From 44486903268b5b4649a47399e287d6af5eb42d7f Mon Sep 17 00:00:00 2001 From: jorts Date: Wed, 6 Aug 2025 18:43:34 +0100 Subject: [PATCH] updated files --- docs/index.md | 113 ++++++------- ...soyct-github-io__index-html__2a460b067b.md | 150 ------------------ mkdocs.yml | 4 +- 3 files changed, 59 insertions(+), 208 deletions(-) delete mode 100644 docs/sources/ihsoyct-github-io__index-html__2a460b067b.md diff --git a/docs/index.md b/docs/index.md index 7dc06be..0b5117e 100644 --- a/docs/index.md +++ b/docs/index.md @@ -1,10 +1,11 @@ + # Wiki of Dark Arts -# HRT +## HRT there is plenty of info on E and AAs and the like online. Info can be added here, but I am interested in very niche things here. -# Weight Cycling +## Weight Cycling The process of repetitively gaining and subsequently losing weight. @@ -17,29 +18,29 @@ Links: * [Mesityl - MTF Weight Cycling](https://mesityl.substack.com/p/mtf-weight-cycling){ .source-link } * A good introduction on the topic, covers many of the things below, has more sources cited, and also discusses some things to avoid. -## Downcycle +### Downcycle In the down cycle, the aim is to have a caloric deficit, and hopefully pull more fat from "undesired places" rather than from relatively desireable places. -## Maintining a caloric deficit +### Maintining a caloric deficit Depending on the person, it may be difficult to keep a caloric deficit. There are some things that can help with this: -## Caloric Deficit through Diets +### Caloric Deficit through Diets - different diets seem to work for different people. todo: add more detail -## Caloric Defficit with assistance of supplements +### Caloric Defficit with assistance of supplements -### Water-soluble fibres +#### Water-soluble fibres such as Psyllium Husk or Glucomannan are effective at filling up the stomach/digestive tract and promoting a feeling of fullness, reducing appetite and promoting weight loss. -### GLP-1 Agonists +#### GLP-1 Agonists There are various GLP-1 receptor agonists drugs like semaglutide, liraglutide, dulaglutide, exenatide, and tirzepatide. These promote weight loss through increasing insulin release, decreasing insulin resistance and decreasing excessive glucagon release. Their biggest downsides include very high price and the only viable RoA being injection. -## Burning the right fat +### Down cyle - Burning the right fat -### Aminophylline +#### Aminophylline [Link to Meta-analysis](https://pmc.ncbi.nlm.nih.gov/articles/PMC9978326/){ .source-link } @@ -49,43 +50,42 @@ In particular, one study on 25 men/women, when on a 1200kcal diet, achieved a re However, there is almost no discussion of this online. -### Transdermal Caffeine +#### Transdermal Caffeine Transdermal caffein -### Waist-training +#### Waist-training As another option, if looking particularly to improve WHR or get a more hour-glass figure, could be waist training. This can often reduce appetite while worn. If done correctly this is usually quite safe, thought this does often cause the floating ribs 8-12 to shift inwards, and may cause some organs to move around. -### Dangerous Darth Method +#### Dangerous Darth Method This is a subtype of "waist training". This method, labelled dangerous, by darth, involves following practices that are actively reccomended against in the FtM community when binding. may cause pain, costochondritis, cracked or fractured ribs, reduced lung capacity, lung or kidney damage from floating ribs etc. [Darth Method Writeup](https://old.reddit.com/r/estrogel/comments/iod975/unrelated_darth_dangerous_experiments_diy_shrink/){ .source-link } -### Selective Muscle training +#### Selective Muscle training Strength training of specific muscles (e.g. the abdominals) prior to endurance training (e.g. a long cardio session) might be able to selectively burn fat in the corresponding area – this could be useful when trying to achieve a lower WHR. -### Acetyl-l-carnitine (ALCAR) +#### Acetyl-l-carnitine (ALCAR) is an orally bioavailable form of carnitine which is involved in the carnitine shuttle and is vital to fat metabolism. Supplementation has been shown to improve rates of fat metabolism and weight loss. -### Other things NOT worth considering: +#### Other things NOT worth considering: -## The upcycle +### The Upcycle - Growing the right fat -In a way opposite to downcycling, weight gain is achieved when your calorific intake is higher than your total daily energy expenditure (TDEE). This does not mean no exercise or junk food as both of these would have an adverse health effect. In my personal experience upcycling can be even more mentally straining than downcycling – the feeling of guilt