggest to stick to amazon products while more eyeballs study how to formulate these 2 products into something efficient to be more absorbed, to avoid suggesting something "too efficient" as aminophylline is a PDE (like viagra is, but more broad spectrum) and therefore with potential cardiovascular effects (like increasing the heart rate too much)</p>
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<strong>u/Emmasissybisex</strong> • 4 points
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<div class="md"><p>Do you have links for some products that contains both of them ?</p>
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<strong>u/mayoito</strong> • 5 points
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<div class="md"><p>sorry but don't</p>
<p>this is just a very preliminary post to suggest the use of these substances, that are apparently not very well known on reddit</p>
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<strong>u/PlantainNo3498</strong> • 1 points
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<div class="md"><p>I'm starting an experiment using aminophylline (bought OTC) dissolved in cream, on my arms and belly.</p>
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<strong>📄 Archived:</strong> 2025-08-09 22:31:20 UTC
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<h1>Best Cold Sculpting Body Treatment Cream [2025 Reviews]</h1>
<p><strong>r/GlimmerGrit</strong> • by u/LyleVestREYI • 1 points</p>
<div class='post-content'><div class="md"><p><a href="https://blogs.perfectshome.com/clearance-inventory/?kw=cold%20sculpting%20body%20treatment%20cream">[Check Latest Arrivals cold sculpting body treatment cream on Amazon.]</a></p>
<h1>best Cold Sculpting Body Treatment Cream [2025 reviews]</h1>
<p>The desire for a sculpted physique without invasive procedures has fueled the popularity of cold sculpting body treatment creams. These creams promise to mimic the effects of cryolipolysis, a non-surgical fat reduction technique, by using specific ingredients that claim to target and reduce subcutaneous fat. The best creams offer a convenient and perhaps cost-effective way to complement diet and exercise for enhanced body contouring. Choosing the right cream,though,requires careful consideration of its ingredients,efficacy,and user reviews to ensure optimal results and safety.</p>
<p><a href="https://blogs.perfectshome.com/clearance-inventory/?kw=cold%20sculpting%20body%20treatment%20cream">[Explore Top Rated cold sculpting body treatment cream on Amazon.]</a></p>
<h2>Key Features Analysis</h2>
<p>The effectiveness of cold sculpting body treatment creams hinges on several key features, including their active ingredients, formulation, delivery system, and supporting studies. These elements work together to potentially provide visible improvements in body contouring and skin tone.</p>
<p><strong>Active Ingredients:</strong></p>
<p>The cornerstone of any effective cold sculpting cream lies in its active ingredients. Look for ingredients like caffeine, known for its ability to stimulate lipolysis (fat breakdown) and improve circulation. Other beneficial components include forskolin, derived from the Indian coleus plant, which purportedly boosts cAMP levels, encouraging fat breakdown. Furthermore, ingredients such as aminophylline are sometimes included to constrict blood vessels and reduce the appearance of cellulite. The inclusion of clinically studied ingredients at efficacious dosages is crucial for achieving noticeable results.</p>
<p><strong>Cream Formulation:</strong></p>
<p>The overall formulation of the cream can significantly impact its efficacy. A well-formulated cream will incorporate ingredients that enhance penetration into the skin, allowing the active components to reach the subcutaneous fat layers where they can exert their effects.Look for creams that include penetration enhancers such as phospholipids or liposomes. The texture and consistency of the cream also matter; a non-greasy, fast-absorbing formula is generally preferred for user convenience and compliance.</p>
<p><strong>Delivery System:</strong></p>
<p>The delivery system refers to how the active ingredients are transported into the skin. advanced delivery systems like microencapsulation or nano-technology can improve the stability and penetration of the active ingredients. Microencapsulation,for instance,protects the ingredients from degradation and allows for a controlled release over time,enhancing their effectiveness. Opting for creams with innovative delivery systems can potentially lead to better and more sustained results.</p>
<p><strong>Clinical Studies and Reviews:</strong></p>
<p>While anecdotal evidence and product claims are helpful, the presence of clinical studies supporting the cream's efficacy is a meaningful plus. Look for creams that have undergone testing on human subjects, demonstrating measurable improvements in fat reduction, skin firmness, or cellulite reduction. User reviews, especially from a diverse range of users, can provide valuable insights into the cream's real-world performance, including potential side effects and overall satisfaction.</p>
<p>Key features of the best cold sculpting creams include:</p>
<ul>
<li> Scientifically-backed active ingredients</li>
<li> Effective penetration enhancers</li>
<li> advanced delivery systems</li>
<li> Positive clinical studies and reviews</li>
</ul>
<p><a href="https://blogs.perfectshome.com/clearance-inventory/?kw=cold%20sculpting%20body%20treatment%20cream">[Explore Top Rated cold sculpting body treatment cream on Amazon.]</a></p>
<h2>Core Benefits</h2>
<p>The core benefits of using a cold sculpting body treatment cream extend beyond just potential fat reduction. The best creams offer a combination of skin firming,cellulite reduction,and improved overall skin health. These benefits contribute to a more toned and sculpted appearance.<strong>Skin Firming &amp; Tightening:</strong></p>
<p>Manny cold sculpting creams contain ingredients that promote collagen production, contributing to firmer and tighter skin. Ingredients like peptides and retinoids can stimulate collagen synthesis, improving skin elasticity and reducing sagging. This benefit is particularly desirable for targeting areas prone to laxity, such as the abdomen, thighs, and upper arms. over time, consistent use of a skin-firming cream can lead to a noticeable betterment in skin texture and tone.</p>
<p><strong>Cellulite Reduction:</strong></p>
<p>Cellulite, characterized by dimpled skin caused by subcutaneous fat deposits, is a common concern for many individuals. Some cold sculpting creams contain ingredients that target cellulite by improving blood circulation, reducing inflammation, and promoting the breakdown of fat cells.Caffeine, as an example, is known to constrict blood vessels and reduce the appearance of cellulite. Regular submission of these creams, combined with massage, can help to smooth out the skin's surface and diminish the visibility of cellulite.</p>
<p><strong>Improved Skin Tone &amp; Texture:</strong></p>
