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+r/AskWomenOver60 • by u/[deleted] • 1040 points
+[deleted]
+To me, your legs look fine. If you are self-conscious, that Sally Hanson AirBrush Legs is supercheap (I have had the same can for like three years) and it is water resistant.
+I don't actually us it on my legs but it's the only face makeup I've used for the last ten years. I put a blob of lotion or moisturizer in my palm and spray some of this into it and rub it over my face.
+Instant completely translucent tan that looks completely natural (nothing like self-tanner). it is great on days when you didn't get enough sleep the night before or are feeling peaky. My skin's pretty good from a lifetime of Retin A use but when I use this stuff, nonstop compliments on my skin-tone.
+Unless you are spraying it on directly, even if you are very fair, buy the Deep Glow Shade because you can dilute as you see fit by adding more moisturizer. It stays on forever mixed with lotion, doesn't settle in fine creases or emphasize flakiness (which is a concern for me as I've pretty much nonstop used Retin A since I was in my teens).
+Here is the Walmart listing, two cans of deep glow color for $19.94 (you can probably by them single in the store): https://www.walmart.com/ip/seort/10322901 Amazon has it too but $15.91 for one can is super high price. (I still have my Prime account because I get it half price but very nearly boycotting Amazon). That said, the can lasts super long if you spray it into a hand full of moisturizer instead of spraying it directly on your body.
+I only use this stuff on my face and neck because I am perfectly fine, at 67, with my legs looking shaggy -- it is expected. But, I can make one more recommendation if your gams really bother you.
+Back in the 90s when I worked for newspapers, a friend in the office lived near a compound pharmacy and had them mix up 16 oz tubs of 3% (or maybe 4%) aminophylline cream. (It's the asthma medication that was used in thigh creams of the era).
+Anyway, the percentage used matched the percentage employed in clinical trials.
+And this stuff worked! Within a few weeks, completely changed the texture of our butts and thighs to baby smooth.
+(Unlike the ready made stuff which came in three or four ounce tubes and should have worked if aminophylline was present in the quantity claimed on the label, but it didn't work.
+In any event, none of the aminophylline containing thigh creams on the market today are full strength and regulatory agencies have even fewer teeth so I wouldn't waste my money trying them.
+But ... if you want to give it a try, find a a compound pharmacy and get a quote for how much they'd charge for a pound of basic white cream with 4% aminophylline in it.
+(In the 90s, NYC, it was $100 for a one-pound jar but considering it was big enough to last six months it wasn't a horrible deal).
+And if you find a good compound pharmacy, please report back and let us know!
+Note: if it works, you will absolutely notice. It is not like a lot of supplements and topicals in the sense that the difference is super-obvious. You don't have to surmise whether you are getting a placebo effect to justify expenditure.
+I am much broker now then I was then -- plus I have packed it in, perhaps permanently, in terms of dating -- but I would nevertheless consider a purchase like this if I met a great woman (definitely done with men, no offense intended).
+Never been one of those women who claims she wears makeup, high heels, hair coloring etc. "for myself." For me, for being among friends and family, I don't give a damn.
+But I can frame grooming in my own mind as a kind of "mating ritual" -- I mean, I have always hated perfumes, no matter how fine, but if a partner is super into scent and it it makes her more eager, I learn to cope.
+PS: OP, you realize that you shot your legs from an angle nobody but you will ever view! Guarantee you will like them infinitely better if you check yourself out in full length mirror in full sunlight.
+This is a super interesting and helpful comment, thank you!
+r/SkincareAddiction • by u/brasscup • 0 points
+Amazon products don't cut it and are absurdly expensive per fluid oz. Back in the 90s when they first started saying aminophylline cream reduced the appearance of cellulite, I lived in NYC and a friend would go to a compounding pharmacy where she had an existing relationship.
+They made her a basic cold cream type mix with a minimum of 3.5 per cent aminophylline as per clinical trials at a cost of $100 per 16 oz jar -- all of us in the office kept buying it for as long as we worked there... the results were incredible. Forget about cellulite -- not only was it smoother looking but the skin on our legs and butts was infant soft after a few weeks of use. Now I'm a gazillion years old, much poorer and longing for something similarly effective that I could afford for my droopy face.