from purposefully eating large quantities of food or dysphoria felt from weight gain/tummy bloat is indeed unpleasant. The most important thing to remember is that these are all temporary and will help you achieve an ultimately better body in the long term! +Gaining weight, with the hope that it grows in the "right places" - -### Weight gain supplements +#### Weight gain supplements Just like with downcycling, there are a range of supplements that could be used to aid your upcycle… -### Pioglitazone +#### Pioglitazone "pio" is an anti-diabetic medication that activates PPAR-gamma systemically, reducing insulin resistance, gluconeogenesis and overall blood sugar. High insulin resistance in transgender females is associated with android fat distribution/higher WHR. It has been shown to lower visceral fat and WHR even in patients who’s overall BMI remained the same. It seems to protect subcutaneous fat in a way similar to estrogen. There has even been one documented case of pioglitazone use to achieve female fat distribution in a transgender patient in the medical literature. The drug would probably be beneficial regardless of whether you are cycling or not. @@ -97,7 +97,7 @@ It has been associated with some risks to kidneys, but for short-term use it sho Typically people take it orally, but there are some reports of taking it topically: * [Topical Pio + AH38](https://old.reddit.com/r/DIYCosmeticProcedures/comments/1g4v3wp/topical_pioglitazone_ah38_for_lost_volume/){.source-link} -## Acetyl-Hexapeptide-38 (Adifyline®) +#### Acetyl-Hexapeptide-38 (Adifyline®) Adifyline®, topically applied increases PGC-1α expression, stimulating adipogenesis and lipid accumulation as a consequence67 (in a way opposite to hexapeptide-39). Again, the local effect of the drug could be leveraged to selectively increase fat in certain areas and thus improve WHR/fat distribution. In general, reports are pretty hit-or-miss, unclear if due to application method differences or genetic differences or both. There is like, one study on it: @@ -115,7 +115,7 @@ Typical place to buy is on LotionCrafters: * [lotioncrafters](https://lotioncrafter.com/collections/active-ingredients/products/adifyline) -### Acetyl-Hexapeptide-39 (Silusyne®) +#### Acetyl-Hexapeptide-39 (Silusyne®) topically applied decreases PGC-1α expression, diminishing adipogenesis and lipid accumulation as a consequence. It could potentially be used topically to selectively reduce fat accumulation in certain areas and thus improve WHR/fat distribution. @@ -124,7 +124,7 @@ However, there is, in general, very little literature on this. The [Mesityl - MTF Weight Cycling](https://mesityl.substack.com/p/mtf-weight-cycling){ .source-link } post has some discussion on this, and implies that it would work for the down cycle, though it could also make sense for the up cycle to inhibit growth in certain areas. -### Volufiline +#### Volufiline Volufiline is a patented cosmetic preparation containing Sarsapogenin which has been reported to stimulate adipocytic differentiation and adipogenesis by activation of PPAR-gamma. Similarly to the hexapeptide-38, it can be applied topically and perhaps even used synergistically. @@ -133,18 +133,24 @@ Volufiline is a patented cosmetic preparation containing Sarsapogenin which has Some recommend buying sarsapogenin directly: * [Reddit post on buying sarasapogenin](https://old.reddit.com/r/estrogel/comments/1bodb0k/dont_waste_money_on_volufiline_get_the_raw/){.source-link} -### CJC-1295 +#### Leucine and Argenine +Leucine and Argenine have been shown to be particularly effective at activating mTOR, a kinase that stimulates lipid synthesis and cell growth. + + +### Other chemicals + +#### CJC-1295 CJC-1295 DAC, also known as DAC:GRF, is a synthetic peptide analogue of growth hormone-releasing hormone and a growth hormone secretagogue. It is a modified form of GHRH with improved pharmacokinetics, especially in regard to half-life. - [article about it](https://allaboutpeptides.com/cjc-1295-peptide/){.source-link} - [post about it on Reddit](https://old.reddit.com/r/DrWillPowers/comments/uh22mo/cjc1295_wdac_effect_on_breast_growth_and_surgery/){.source-link} -### ipamorelin +#### ipamorelin Ipamorelin is a peptide selective agonist of the ghrelin/growth hormone secretagogue receptor and a growth hormone secretagogue. It is a pentapeptide with the amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂ that was derived from GHRP-1. Ipamorelin significantly increases plasma growth hormone levels in both animals and humans. In addition, ipamorelin stimulates body weight gain in animals -### tesmorelin +#### tesmorelin Tesamorelin