<p>beyond targeting fat and cellulite, many cold sculpting creams incorporate ingredients that improve overall skin tone and texture. Antioxidants like vitamin C and E can protect the skin from free radical damage, brightening the complexion and reducing the appearance of age spots. Hydrating ingredients such as hyaluronic acid and shea butter can nourish the skin, leaving it feeling soft, smooth, and supple. A well-formulated cream can thus enhance the overall health and appearance of the skin.</p>
<p><a href="https://blogs.perfectshome.com/clearance-inventory/?kw=cold%20sculpting%20body%20treatment%20cream">[Explore Top Rated cold sculpting body treatment cream on Amazon.]</a></p>
<h2>FAQs Section</h2>
<p>Addressing common questions about cold sculpting body treatment creams can help consumers make informed decisions and set realistic expectations. Understanding the limitations,potential side effects,and proper usage of these products is crucial.</p>
<p><strong>How long does it take to see results?</strong></p>
<p>Results typically vary depending on individual factors such as skin type, diet, exercise habits, and the specific product used. Most creams recommend consistent application for several weeks or months before noticeable improvements are observed.While some users may see initial changes within a few weeks, significant results generally require long-term commitment and a healthy lifestyle.</p>
<p><strong>Are there any potential side effects?</strong></p>
<p>While generally safe for topical use, some individuals may experience side effects such as skin irritation, redness, itching, or allergic reactions.It's essential to perform a patch test before applying the cream to a large area of the body. People with sensitive skin or pre-existing skin conditions should exercise caution and consult with a dermatologist before using cold sculpting body treatment creams.</p>
<p><strong>Can cold sculpting creams replace professional cryolipolysis treatments?</strong></p>
<p>no, cold sculpting creams are not a substitute for professional cryolipolysis procedures. Cryolipolysis uses controlled cooling to freeze and eliminate fat cells, delivering more significant and permanent results. Cold sculpting creams may offer some complementary benefits by potentially improving skin tone, reducing cellulite, and providing a temporary tightening effect, but they cannot replicate the fat-reducing capabilities of professional treatments.</p>
<p><a href="https://blogs.perfectshome.com/clearance-inventory/?kw=cold%20sculpting%20body%20treatment%20cream">[Explore Top rated cold sculpting body treatment cream on Amazon.]</a></p>
<h2>Competitor Comparison</h2>
<p>Understanding how different cold sculpting body treatment creams compare in terms of ingredients, formulation, and user reviews can definitely help consumers make informed choices. Comparing a few leading products highlights their respective strengths and weaknesses.</p>
<h3>Product Comparison Overview</h3>
<h4>[Cream A Name: CelluSculpt Pro]</h4>
<ul>
<li><strong>Active Ingredients:</strong> Caffeine, Forskolin, Retinol</li>
<li><strong>Delivery System:</strong> Liposome Encapsulation</li>
<li><strong>User Reviews:</strong> Highly rated for skin firming and texture improvements, some complaints about mild irritation.</li>
</ul>
<h4>[cream B Name: Sculpt &amp; Tone FX]</h4>
<ul>
<li><strong>Active Ingredients:</strong> Caffeine, Aminophylline, Green Tea Extract</li>
<li><strong>Delivery System:</strong> Standard Cream Formulation</li>
<li><strong>User Reviews:</strong> Mixed reviews, some users report cellulite reduction, others see minimal change.</li>
</ul>
<h4>[Cream C Name: CryoContour Max]</h4>
<ul>
<li><strong>Active Ingredients:</strong> Caffeine,L-Carnitine,Hyaluronic Acid</li>
<li><strong>Delivery System:</strong> Micro-Encapsulation</li>
<li><strong>User Reviews:</strong> Positive reviews for hydration and overall skin appearance,less consistent feedback on fat reduction.</li>
</ul>
<h3>Key Differences Summary</h3>
<p>cellusculpt Pro stands out for its use of both Caffeine and Retinol, which target fat and boost collagen production respectively.Its liposome encapsulation delivery system might aid in better penetration, potentially leading to more noticeable skin firming. Sculpt &amp; Tone FX includes Aminophylline, an ingredient known for vasoconstriction, which some users may find effective for reducing cellulite appearance. CryoContour Max's strengths lie in its hydrating properties due to hyaluronic acid, appealing to users prioritizing overall skin health alongside potentially some fat reduction.For users seeking a potent cream focused on skin firming, CelluSculpt Pro might be better, while those prioritizing hydration could favor CryoContour Max.</p>
<p><a href="https://blogs.perfectshome.com/clearance-inventory/?kw=cold%20sculpting%20body%20treatment%20cream">[Explore Top Rated cold sculpting body treatment cream on Amazon.]</a></p>
<h2>Ideal User Profile</h2>
<p>cold sculpting body treatment creams are most beneficial for specific user groups. Identifying these "ideal users" helps manufacturers better target their marketing and allows consumers to determine if a product is likely to work for them.</p>
<p><strong>Individuals Seeking Complementary Body Contouring:</strong></p>
<p>These creams are ideal for individuals who already follow a healthy diet and exercise regimen and are looking for a complementary product to enhance their body contouring efforts. They should have realistic expectations and understand that these creams are not a magic bullet but rather a tool that may provide subtle improvements alongside a healthy lifestyle. They are seeking to improve skin firmness, reduce cellulite appearance, and achieve a more toned physique.</p>
<p><strong>Users with Mild Cellulite or Skin Laxity:</strong></p>
<p>cold sculpting creams may be particularly beneficial for individuals with mild cellulite or skin laxity who are looking for a non-invasive solution to improve skin appearance. These creams can potentially provide a temporary tightening effect and reduce the visibility of cellulite, making them a suitable option for those seeking aesthetic improvements without resorting to professional procedures.</p>
<p><a href="https://blogs.perfectshome.com/clearance-inventory/?kw=cold%20sculpting%20body%20treatment%20cream">[Explore Top Rated cold sculpting body treatment cream on Amazon.]</a></p>
<h2>Buying Recommendations &amp; Conclusion</h2>
<p>The decision to purchase a cold sculpting body treatment cream should be based on careful evaluation of individual needs, product features, and realistic expectations. Weigh the pros and cons to determine if a particular cream aligns with your goals and requirements.</p>
<p>When choosing a cold sculpting cream, consider the active ingredients, delivery system, and user reviews. Look for creams with clinically studied ingredients,effective penetration enhancers,and positive feedback regarding skin firming and cellulite reduction. Remember that results can vary, and consistent application is key.</p>