+The lower part of my face and under jaw is where the fat from my cheeks seems to have sunk. I know nothing but surgery will address the sagging skin -- I don't care. Were the sag less poufy I would still look just as old but I might be able to recover the angular lines of my long narrow face (I was never particularly pretty but I was striking).
+I've fooled around in the kitchen a bit with my blender stick and microwave.
+I bought a huge jar of aminophylline tablets without a prescription from a foreign pharmacy a couple years back and made cream from them but tablets contain excipients and fillers -- it just wasn't the same. The fillers made it more difficult for absorption.
+More recently I made a cream using a ton of theobromine which is similar to caffeine in terms of skin care. I rather like it but again, it is nothing near as good as what the compounding pharmacy mixed up into those one pound jars (its not like there were special extra ingredients in there either -- the other ingredients were mineral oil, glycerin, urea, etc.)
+Any ideas for DIY? Or does anyone here have a very reasonable compounding pharmacy they use that ships out of state?
+I have been sick for the last few years, unable to work. Being old is a great disadvantage now that I am back on the market again and if possible, I would love my face to come across as an interesting wreck rather than just podgy
+If you find something that works for cellulite, you could be rich
+There isn't even a legit cellulite cream made by any company, you're definitely not gonna solve it by mixing things up in your kitchen.
+Positive results have been announced from a phase 2a clinical trial evaluating the safety, pharmacokinetics and efficacy of PP405 for the treatment of androgenetic alopecia in adult patients, Pelage Pharmaceuticals announced in a release.1 The company said it plans to initiate phase 3 studies in 2026 to further evaluate the therapy.
Results from the trial (NCT06393452) showed that PP405 met its primary safety endpoint of percentage of patients with treatment related adverse events and serious treatment related adverse events. The therapy also met its primary secondary pharmacokinetic endpoint of concentration in blood plasma.
“Despite affecting millions, hair loss has seen remarkably little progress in clinical research,” Arash Mostaghimi, MD, MPH, FAAD, vice chair of Clinical Trials and Innovation at Brigham and Women’s Hospital, said in a release.1 “What’s compelling about PP405 is that it brings scientific rigor to a space that’s needed it for decades. A well-tolerated, topically delivered therapy that shows measurable biological activity this early is rare. This could reshape how we think about clinical progress in hair growth.”
PP405 takes a different approach from current hair loss treatments, which mostly focus on secondary causes like hormones. Instead, it targets the primary biological pathway that controls the natural hair growth cycle. By acting on hair follicle stem cells—which remain present even in balding areas—PP405 offers a promising option for people often left out by existing therapies.
The study was a randomized, multicenter, double-blind, vehicle-controlled phase 2a trial that evaluated the safety, pharmacokinetics and efficacy of PP405 for the treatment of androgenetic alopecia in adult patients. The study cohort included 78 patients aged 18 to 55 years. Exclusion criteria for the study included having an additional diagnosis of other forms of alopecia, using other hair loss treatments, or using certain medications or having certain medical conditions.
Patients received either 0.05% PP405 topical gel or placebo comparator topical gel vehicle. Patients applied the therapy or placebo once per day for 4 weeks and were followed for up to 12 weeks. After the randomized portion of the study, patients were eligible to enroll in an open-label extension study for 3 months to assess the long term safety of PP405.
The study found that 31% of men with a higher degree of hair loss who received PP405 had a greater than 20% increase in hair density at 8 weeks, compared to 0% in the placebo group. The study also showed PP405 induced new hair growth where there was previously no hair, suggesting the therapy has the potential for regeneration. Additionally, PP405 was seen to be well tolerated with no systemic absorption detected in blood plasma.
“These early clinical results reinforce the potential of our approach to go beyond slowing the hair loss process and directly drive hair follicle regeneration,” Christina Weng, MD, chief medical officer of Pelage, said in a release.1 “We see this as a milestone that expands the possibilities of regenerative medicine. As we advance into the next stage of clinical development, our focus remains on delivering a science-driven solution that works for everyone.”
References
[This article was originally published by our sister publication, Drug Topics.]