is a synthetic hormone used to reduce excess abdominal fat in adults with HIV-associated lipodystrophy. It is administered via subcutaneous injection and requires a prescription from a doctor. @@ -152,14 +158,14 @@ I have seen one report of someone injecting 6/3/3mg mix of tesmorelin/cjc1295/ip > The cjc1295, I inject into belly fat, a 6/3/3mg mix of tesmorelin/cjc1295/ipamorelin vial. A few minutes after the injection, I can feel a headrush, and any soreness recovery from exercise appears to happen within hours, however there may be soreness in the breasts from tissues expanding. -### igf-1 DES +#### igf-1 DES Des(1-3)IGF-1 is a truncated form of insulin-like growth factor 1 (IGF-1) that has enhanced potency compared to IGF-1 due to its reduced binding to insulin-like growth factor-binding proteins. It is used in research and has potential therapeutic applications, particularly in growth-related conditions > I inject the igf-1 DES in the right breast area as the lymphatic system drains into the left side if I understand it correctly. The DES modification of igf-1 is very potent and activates all the growth receptors, including insulin receptors. The half life isn't very long, but the effect is noticable. About 0.05mL at a time, twice a day, from a 2mL of bacteriostatic water in a 1mg igf-1 DES vial. -### kisspeptin +#### kisspeptin Kisspeptin stimulates production of GnRH, FSH and LH and is much cheaper than (prescription-only) injectable FSH (follitropin). Can lead to additional breast growth. @@ -179,50 +185,45 @@ Example dosage: Link to article about it: -# Leucine and Argenine -Leucine and Argenine have been shown to be particularly effective at activating mTOR, a kinase that stimulates lipid synthesis and cell growth. +### Things to Avoid - - -## Things to Avoid - -### Alcohol Consumption +#### Alcohol Consumption Moderate alcohol consumption increases abdominal fat, worsening fat distribution, and increases plasma androgens in cisgender females. Therefore it is highly discouraged. -# Face +## Face -### Suncream +#### Suncream Most obvious, shuldn't even need to say it, but do apply suncream to face every day. -### Retinoids +#### Retinoids Retinol (weak) and Tretinoin (strong) -### Red light therapy +#### Red light therapy Some early results says it helps. -### Other things +#### Other things Hylauranic acids, Niacinamide, Vitamin C, Glycolic Acids, etc... probably help and combine to have a good effect, but not as huge an effect. -### Volume +#### Volume apart from HRT, look at Adyfiline, Volufiline, and such. See above. -# Hair +## Hair -## General care +### General care -### Fringe +#### Fringe A common strategy in the MtF trans community to "improve shaping of the face" is to get a fringe. -### Better hair care and styling +#### Better hair care and styling Looking after your hair in the right way can make it look a lot better. I am a non-expert on this, but things that help me: @@ -234,33 +235,33 @@ Mistakes I have made: Other people will have different tips, so please add if you have some. -## Prevent loss / regain growth +### Prevent loss / regain growth -### Finasteride / Dutasteride +#### Finasteride / Dutasteride Decreases DHT levels to prevent hair loss (NOT an anti-androgen) and is associated with mental health effects. See other websites for this, these are common. -### Minoxidil +#### Minoxidil Promotes hair growth. See other website for this, also quite common. (or someone else please update this) -### Estrogen (without feminization) +#### Estrogen (without feminization) > try to wash your face 5 minutes after applying [5 mg/ml estriol serum]: this will only allow the shunt pathway (ie through hair follicules) maximizing the effect on follicules and therefore the pores, without allowing normal transdermal absorption > this method is used by men using E2 to regrow hair without systemic side effects (like boobs) and is supported by papers I read (search the sub for the shunt pathway) I haven't looked much at this. See [comment in this unrelated reddit post](https://old.reddit.com/r/estrogel/comments/1bodb0k/dont_waste_money_on_volufiline_get_the_raw/){.source-link} -### Hair Transplant +#### Hair Transplant Todo: add more info here. -# Breast Growth +## Breast Growth -### Adifyline +#### Adifyline See section above -### Progesterone +#### Progesterone > 1. Injectable progesterone is short-acting, must be injected daily. > Oral progesterone is ineffective because most of it is converted to allopregnanolone which common blood tests confuse with progesterone. @@ -284,8 +285,8 @@ See section above > Or never take progestogens. In cases of complete androgen