<p>cold sculpting body treatment creams can be a valuable addition to a healthy lifestyle for individuals seeking complementary body contouring. While they are not a substitute for professional treatments or a balanced diet and exercise, they can potentially provide subtle improvements in skin firmness, cellulite appearance, and overall skin health. Choose wisely and manage expectations for the best possible outcome.</p>
<p><a href="https://blogs.perfectshome.com/clearance-inventory/?kw=cold%20sculpting%20body%20treatment%20cream">[Shop budget-Amiable cold sculpting body treatment cream on Amazon.]</a></p>
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<h2>Comments</h2>

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<strong>📄 Archived:</strong> 2025-08-08 14:39:26 UTC
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<strong>🔗 Source:</strong> <a href="https://old.reddit.com/r/MtF/comments/g36qn0/waist_narrowing_surgery/">https://old.reddit.com/r/MtF/comments/g36qn0/waist_narrowing_surgery/</a>
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<h1>Waist narrowing surgery</h1>
<p><strong>r/MtF</strong> • by u/[deleted] • 3 points</p>
<div class='post-content'><div class="md"><p>[deleted]</p>
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<strong>u/misscolinsxx</strong> • 3 points
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<div class="md"><p>I don’t think such surgery exists where they break your rib and you wear a corset. Liposuction can help though</p>
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<strong>u/HatchingCougar</strong> • 1 points
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<div class="md"><p>It exists, it’s just so extremely rare that it makes lower rib removal look like it’s common.</p>
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<strong>u/HiddenStill</strong> • 1 points
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<div class="md"><p>Do you have any links?</p>
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<strong>u/HatchingCougar</strong> • 1 points
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<div class="md"><p><a href="https://www.eppleyplasticsurgery.com/is-rib-reshaping-better-than-rib-removal-for-waistline-narrowing/">https://www.eppleyplasticsurgery.com/is-rib-reshaping-better-than-rib-removal-for-waistline-narrowing/</a></p>
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<strong>u/HiddenStill</strong> • 1 points
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<div class="md"><p>Thanks, I added it to the wiki</p>
<p><a href="https://www.reddit.com/r/TransSurgeriesWiki/wiki/other">https://www.reddit.com/r/TransSurgeriesWiki/wiki/other</a></p>
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<strong>u/clear-pine</strong> • 3 points
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<div class="md"><p>waist training via tightlacing doesn't require surgery, plus it's pretty</p>
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<strong>u/TheInsaneBlacksmith</strong> • 3 points
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<div class="md"><p>You don't need to really tight lace, just wearing a good corset can give you the results you want. It just takes a while</p>
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<strong>u/ZestyChinchilla</strong> • 3 points
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<div class="md"><p>Waist training with corsets isn't permanent, but it <em>can</em> potentially damage internal organs if you're not careful.</p>
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<strong>u/TheInsaneBlacksmith</strong> • 2 points
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<div class="md"><p>It's pretty permanent, like after a year of wearing it you can go three months without it and still have around the same size waist. Also the internal organ damage thing isn't really a thing. People used to go to 16 inch waists and while it did move things around it isn't super dangerous. Unless you go from like 37 to 19 with the first corset and even than it's from loss of blood circulation.</p>
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<strong>u/kynkao</strong> • 4 points
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<div class="md"><p>Yep yep yep, there's a lot of misinformation and fear mongering around the use of corsets.</p>
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<strong>u/ZestyChinchilla</strong> • 1 points
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<div class="md"><p>Okay</p>
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<strong>u/Praxxis2112</strong> • 2 points
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<div class="md"><p>You're thinking of Amanda Lepore. I read an article back in the 90's about her getting her ribs broken and reshaped with a corset. Google her name and a lot of stuff comes up.</p>
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<strong>📄 Archived:</strong> 2025-08-09 22:31:21 UTC
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<h1>Research on slimming cream</h1>
<p><strong>r/Splendida</strong> • by u/sculptedmermaid • 29 points</p>
<div class='post-content'><div class="md"><p>I just heard of aminophylline from reading Tim Ferris blog. Using an n of 1 he tried it on one thigh and not the other and that thigh reduced in size. </p>
<p><a href="https://tim.blog/2011/01/16/spot-reduction-revisited-removing-stubborn-thigh-fat/">https://tim.blog/2011/01/16/spot-reduction-revisited-removing-stubborn-thigh-fat/</a></p>
<p>Below are several peer reviewed studies that show it’s efficacy (edit - and that’s the only reason I’m sharing this don’t downvote me the science shows it helps. Two groups had a exercise regimen and the group that used the cream lost more circumference than the placebo group.)
FYI this ingredient is contraindicated for asthma. </p>
<p><a href="https://pubmed.ncbi.nlm.nih.gov/30456780/">https://pubmed.ncbi.nlm.nih.gov/30456780/</a></p>
<p><a href="https://journals.sagepub.com/doi/abs/10.1177/875512259701300209?journalCode=pmta">https://journals.sagepub.com/doi/abs/10.1177/875512259701300209?journalCode=pmta</a> </p>
<p><a href="https://dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1463-1326.2006.00600.x?deniedAccessCustomisedMessage=&amp;userIsAuthenticated=false">https://dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1463-1326.2006.00600.x?deniedAccessCustomisedMessage=&amp;userIsAuthenticated=false</a></p>
<p>There are links to several studies and discussions on this forum: <a href="https://forums.t-nation.com/t/topical-fat-loss/164469/4">https://forums.t-nation.com/t/topical-fat-loss/164469/4</a></p>
<p>I was skeptical but if you try it (along with exercise) worst case it was a waste of $...</p>
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<h2>Comments</h2>
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<strong>u/[deleted]</strong> • 40 points
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<div class="md"><p>There are no quick fixes to “slimming” that require little to no effort and have significant results. In the study, both the aminophylline and the placebo group had a walking regimen (leg workout) and CALORIC DEFICIT that lead to results. Both groups had very similar results.
If you want to be slimmer, a caloric deficit is the way. Working out is for toning- you can’t exercise away a bad diet. Want to level up? Put in the effort or get surgery. There are no shortcuts. Worst case scenario is also not wasted $ when it comes to WL drugs.</p>
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<strong>u/TenthPlanet-</strong> • 13 points
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<div class="md"><p>Did I misread/misinterpret the results?</p>
<p>Particularly on the study related to waist circumference, the BMI reduction was the same between groups but the aminophylline group had an 11 +/- 1cm waist reduction compared to 5.0 +/- 0.6cm in the control. That is definitely a significant difference!</p>
<p>What I take away from the study is that while exercise and calorie deficit is still required to lose the weight, this cream helps proportionately more fat be lost from the stomach.</p>
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<strong>u/darthemofan</strong> • 7 points
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<div class="md"><blockquote>
<p>What I take away from the study is that while exercise and calorie deficit is still required to lose the weight, this cream helps proportionately more fat be lost from the stomach.</p>
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<p>Yes, science works. Celebs wont be using that bc they aren't risk takers. They want safety and known good results backed by years of experience.</p>
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<strong>u/TenthPlanet-</strong> • 4 points
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<div class="md"><p>Exactly. I'm not sure how many studies there are on aminophylline/targeted weight loss, but a super quick look through the literature only shows a handful since the 21st century. </p>
<p>I highly doubt any beauty expert would be recommending a treatment with only a few studies backing it just from fear of repercussions if it doesnt work/goes wrong! </p>
<p>Also even celebrities cant have a treatment before its invented. Aminophylline for targeted fat removal is relatively new and the research on it seems to be slow.</p>
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<strong>u/darthemofan</strong> • 3 points
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<div class="md"><blockquote>
<p>Exactly. I'm not sure how many studies there are on aminophylline/targeted weight loss, but a super quick look through the literature only shows a handful since the 21st century. </p>
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<p>Yeah it's just super new so most ppl don't know yet. But like you, I trust science :) </p>
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<p>Also even celebrities cant have a treatment before its invented. Aminophylline for targeted fat removal is relatively new and the research on it seems to be slow.</p>
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<p>I'm not super familiar with it, but more with the litterature behid caffeine, and I think you are on something.</p>
<p>I just posted some links for you if you want to go on with your plan!</p>
<p>I'm a bit busy ATM but if you want to make your own DIY caffeine topical I'll be happy to help!</p>
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<strong>u/sculptedmermaid</strong> • 7 points
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<div class="md"><p>bodybuilders actually are the ones ahead of the curve on all these things not celebrities.</p>
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<strong>u/Fabulous-Appeal-6885</strong> • 1 points
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<div class="md"><p>Any update?</p>
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<strong>u/TenthPlanet-</strong> • 3 points
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<div class="md"><p>You're an angel I would absolutely love help with that!</p>
<p>P.s I just read your other comment and was so suprised! Liposomes are in my field of research (nanoscience)! I'll have fun reading through those studies tonight :)</p>
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<strong>u/Normal_Ad2456</strong> • 13 points
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<div class="md"><p>True, if there was something so simple and easy, all those rich celebrities such as Oprah, Adele, Rihanna etc wouldn’t be struggling with their weight for decades. If they don’t have the fix, then it probably doesn’t exist.</p>
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<strong>u/sculptedmermaid</strong> • 4 points
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<div class="md"><p>I think that goes without saying!</p>
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<strong>u/darthemofan</strong> • 7 points
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<div class="md"><p>Interesting, I've heard the same on transdermal caffein (in the study you quoted, it's not just aminophylline)</p>
<p>I had made a post with recipes, just can't find it ATM.</p>
<p>But check</p>
<p>"Non-ionic surfactant based vesicular drug delivery system for topical delivery of caffeine for treatment of cellulite: design, formulation, characterization, histological anti-cellulite activity, and pharmacokinetic evaluation. " <a href="https://pubmed.ncbi.nlm.nih.gov/28956468/">https://pubmed.ncbi.nlm.nih.gov/28956468/</a> </p>
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<p>Cellulite is a common topographical alteration where skin acquires an orange peel or mattress appearance with alterations in adipose tissue and microcirculation. This work aims to develop and evaluate a topical niosomal gel formulae with good permeation to reach the subcutaneous fat layer. Several caffeine niosomal dispersions were prepared and incorporated into gel formulae using Carbopol 940 polymer, chemical penetration enhancers, and iontophoresis, then the prepared gels were applied onto the skin of rats and anticellulite activity of caffeine from the prepared gels compared to that of the commercial product Cellu Destock® was evaluated by histological study of the skin and measurement of plasma level of caffeine passing through the skin using liquid chromatography (LC/MS-MS). Results of histology revealed reduction of size and thickness of fatty layer of rat skin in the following order: FVII &gt; FXIV &gt; Cellu Destock® &gt; FVII + Iontophoresis &gt; FXIV + Iontophoresis. Pharmacokinetic results of caffeine in plasma revealed that Cmax, Tmax, and AUC0-12h decreased in the following order: FXIV &gt; FVII &gt; Cellu Destock®. These results conclude that incorporation of caffeine niosomal dispersion into gel matrix with penetration enhancers and iontophoresis resulted in improvement in penetration of caffeine through the skin into the underlying fatty layer in treatment of cellulite.</p>
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<p>"Anti-obesity effect of a novel caffeine-loaded dissolving microneedle patch in high-fat diet-induced obese C57BL/6J mice." <a href="https://pubmed.ncbi.nlm.nih.gov/28389409/">https://pubmed.ncbi.nlm.nih.gov/28389409/</a></p>
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<p>Natural products such as caffeine have been found to be effective in reducing body weight through lipolysis. Here, we report the successful loading of caffeine onto dissolving microneedle following inhibition of its crystal growth by hyaluronic acid (HA), the matrix material of the dissolving microneedle (DMN). Further, the anti-obesity activity of caffeine was evaluated in high-fat diet-induced obese C57BL/6J mice. After 6weeks of caffeine loaded dissolving microneedle patch (CMP) administration, lipolysis improved significantly as shown by leptin and adiponectin activity, which resulted in considerable weight loss of about 12.8±0.75% in high-fat diet-induced obese mice. Comparison of the levels of triglyceride, total cholesterol, high-density lipoprotein (HDL)-cholesterol, and low-density lipoprotein (LDL)-cholesterol after CMP administration with the initial levels in obese mice indicated significant anti-obesity activity of CMP. These findings suggested that a novel CMP with an increased amount of caffeine loaded onto DMN has therapeutic activity against obesity. </p>