insensitivity (CAIS), > XY women develop rather spectacularly feminine secondary sexual characteristics though nothing in their bodies makes progesterone. -### Other +#### Other -# Contributing +## Contributing To contibute, make an issue on git \ No newline at end of file diff --git a/docs/sources/ihsoyct-github-io__index-html__2a460b067b.md b/docs/sources/ihsoyct-github-io__index-html__2a460b067b.md deleted file mode 100644 index d415300..0000000 --- a/docs/sources/ihsoyct-github-io__index-html__2a460b067b.md +++ /dev/null @@ -1,150 +0,0 @@ -*Archived 2025-08-06 17:14 UTC from https://ihsoyct.github.io/index.html?backend=artic_shift&mode=comments&author=Gloomy-Scarcity-2197&limit=100&sort=desc&body=adifyline* - -# Comments by u/Gloomy-Scarcity-2197 • containing 'adifyline' - -**/r/DIYaesthetics/comments/1gt4n3m/adifyline_purchasingvolume_guide/mkkr7so/** -https://reddit.com/r/DIYaesthetics/comments/1gt4n3m/adifyline_purchasingvolume_guide/mkkr7so/ - -u/Gloomy-Scarcity-2197 • 1 points • 2025-03-30 20:28 UTC • r/DIYaesthetics - -Good in both myself and my partner. She was lacking fat development more than I was and she saw visible increases in a month of usage in both face and breasts. Not dream-result, but significant. - -I saw smaller but still perceptible changes. The biggest difference was on the backs of my hands. - -We're both trans-feminine and I'm on the chunk side while she's skinny. - -I ended up using LotionCrafter as it comes a little bit more finished than AliBaba. Mixed 1ml of Adifyline with 1ml of Vasoline Cocoa Glow (mixing up about 20ml at a time). Applied to face, breasts and any leftovers to backs of hands. - ---- - -**/r/45PlusSkincare/comments/1j3t3rt/what_can_i_do_next_routine_in_comments/mg2yz6d/** -https://reddit.com/r/45PlusSkincare/comments/1j3t3rt/what_can_i_do_next_routine_in_comments/mg2yz6d/ - -u/Gloomy-Scarcity-2197 • 1 points • 2025-03-05 02:55 UTC • r/45PlusSkincare - -These photos are only about a month apart. The big change is I actually started sticking to my routine instead of once a fortnight. - -I also let ChatGPT's research mode pair up skincare products with some of my medications and other goals. It may have been overkill but I actually understand what everything is doing now and have some plans to expand it. It also reminds me morning and night what I need to do :) - -The biggest practical change seems to be that my skin is healing and thickening resulting in a more even colour tone. - -Morning - -* Cleanse with Garnier PureActive -* Adifyline -* The Ordinary Multi-peptides with copper (this is new) -* The Ordinary Hyaluronic acid -* The Ordinary Vitamin C suspension 23% with HA spheres (this is new) -* The Ordinary Niacinamide -* Moisturise with Vasoline Cocoa Glow -* La Roche-Posay Antihelios if I'm going outside or will be in the sun at all - -Night - -* Cleanse -* Adifyline -* Multi-peptide -* Tretinoin -* Moisturise - -I'm planning on getting a Derminator soon, and I'm also thinking about DMSO+Tret for areas of body skin that are too thick to achieve any structural changes. - -At some point I'll also try out C60 Buckyballs as they seem to be anti-aging magic or something. - -My main peeve at the moment is something the photo didn't manage to capture - there's tiny soft freckles all over my face but they're not distinct enough to be freckles so I just kind of look not washed in the wrong light. Any other suggestions on how to handle that? - ---- - -**/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mc2nlb1/** -https://reddit.com/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mc2nlb1/ - -u/Gloomy-Scarcity-2197 • 2 points • 2025-02-10 20:29 UTC • r/45PlusSkincare - ->I'll be retesting with the tret soon so that's that covered. - -You can't "test" this stuff any more than you already have. Either you commit to using it for the required period to actually see a difference or don't bother I guess. You won't see decent results until you've used it for a couple of years consistently. - ->The adifyline I'll test on the cheeks and may be around the forehead then see how it's going. - -That isn't how that works either unfortunately. Your face will absorb it and it'll put the fat where your genetics said you should have had it as a teenager. The good news is that's everywhere that makes you look healthy and young. - ---- - -**/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbyhh71/** -https://reddit.com/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbyhh71/ - -u/Gloomy-Scarcity-2197 • 1 points • 2025-02-10 03:25 UTC • r/45PlusSkincare - -Now we're talking. - -How long ago did you lose the weight? This looks like classic