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<p>"Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study " - <a href="https://pubmed.ncbi.nlm.nih.gov/32266024/">https://pubmed.ncbi.nlm.nih.gov/32266024/</a></p>
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<p>Penetration of any compound into the body from the outside is prevented primarily by the corneal layer of the epidermis. The only way to circumvent the properties of the corneal layer is to disrupt it. Currently, transdermal systems can currently only deliver drugs that are of low molecular weight. The purpose of the present study was to assess the improvement of the slimming cream's efficacy using a novel fabric, with the aim of developing an improved method for transdermal drug delivery. The current study was conducted on four groups of guinea pigs. The control group was untreated, whereas the test groups were treated with either slimming cream and no fabric, slimming cream with 100% cotton fabric or slimming cream with the novel fabric. Ultrasound and microscopic histological analysis were used to assess animals. The results demonstrated that compared with the other groups, the novel fabric group demonstrated the greatest reductions in fat layer thickness, adipocyte size and number and proliferator-activated receptor-γ levels in adipose tissue. Furthermore, the novel fabric also enhanced the transdermal delivery of rhodamine B base and caffeine penetration compared with the control fabric (3.18-fold). In conclusion, the results of the present study demonstrated that the novel fabric can potentially be used to enhance transdermal drug delivery. </p>
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<p>If you want to do that, I'd suggest skipping aminophylline, yohimbine, carnitine (etc) and just making niosomes with a caffeine powder off amazon - <a href="https://en.wikipedia.org/wiki/Niosome">https://en.wikipedia.org/wiki/Niosome</a> as there's a lot of evidence in favor of topical caffeine causing fat loss (and little contra indications for coffee lol)</p>
<p>If you want to learn how to homebrew, check <a href="/r/diybeauty">r/diybeauty</a> <a href="/r/estrogel">r/estrogel</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/24220497/">https://pubmed.ncbi.nlm.nih.gov/24220497/</a> <a href="https://pubmed.ncbi.nlm.nih.gov/27145899/">https://pubmed.ncbi.nlm.nih.gov/27145899/</a> ; you don't need a lot of equipment if you stick to liposomes/ethosomes/niosomes - except maybe an ultrasound jewelry cleaner.</p>
<p>Google for the Mozafari method and its adaptations, it can be a bit ghetto but it works at home with limited supplies and equipment!</p>
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<strong>u/lily_2020</strong> • 2 points
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<div class="md"><p>Hello can you elborate more
I have hard tike understanding
So caffeine rubbing topically will cause fat loss
And ho to do it</p>
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<strong>u/demonette55</strong> • 1 points
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<div class="md"><p>I’m a little late to the party but am also interested in this!</p>
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<strong>📄 Archived:</strong> 2025-08-09 22:31:21 UTC
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<strong>🔗 Source:</strong> <a href="https://old.reddit.com/r/vaginismus/comments/q7o2gm/a_patient_for_whom_i_make_a_custom_compound_that/">https://old.reddit.com/r/vaginismus/comments/q7o2gm/a_patient_for_whom_i_make_a_custom_compound_that/</a>
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<h1>A patient for whom I make a custom compound that worked very well for his vaginismus asked that I post about it here.</h1>
<p><strong>r/vaginismus</strong> • by u/Drwillpowers • 39 points</p>
<div class='post-content'><div class="md"><p>Hi there! I'm Dr. Powers, I'm a family physician in Detroit MI. </p>
<p>I mostly treat transgender patients, and as a result, I treat many transgender men, some who struggle sometimes with Vaginismus. </p>
<p>I developed a few compounded drugs for them that really seem to help, and my patient wanted me to list them here. This is a compound that helped him with significant pain with penetration, and after using it for awhile, he no longer finds it necessary. <strong>These are not things that I sell</strong>. These are <strong>just the formulae</strong>. Your own doctor can <strong>write a prescription to a local compounding pharmacy</strong> for them. </p>
<p><strong>Dr Powers Vaginismus Cream- Nitroglycerin 0.1%+Diltiazem 2% + Diazepam 1% SIG: Apply 1 gram to vaginal introitus 10 minutes before sexual activity. (Can be placed deeper if necessary via an application rod like those used for BV/yeast treatment if needed).</strong> </p>
<p>I adapt the compound to different patients, some patients don't need all 3 ingredients, but the nitroglycerin works basically like topical "poppers". Some patients need that one removed if they get a headache from it. It causes the smooth muscles of the vagina to relax. Diltiazem is a calcium channel blocker that improves blood flow and relaxes muscles as well, and diazepam is valium, which is another solid muscle relaxant. </p>
<p>The three of them together work synergistically and make the opening of the vagina go pretty limp and relaxed. </p>
<p>I also do make a product for anorgasmia which sometimes patients with vaginismus also have. </p>
<p><strong>Dr Powers Scream Cream V2.0 Aminophylline 30 mg/mL, Ergoloid Mesylate 0.5 mg/mL, Pentoxifylline 50 mg/mL, Sildenafil Citrate 10 mg/mL, L-Arginine 60 mg/mL 30 mL Pump Apply 1/2 ml to clitoris 15 minutes before intercourse</strong> </p>
<p>Again, I cannot provide these for you and you cannot buy them anywhere online. These are just formulas, but they work really well for my patients, and you could ask your doctor for a prescription to give to a local compounding pharmacy to have them made for you if your doctor thinks they would be medically appropriate and safe for your individual health. I can't tell you if they would be safe for you or not (the main risk with the compounds is lowered blood pressure, and some people require lower doses of the constituent medications to not get side effects). </p>
<p>I hope I haven't offended anyone or broken any rules by posting this, but I just wanted to do what my patient asked me to do and share this info here as it was helpful for them. Feel free to remove my post or whatever if its not appropriate for this community.</p>
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<strong>u/Zelosd</strong> • 1 points
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<div class="md"><p>Dr powers hmmm?</p>
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<strong>📄 Archived:</strong> 2025-08-09 22:44:23 UTC
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<strong>🔗 Source:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/17391155/">https://pubmed.ncbi.nlm.nih.gov/17391155/</a>
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<h1>Topical fat reduction from the waist</h1>
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Objective:
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Topical fat reduction from the thigh in women using aminophylline cream has been demonstrated, but the local fat reduction in other body areas or in men by lowering the local lipolytic threshold has not been demonstrated. This study is designed to test the hypothesis that aminophylline cream application to the waist will reduce waist circumference compared with a control.
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Fifty men and women who are 21-65 years of age with a BMI greater than 27 kg/m(2) and a waist to hip ratio &gt; or =average were randomized in a 1 : 1 ratio to 0.5% aminophylline cream to the waist twice a day or no treatment to the waist. All subjects were instructed to follow a 1200 kcal balanced diet, participate in a walking program and return biweekly to encourage compliance. A theophylline level was drawn monthly, and the waist, BMI and waist to hip ratio were remeasured at 12 weeks.
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Results:
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At week 12, there was a significant reduction in BMI from baseline that was not different between the groups. The reduction in waist circumference was 11 +/- 1.0 cm in the aminophylline cream group and 5.0 +/- 0.6 cm in the control group (p &lt; 0.001). The reduction in waist circumference was significant for both women and men, but the women lost significantly more waist girth. The waist to hip ratio, a measure of fat distribution, declined. Aminophylline levels were undetectable, and there were no adverse events.
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Discussion:
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Aminophylline cream offers a safe and effective method for cosmetic local fat reduction from the waist.
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<strong>📄 Archived:</strong> 2025-08-09 22:40:33 UTC
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<strong>🔗 Source:</strong> <a href="https://tim.blog/2011/01/16/spot-reduction-revisited-removing-stubborn-thigh-fat/">https://tim.blog/2011/01/16/spot-reduction-revisited-removing-stubborn-thigh-fat/</a>
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<h1>Spot Reduction Revisited: Removing Stubborn Thigh Fat</h1>
<html><body><div><div class="entry-content wp-block-post-content has-global-padding is-layout-constrained wp-block-post-content-is-layout-constrained"><p><img data-recalc-dims="1" decoding="async" src="https://i0.wp.com/tim.blog/wp-content/uploads/2011/01/2542578931_62be900de4.jpg?ssl=1"/></p>
<p><small><strong>Is it possible to remove fat from specific areas of the body?</strong> (Photo of low-fat legs: <a href="http://www.flickr.com/photos/kirisryche/" rel="noopener noreferrer" target="_blank">Kirikiri</a>)</small></p>
<p><em>(Preface: This is one of the “bonus chapters” for <a href="http://www.amazon.com/gp/product/030746363X?ie=UTF8&amp;tag=offsitoftimfe-20&amp;linkCode=as2&amp;camp=1789&amp;creative=390957&amp;creativeASIN=030746363Xerehttp://www.amazon.com/gp/product/030746363X?ie=UTF8&amp;tag=offsitoftimfe-20&amp;linkCode=as2&amp;camp=1789&amp;creative=390957&amp;creativeASIN=030746363X" rel="noopener noreferrer" target="_blank">The 4-Hour Body</a>. My sincerest apologies for the confusion! <a href="https://www.fourhourworkweek.com/blog/4-hour-body-bonus-material-and-bonus-chapters/" rel="noopener noreferrer" target="_blank">All bonus materials can be found here</a>. Enjoy! New forums and more coming very soon…)</em></p>
<p><strong><em>I’m allergic to food. Every time I eat it breaks out into fat.</em></strong></p>
<p>—Jennifer Greene Duncan</p>
<p><em>Does History record any case in which the majority was right?</em></p>
<p>—Robert Heinlein</p>
<p>In the early 1900s, a 12-year-old girl burned the back of her hand. You are right: this is not newsworthy.</p>
<p>It’s what followed the burn, documented in the medical records, that fascinated me:</p>
<blockquote><p>Doctors used skin from her abdomen as a graft over the burn. By the time this girl turned thirty, she had grown fat, and the skin that had been transplanted to the back of her hand had grown fat as well. “A second operation was necessary for the removal of the big fat pads which had developed in the grafted skin,” explained the University of Vienna endocrinologist and geneticist Julius Bauer, “exactly as fatty tissue had developed in the skin of the lower part of the abdomen.”</p></blockquote>
<p>The plight of women and fat is the stuff of legend.</p>
<p>Female fat deposition in the legs and buttocks increases with age, as does abdominal fat and the so-called saddle bags—fat just beneath the hips—in perimenopausal and menopausal women.</p>
<p>How is it that women can eat peanut butter, for example, and seemingly bypass the stomach to put it directly on their asses? Why doesn’t this happen to men, who seem to put fat directly on their would-be six-pack, which ends up resembling more of a one-pack (or “six-pack in the cooler”), even if they have bodybuilder-like veins on their arms?</p>
<p>To paraphrase <a href="http://www.amazon.com/gp/product/0307272702?ie=UTF8&amp;tag=offsitoftimfe-20&amp;linkCode=as2&amp;camp=1789&amp;creative=390957&amp;creativeASIN=0307272702" rel="noopener noreferrer" target="_blank">Gary Taubes</a>: some biological factor must regulate this. One candidate is the A-2 receptor, and that is what I decided to look at for practical experimentation…<span id="more-4416"></span></p>
<p>The A-2 receptor, or alpha-2 andrenergic receptor, is the party spoiler when it comes to fat-loss in gender-specific problem areas. From the journal <em>Obesity Research</em> (bolding is mine):</p>
<blockquote><p>The fat on women’s thighs is more difficult to mobilize due to increased <strong>alpha-2 adrenergic receptor activity</strong> induced by estrogen. <strong>Lipolysis [fat-loss] can be initiated through</strong> adipocyte receptor stimulation (beta adrenergic) or<strong> inhibition (adenosine or alpha-2 adrenergic) or by inhibition of phosphodiesterase.</strong></p></blockquote>
<p>In plain Ingrish, this means that estrogen helps pesky fat-mongering A-2 receptors do their work, and there are three effective gambits for losing fat despite this.</p>
<p>For decades, the consensus among exercise professionals has been that<em> spot reduction</em>—reducing fat in one specific body area—is impossible, a myth. I long assumed this was the case until I asked the hypothetical question: if we assume there might be an effective mechanism for spot reduction, what would it look like if we focused on the three above pathways?</p>
<p>It seemed that one answer would be a topical lotion that inhibits the A-2 receptor or blocks phosphodiesterase (1). Another potent and supporting mechanism might be reducing the availability of cortisol at the level of the fat cells themselves (2).</p>