ozempic (or any other rapid weight loss) face. It takes a couple of years but your skin will tighten up in certain ways. Tret helps that happen faster (skin cell cycling + adds a ton of fresh collagen and elastin). - -For the rest, you can definitely look at adifyline to cover some bases as well. - -As I've said a few times, no single thing is the entire solution, but each thing gets you noticeably closer. As long as you're not expecting magic, it can happen. - -As you're a cis man, I'd also probably add a weak estrogen topical cream to that, but you need to be *very* careful here, as yes, misuse or not understanding dosages can cause breast buds to develop and not just softer skin. r/drwillpowers has mentioned his personal concoction a few times, and you can buy your own Estradiol Valerate from grey-market sites and carefully make your own lotion. - ---- - -**/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbwimqr/** -https://reddit.com/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbwimqr/ - -u/Gloomy-Scarcity-2197 • 2 points • 2025-02-09 21:00 UTC • r/45PlusSkincare - -My weight moved around rather than losing any. Estrogen definitely helped in that regard, and it's known for seeming to wind back age a bit, but it's not nearly as effective in that regard as adifyline, with the main bonus being adifyline doesn't make you become a woman if you're a cis-gendered man. - -There's about ten major factors in everyone's age appearance rather than just one or two. - -I'm just hitting that age where I *should* be showing signs of aging and I've carefully addressed all of the sub-issues. Estrogen is just one of the things I had available to me. - -Given that adifyline is relatively cheap, and topical (so it's easy and non-invasive to use) and *fast* I'd always say try that for a couple of months first. - ---- - -**/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbr6821/** -https://reddit.com/r/45PlusSkincare/comments/1ijzb9h/help_i_think_tretinoin_is_creating_lines_wrinkles/mbr6821/ - -u/Gloomy-Scarcity-2197 • 2 points • 2025-02-09 00:32 UTC • r/45PlusSkincare - -I mean, time matters. Start everything you should be doing NOW. - -Tret is the minimum, so it's good you're doing it, but there are other options you can try too. - -In the end, men age with a fair amount of dignity and you seem to be doing really well. I don't see any real negatives going on here, but if you MUST look young, search reddit or my post history for Adifyline. - ---- - -**/r/45PlusSkincare/comments/1ijlh6h/estradiol_vaginal_cream/mblzglu/** -https://reddit.com/r/45PlusSkincare/comments/1ijlh6h/estradiol_vaginal_cream/mblzglu/ - -u/Gloomy-Scarcity-2197 • 3 points • 2025-02-08 04:53 UTC • r/45PlusSkincare - -My experience has been that if you already have estrogen in your system, this won't really help much. - -I have heard of men using a weak estradiol face cream to some effect, but if you have any amount of estrogen in you at all you're probably already getting the full benefit of it. - -It's a little new, but look into acetyl hexapeptide-38 (also known as adifyline) as a topical treatment for what you're trying to do. I used my hands to apply it to my face and after about a month both showed pretty good improvement. This peptide likes to stimulate fat rejuvenation in places that juvenile humans normally only have it, and it winds the clock back pretty good in some aspects like sagging and overall wrinkling from slack skin. - ---- - -**/r/45PlusSkincare/comments/1h5i4kv/is_there_anything_i_should_work_on_47f/m08q41q/** -https://reddit.com/r/45PlusSkincare/comments/1h5i4kv/is_there_anything_i_should_work_on_47f/m08q41q/ - -u/Gloomy-Scarcity-2197 • 1 points • 2024-12-03 18:52 UTC • r/45PlusSkincare - -Adifyline from lotioncrafter - ---- - -**/r/45PlusSkincare/comments/1h5i4kv/is_there_anything_i_should_work_on_47f/m08q1xl/** -https://reddit.com/r/45PlusSkincare/comments/1h5i4kv/is_there_anything_i_should_work_on_47f/m08q1xl/ - -u/Gloomy-Scarcity-2197 • 2 points • 2024-12-03 18:51 UTC • r/45PlusSkincare - -Lotioncrafter sell it. I mix it with 1 pump of moisturiser to every 1ml of serum and apply the same amount to each region I'm treating morning and night (apparently it also causes breast plumping so I use it there as well). - -On their site it's called adifyline. I searched around for clinical studies and only found one. - ---- - diff --git a/mkdocs.yml b/mkdocs.yml index 3ebdfb2..a5e6a9d 100644 --- a/mkdocs.yml +++ b/mkdocs.yml @@ -1,5 +1,5 @@ -site_name: Ring-Making Mega-Guide -site_url: https://docs.example.com +site_name: Wiki of Dark Arts +site_url: https://wikiofdark.art/ theme: name: material