<p>Guess what? There are compounds that can be used for either: aminophylline for the former and glycyrrhetinic acid for the latter.</p>
<p>The two are quite different. Aminophylline is a bronchodilator used for asthma that contains theophylline, a stimulant found in tea that is similar to caffeine. Glycyrrhetinic acid, on the other hand, prevents the breakdown of specific prostaglandins (PGE-2 and PGF-2a) and is derived from licorice; it can be used as a base for expectorants or even artificial sweeteners.</p>
<p>Fat-loss is an off-label use for the latter in particular, but clinical studies indicate that both can selectively reduce thigh fat in females and males when applied as a cream.</p>
<p>During the process of researching this book, I saw firsthand the empirical evidence of spot reduction with low-dose, high-frequency injections of human growth hormone (HGH), but the potential legal ramifications and side effects (like bone and organ growth) make HGH unattractive. If you see bodybuilders with distended abdomens that make them look like they’re nine months pregnant, you’ve probably seen drug-induced visceral organ growth. It’s not a look I recommend.</p>
<p>I’d also experimented on three occasions with converting yohimbine HCL into a topical cream based on the writing of Dan Duchaine, but the side effects, including excessive salivation (thank you, autonomous nervous system), weren’t worth the negligible fat-loss.</p>
<p>Feeling like a Pavlovian dog about to vomit is no way to spend your life, and abs won’t help your sex appeal if you’re drooling on yourself.</p>
<h3>It Rubs the Lotion on Its Skin</h3>
<p>I took a nine-year hiatus from experimenting with spot reduction, until <a href="http://www.amazon.com/gp/product/030746363X?ie=UTF8&amp;tag=offsitoftimfe-20&amp;linkCode=as2&amp;camp=1789&amp;creative=390957&amp;creativeASIN=030746363Xerehttp://www.amazon.com/gp/product/030746363X?ie=UTF8&amp;tag=offsitoftimfe-20&amp;linkCode=as2&amp;camp=1789&amp;creative=390957&amp;creativeASIN=030746363X" rel="noopener noreferrer" target="_blank">The 4-Hour Body</a> gave me the excuse to fuss with it again.</p>
<p>The research led me to aminophylline and glycyrrhetinic acid. All that remained was to get my hands on both, which I did.</p>
<p>The easiest-to-purchase source of a 2% aminophylline cream was the extremely scammy-sounding Celluthin™, which I ordered on Amazon.</p>
<p>Glycyrrhetinic acid was much harder to locate, as I could only find it through prescription as Atopiclair™, which is used for dermatitis and has a single U.S. distributor in Tennessee, Graceway Pharmaceuticals LLC. Even with prescription-writing doctors willing to indulge me, Graceway made it almost impossible to find the product details and prescribing information for dosing. The latter is needed to write a “script,” of course. Eventually we ferreted it out of some subpage on the website, and I was able to fill candidate B at a local Walgreen’s within 48 hours.</p>
<p>Celluthin cost $49.99, and Atopiclair topped out at more than $100.</p>
<p>Here’s what happened. We’ll look at the prescription drug first, for reasons that will become clear.</p>
<h3>The Results</h3>
<p><strong>Glycyrrhetinic Acid Cream (Atopiclair®)</strong></p>
<p><strong>FIRST, A WARNING FOR WOMEN:</strong> Glycyrrhetinic acid inhibits the breakdown of several prostaglandins, including PGF-2a, which therefore increases their levels. Since PGF-2a is known to stimulate uterine activity during pregnancy and can cause miscarriage, glycyrrhetinic acid should not be taken by those who are pregnant or attempting to become pregnant.</p>
<p>I applied Atopiclair thrice daily—upon waking, again at 5:00 P.M., and again before bed—for 13 days. I believe both the effects and potential side effects would have been even more pronounced for a woman:</p>
<p><strong>Before (November 10, 2009) and After (November 23, 2009)</strong></p>
<p>Treated right chest: 5 mm –&gt; 4.43 mm (-.57 mm)</p>
<p>Untreated left chest: 5 mm –&gt; 5.5 mm (+.5 mm)</p>
<p>All measurements were taken at least three times and then averaged. For example, the first “5mm” was derived from readings of 4.9, 5.0, and 5.1 millimeters. But back to our story…</p>
<p>To account for systemic changes, such as diet-induced fat loss or gain, and to create a control, I treated only the right side of my chest on the upper torso. Sites were as far apart as possible and therefore near the armpits.</p>
<p>I lost more than 10% total fat on the treated side and gained exactly 10% on the untreated side. These measurements were clear, and the fat gain on the untreated area made sense, as I was in an overfeeding phase.</p>
<p>The next set of measurements, however, were confusing.</p>
<p>Treated right abdominal: 7.0 mm –&gt; 5.93 mm (-1.07 mm)</p>
<p>Untreated left abdominal: 6.3 mm –&gt; 5.13 mm (-1.17 mm)</p>
<p>The abdominal area I measured is the mid-tier of the six-pack, the second “bump” up from the bottom in the rectus abdominus, or the first “bump” above the navel. I chose this area instead of the usual one inch to either side of the navel because it produced more consistent readings with the ultrasound device I used (4).</p>
<p>You read the data right: though I lost fat on both sides, I lost <em>more</em> fat on the <em>untreated</em> side. No matter how many times I repeated the measurements, that was the conclusion.</p>
<p>Huh?</p>
<p>I have no explanation, other than a possible crossover effect from the topical application, as the measured areas were separated by no more than one inch. I knew this would be a risk—hence the decision to measure the opposing sides of the chest as well.</p>
<p>Can we reconcile the apparent benefit on the chest and the conflicting data from the abs? Not with this alone. There is really only one solution: repeat the test.</p>
<p>Fortunately, our other candidate gave much clearer results.</p>
<p><strong>Aminophylline Cream</strong></p>
<p>Celluthin™ has the following ingredients listed on the label in (assuming this was done as the FTC requires) descending order of volume:</p>
<p>Purified water, Aminophylline, Yerbe Matte, Coleus Forskohli Extract, Oil of Peppermint, Carbomer, Triethanslamide, Liposomes, Butylparaben, Isobutylparaben, Isopropylparaben, Phenoxyethanol, D &amp; C Red #28</p>
<p>I was particularly impressed with the misspellings of both “yerba mate” and “coleus forskohlii.” Needless to say, I did not expect this product to have an effect, and I couldn’t find clinical support for topical spot reduction use of the ingredients besides aminophylline.</p>
<p>I used the product twice daily on my right thigh only, upon waking and before sleep, for 18 days.</p>
<p><strong>Before (October 12, 2009) and After (October 30, 2009) Measurements:</strong></p>
<p>Treated right thigh midline, six inches above kneecap upper limit: 8.1 mm –&gt; 7.4 mm5 (-0.7)</p>
<p>Untreated left thigh (same measurement): 7.9 mm –&gt; 7.8 mm6 (-0.1)</p>
<p>On the treatment thigh, I lost 8.64% of my fat thickness, as opposed to a 1.26% loss on the control leg. Even more incredible was the apparent persistence of effect after cessation of use.</p>
<p><strong>Here are the same measurements 11 days after I stopped application of the cream:</strong></p>
<p>Right thigh: 7 mm (additional 5.71% reduction, or 0.4 mm)</p>
<p>Left thigh: 8.3 mm (a gain of 0.3 mm)</p>
<p>In other words, even though I was in an overeating phase and gained fat on my left thigh (0.3 millimeters), I continued to lose fat, almost an additional 6%, on the right thigh, which had been previously treated. I didn’t believe this outcome and remeasured the sites three times, but the data were consistent.</p>
<p>Consider me a believer.</p>
<p>Based on my experience, using a 2% aminophylline cream for two and a half weeks, applied twice daily, accelerates thigh fat-loss more than 10 times compared to a control.</p>
<p>I’ll leave the Atopiclair to the dermatitis sufferers.</p>
<h3>Tools and Tricks</h3>
<p><strong>Celluthin</strong> – The topical lotion containing aminophylline that effectively inhibits the A-2 receptor. Use carefully, as it appears to continue to inhibit this receptor for at least several days after you’ve stopped using it.</p>
<p><a href="http://www.amazon.com/Celluthin-Topical-Cellulite-Reducing-Aminophylline/dp/B003N8H586/" rel="noopener noreferrer" target="_blank">Non-affiliate Amazon link</a></p>
<p><a href="http://www.amazon.com/gp/product/B003N8H586?ie=UTF8&amp;tag=offsitoftimfe-20&amp;linkCode=as2&amp;camp=1789&amp;creative=390957&amp;creativeASIN=B003N8H586" rel="noopener noreferrer" target="_blank">Affiliate Amazon link (I get a small commission)</a></p>
<p><strong>Atopiclair (Glycyrrhetinic Acid Cream) (<a href="http://www.atopiclairus.com" rel="noopener noreferrer" target="_blank">www.atopiclairus.com</a>)</strong>. Here’s where you can find more information about Atopiclair. You won’t be able to order the product directly, but you can get rebates on the official site if you decide to apply for a prescription.</p>
<p><strong>Footnotes and References:</strong></p>
<p>1 – This increases cAMP, which facilitates catecholamine stimulation of lipolysis.</p>
<p>2 – Via inhibition of 11beta-hydroxysteroid dehydrogenase type 1.</p>
<p>3 – All measurements were taken at least three times and averaged, in this case from</p>
<p>readings of 4.9, 5.0, and 5.1 millimeters.</p>
<p>4 – Using ultrasound higher than the standard abdominal point, the ultrasound echo</p>
<p>from the fascia (connective tissue) layer can get weaker, which reduces the risk of</p>
<p>the software switching between the fascia and the true fat-muscle interface.</p>
<p>5 – Averaged from measurements of 7.0, 7.3, 7.4, and 7.5 millimeters.</p>
<p>6 – Averaged from measurements of 8.0, 7.8, and 7.8 millimeters.</p>
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<h1>Is Rib Reshaping Better Than Rib Removal For Waistline Narrowing?</h1>
<html><body><div><div class="content-wrap-text"><p><span>Q: Dr. Eppley, I was reading an article by a male to female transgender woman who mentioned having a procedure in Mexico where the doctor broke her lower ribs and wrapped them tightly so that they would fuse together in a more narrow position. I am a slim young woman who would like a more narrow rib cage to give me a longer more narrow waist, but would like to keep my ribs if at all possible. I assume this would be called “rib manipulation” since it is the controlled breaking of the lower ribs. Have you heard of this being done for cosmetic purposes and can you give me information on the pros and cons of this procedure?</span></p><p><a href="http://eppleyplasticsurgery.com//wp-content/uploads/2014/06/Rib-Removal-Surgery-Dr-Barry-Eppley-Indianapolis.jpeg"><img alt="Rib Removal Surgery Dr Barry Eppley Indianapolis" class="alignnone size-thumbnail wp-image-13547 native-lazyload-js-fallback" data-src="http://eppleyplasticsurgery.com//wp-content/uploads/2014/06/Rib-Removal-Surgery-Dr-Barry-Eppley-Indianapolis-150x150.jpeg" decoding="async" loading="lazy" src="https://www.eppleyplasticsurgery.com/wp-content/plugins/native-lazyload/assets/images/placeholder.svg"/><noscript><img alt="Rib Removal Surgery Dr Barry Eppley Indianapolis" class="alignnone size-thumbnail wp-image-13547" decoding="async" loading="lazy" src="http://eppleyplasticsurgery.com//wp-content/uploads/2014/06/Rib-Removal-Surgery-Dr-Barry-Eppley-Indianapolis-150x150.jpeg"/></noscript></a>A: What you are referring to would be known as rib reshaping by osteotomies as opposed to the more traditional rib removal procedure to make a more narrow rib cage. The rib as it extends from the spine and around the side of the body is composed of bone (from the spine out to about halfway around the side of the body) and then becomes softer cartilage as it extends to join the sternum. (ribs 10 through 12, also known as the ‘free floaters’ do not extend to the sternum…which turns out to be a very important point in this discussion) If the rib is osteotomized (cut) at the bone-cartilage junction, the cartilaginous end would be more bendable and theoretically could be molded inward as it heals for a more narrow waistline with after surgery binding. This would only apply to the free floating ribs which do not have an attached end. It would not work for any higher ribs because they have a complete arc around the body with a fixed point to the sternum.</p><p>The advantages to rib reshaping is that it would be less invasive since the ribs are not being removed, would have an easier recovery, may be able to be be done with a smaller incision on each side and would preserve the ribs. The disadvantages is that it is not really clear if it would really work and could be a source of chronic pain if the separated rib area do not heal. (osteochondritis)</p><p>Dr. Barry Eppley</p><p>Indianapolis, Indiana</p></div></div></body></html>